AMH in Males: Effects of Body Size and Composition on Serum AMH Levels
Serum concentrations of anti-Müllerian hormone (AMH) have been found to decrease with increasing body mass index (BMI) in many studies. It is not yet clear whether this stems from an adverse effect of adiposity on AMH production, or from dilution due to the greater blood volume that accompanies a la...
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MDPI AG
2023-07-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/12/13/4478 |
| _version_ | 1797591393235894272 |
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| author | Veronika Tandl Christoph Haudum Katharina Eberhard Barbara Hutz Ines Foessl Ewald Kolesnik Andreas Zirlik Dirk von Lewinski Daniel Scherr Nicolas Verheyen Thomas Pieber Barbara Obermayer-Pietsch |
| author_facet | Veronika Tandl Christoph Haudum Katharina Eberhard Barbara Hutz Ines Foessl Ewald Kolesnik Andreas Zirlik Dirk von Lewinski Daniel Scherr Nicolas Verheyen Thomas Pieber Barbara Obermayer-Pietsch |
| author_sort | Veronika Tandl |
| collection | DOAJ |
| description | Serum concentrations of anti-Müllerian hormone (AMH) have been found to decrease with increasing body mass index (BMI) in many studies. It is not yet clear whether this stems from an adverse effect of adiposity on AMH production, or from dilution due to the greater blood volume that accompanies a larger body size. To investigate a possible hemodilution effect, we explored the relationships between serum AMH levels and different parameters of body composition using linear regression models in a cohort of adult males. Body weight, lean mass (LM), and body surface area (BSA) were found to be better predictors of AMH than measures of adiposity, such as BMI or fat mass. Since both LM and BSA correlate with plasma volume better than adipose tissue, we conclude that hemodilution of AMH does occur in adult males and should be considered for normalization in future studies. |
| first_indexed | 2024-03-11T01:36:45Z |
| format | Article |
| id | doaj.art-0bf85d992b9a4c90a2559bc1e900f7bb |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-11T01:36:45Z |
| publishDate | 2023-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-0bf85d992b9a4c90a2559bc1e900f7bb2023-11-18T16:54:27ZengMDPI AGJournal of Clinical Medicine2077-03832023-07-011213447810.3390/jcm12134478AMH in Males: Effects of Body Size and Composition on Serum AMH LevelsVeronika Tandl0Christoph Haudum1Katharina Eberhard2Barbara Hutz3Ines Foessl4Ewald Kolesnik5Andreas Zirlik6Dirk von Lewinski7Daniel Scherr8Nicolas Verheyen9Thomas Pieber10Barbara Obermayer-Pietsch11Division of Endocrinology and Diabetology, Department of Internal Medicine, Medical University of Graz, 8036 Graz, AustriaDivision of Endocrinology and Diabetology, Department of Internal Medicine, Medical University of Graz, 8036 Graz, AustriaCore Facility Computational Bioanalytics, Medical University Graz, 8036 Graz, AustriaDivision of Endocrinology and Diabetology, Department of Internal Medicine, Medical University of Graz, 8036 Graz, AustriaDivision of Endocrinology and Diabetology, Department of Internal Medicine, Medical University of Graz, 8036 Graz, AustriaDivision of Cardiology, Department of Internal Medicine and University Heart Center Graz, Medical University of Graz, 8036 Graz, AustriaDivision of Cardiology, Department of Internal Medicine and University Heart Center Graz, Medical University of Graz, 8036 Graz, AustriaDivision of Cardiology, Department of Internal Medicine and University Heart Center Graz, Medical University of Graz, 8036 Graz, AustriaDivision of Cardiology, Department of Internal Medicine and University Heart Center Graz, Medical University of Graz, 8036 Graz, AustriaDivision of Cardiology, Department of Internal Medicine and University Heart Center Graz, Medical University of Graz, 8036 Graz, AustriaDivision of Endocrinology and Diabetology, Department of Internal Medicine, Medical University of Graz, 8036 Graz, AustriaDivision of Endocrinology and Diabetology, Department of Internal Medicine, Medical University of Graz, 8036 Graz, AustriaSerum concentrations of anti-Müllerian hormone (AMH) have been found to decrease with increasing body mass index (BMI) in many studies. It is not yet clear whether this stems from an adverse effect of adiposity on AMH production, or from dilution due to the greater blood volume that accompanies a larger body size. To investigate a possible hemodilution effect, we explored the relationships between serum AMH levels and different parameters of body composition using linear regression models in a cohort of adult males. Body weight, lean mass (LM), and body surface area (BSA) were found to be better predictors of AMH than measures of adiposity, such as BMI or fat mass. Since both LM and BSA correlate with plasma volume better than adipose tissue, we conclude that hemodilution of AMH does occur in adult males and should be considered for normalization in future studies.https://www.mdpi.com/2077-0383/12/13/4478anti-Müllerian hormonehemodilutionbody mass indexbody composition |
| spellingShingle | Veronika Tandl Christoph Haudum Katharina Eberhard Barbara Hutz Ines Foessl Ewald Kolesnik Andreas Zirlik Dirk von Lewinski Daniel Scherr Nicolas Verheyen Thomas Pieber Barbara Obermayer-Pietsch AMH in Males: Effects of Body Size and Composition on Serum AMH Levels Journal of Clinical Medicine anti-Müllerian hormone hemodilution body mass index body composition |
| title | AMH in Males: Effects of Body Size and Composition on Serum AMH Levels |
| title_full | AMH in Males: Effects of Body Size and Composition on Serum AMH Levels |
| title_fullStr | AMH in Males: Effects of Body Size and Composition on Serum AMH Levels |
| title_full_unstemmed | AMH in Males: Effects of Body Size and Composition on Serum AMH Levels |
| title_short | AMH in Males: Effects of Body Size and Composition on Serum AMH Levels |
| title_sort | amh in males effects of body size and composition on serum amh levels |
| topic | anti-Müllerian hormone hemodilution body mass index body composition |
| url | https://www.mdpi.com/2077-0383/12/13/4478 |
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