The S100A4 Transcriptional Inhibitor Niclosamide Reduces Pro-Inflammatory and Migratory Phenotypes of Microglia: Implications for Amyotrophic Lateral Sclerosis

The S100A4 Transcriptional Inhibitor Niclosamide Reduces Pro-Inflammatory and Migratory Phenotypes of Microglia: Implications for Amyotrophic Lateral Sclerosis

S100A4, belonging to a large multifunctional S100 protein family, is a Ca<sup>2+</sup>-binding protein with a significant role in stimulating the motility of cancer and immune cells, as well as in promoting pro-inflammatory properties in different cell types. In the CNS, there is limited...

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Bibliographic Details
Main Authors: Alessia Serrano, Savina Apolloni, Simona Rossi, Serena Lattante, Mario Sabatelli, Mina Peric, Pavle Andjus, Fabrizio Michetti, Maria Teresa Carrì, Mauro Cozzolino, Nadia D’Ambrosi
Format: Article
Language:English
Published: MDPI AG 2019-10-01
Series:Cells
Subjects:
als
astrocytes
fibroblasts
microglia
mtor
neurodegeneration
neuroinflammation
nf-κb
niclosamide
s100a4
Online Access:https://www.mdpi.com/2073-4409/8/10/1261

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