Embryonic Stem Cell-Derived Neurons as a Model System for Epigenome Maturation during Development

Embryonic Stem Cell-Derived Neurons as a Model System for Epigenome Maturation during Development

DNA methylation in neurons is directly linked to neuronal genome regulation and maturation. Unlike other tissues, vertebrate neurons accumulate high levels of atypical DNA methylation in the CH sequence context (mCH) during early postnatal brain development. Here, we investigate to what extent neuro...

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Bibliographic Details
Main Authors: Sally Martin, Daniel Poppe, Nelly Olova, Conor O’Leary, Elena Ivanova, Jahnvi Pflueger, Jennifer Dechka, Rebecca K. Simmons, Helen M. Cooper, Wolf Reik, Ryan Lister, Ernst J. Wolvetang
Format: Article
Language:English
Published: MDPI AG 2023-04-01
Series:Genes
Subjects:
epigenomics
neuroscience
DNA methylation
neuronal maturation
cell culture systems
Online Access:https://www.mdpi.com/2073-4425/14/5/957

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