In vitro cytotoxic activity of Cymbopogon citratus L. and Cymbopogon nardus L. essential oils from Togo
The leaf essential oils of Cymbopogon citratus L. and Cymbopogon nardus L. (Poaceae) from Togo were steam-distilled, analyzed for percentage composition and investigated in vitro for their potential cytotoxic activity on human epidermic cell line HaCat. The percentage composition showed that the mai...
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| Format: | Article |
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Bangladesh Pharmacological Society
2008-08-01
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| Series: | Bangladesh Journal of Pharmacology |
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| Online Access: | https://www.banglajol.info/index.php/BJP/article/view/1040 |
| _version_ | 1828851224323031040 |
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| author | Koffi Koba Komla Sanda Catherine Guyon Christine Raynaud Jean-Pierre Chaumont Laurence Nicod |
| author_facet | Koffi Koba Komla Sanda Catherine Guyon Christine Raynaud Jean-Pierre Chaumont Laurence Nicod |
| author_sort | Koffi Koba |
| collection | DOAJ |
| description | The leaf essential oils of Cymbopogon citratus L. and Cymbopogon nardus L. (Poaceae) from Togo were steam-distilled, analyzed for percentage composition and investigated in vitro for their potential cytotoxic activity on human epidermic cell line HaCat. The percentage composition showed that the main constituents of essential oils samples were respectively geranial (45.2%), neral (32.4%) and myrc¨ne (10.2%) for C. citratus essential oil and citronellal (35.5%), geraniol (27.9%) and citronellol (10.7%) for that of C. nardus. The in vitro cytotoxicity bioassays on human epidermic cell line HaCaT revealed that the toxicity of the essential oil from C.citratus (IC50: 150 µL.mL-1) was higher than that of the essential oil from C.nardus (IC50: 450 µL.mL-1). Pure commercial neral, geranial, and citronellal standards showed respectively the following IC50 values: 100, 250 and 300 µL.mL-1). Conversely, pure citronellol standard appeared almost non-toxic (IC50>1000 µL.mL-1), proving the major role played in synergy by neral and geranial in the overall toxicity showed by the citratus oil sample tested in this work. |
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| format | Article |
| id | doaj.art-0bf3666caf3a4b1ab7cf78ffd50f9367 |
| institution | Directory Open Access Journal |
| issn | 1991-0088 |
| language | English |
| last_indexed | 2024-12-12T23:27:32Z |
| publishDate | 2008-08-01 |
| publisher | Bangladesh Pharmacological Society |
| record_format | Article |
| series | Bangladesh Journal of Pharmacology |
| spelling | doaj.art-0bf3666caf3a4b1ab7cf78ffd50f93672022-12-22T00:07:57ZengBangladesh Pharmacological SocietyBangladesh Journal of Pharmacology1991-00882008-08-014110.3329/bjp.v4i1.1040In vitro cytotoxic activity of Cymbopogon citratus L. and Cymbopogon nardus L. essential oils from TogoKoffi Koba0Komla Sanda1Catherine Guyon2Christine Raynaud3Jean-Pierre Chaumont4Laurence Nicod5Unité de Recherche sur les Agroressources et la Santé Environnementale, Ecole Supérieure d?Agronomie, Université de Lomé, BP. 20131Unité de Recherche sur les Agroressources et la Santé Environnementale, Ecole Supérieure d?Agronomie, Université de Lomé, BP. 20131Equipe des Sciences Séparatives, Biologiques et Pharmaceutiques, IFR 133, Faculté de Médecine et de Pharmacie, Université de Franche-Comté, Place Saint-Jacques, 25030, BesançonLaboratoire de Chimie Agro-Industrielle, Arômes et Métrologie Sensorielle, UMR 1010, INP-ENSIACET, 118, route de Narbonne, 31077 Toulouse cedexEquipe des Sciences Séparatives, Biologiques et Pharmaceutiques, IFR 133, Faculté de Médecine et de Pharmacie, Université de Franche-Comté, Place Saint-Jacques, 25030, BesançonEquipe des Sciences Séparatives, Biologiques et Pharmaceutiques, IFR 133, Faculté de Médecine et de Pharmacie, Université de Franche-Comté, Place Saint-Jacques, 25030, BesançonThe leaf essential oils of Cymbopogon citratus L. and Cymbopogon nardus L. (Poaceae) from Togo were steam-distilled, analyzed for percentage composition and investigated in vitro for their potential cytotoxic activity on human epidermic cell line HaCat. The percentage composition showed that the main constituents of essential oils samples were respectively geranial (45.2%), neral (32.4%) and myrc¨ne (10.2%) for C. citratus essential oil and citronellal (35.5%), geraniol (27.9%) and citronellol (10.7%) for that of C. nardus. The in vitro cytotoxicity bioassays on human epidermic cell line HaCaT revealed that the toxicity of the essential oil from C.citratus (IC50: 150 µL.mL-1) was higher than that of the essential oil from C.nardus (IC50: 450 µL.mL-1). Pure commercial neral, geranial, and citronellal standards showed respectively the following IC50 values: 100, 250 and 300 µL.mL-1). Conversely, pure citronellol standard appeared almost non-toxic (IC50>1000 µL.mL-1), proving the major role played in synergy by neral and geranial in the overall toxicity showed by the citratus oil sample tested in this work.https://www.banglajol.info/index.php/BJP/article/view/1040Cymbopogon citratusCymbopogon nardusCytotoxicityEssential oilHaCaT cell line |
| spellingShingle | Koffi Koba Komla Sanda Catherine Guyon Christine Raynaud Jean-Pierre Chaumont Laurence Nicod In vitro cytotoxic activity of Cymbopogon citratus L. and Cymbopogon nardus L. essential oils from Togo Bangladesh Journal of Pharmacology Cymbopogon citratus Cymbopogon nardus Cytotoxicity Essential oil HaCaT cell line |
| title | In vitro cytotoxic activity of Cymbopogon citratus L. and Cymbopogon nardus L. essential oils from Togo |
| title_full | In vitro cytotoxic activity of Cymbopogon citratus L. and Cymbopogon nardus L. essential oils from Togo |
| title_fullStr | In vitro cytotoxic activity of Cymbopogon citratus L. and Cymbopogon nardus L. essential oils from Togo |
| title_full_unstemmed | In vitro cytotoxic activity of Cymbopogon citratus L. and Cymbopogon nardus L. essential oils from Togo |
| title_short | In vitro cytotoxic activity of Cymbopogon citratus L. and Cymbopogon nardus L. essential oils from Togo |
| title_sort | in vitro cytotoxic activity of cymbopogon citratus l and cymbopogon nardus l essential oils from togo |
| topic | Cymbopogon citratus Cymbopogon nardus Cytotoxicity Essential oil HaCaT cell line |
| url | https://www.banglajol.info/index.php/BJP/article/view/1040 |
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