The S100A4 Transcriptional Inhibitor Niclosamide Reduces Pro-Inflammatory and Migratory Phenotypes of Microglia: Implications for Amyotrophic Lateral Sclerosis
S100A4, belonging to a large multifunctional S100 protein family, is a Ca<sup>2+</sup>-binding protein with a significant role in stimulating the motility of cancer and immune cells, as well as in promoting pro-inflammatory properties in different cell types. In the CNS, there is limited...
Main Authors: | Alessia Serrano, Savina Apolloni, Simona Rossi, Serena Lattante, Mario Sabatelli, Mina Peric, Pavle Andjus, Fabrizio Michetti, Maria Teresa Carrì, Mauro Cozzolino, Nadia D’Ambrosi |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2019-10-01
|
Series: | Cells |
Subjects: | |
Online Access: | https://www.mdpi.com/2073-4409/8/10/1261 |
Similar Items
-
Neuroinflammation in Friedreich’s Ataxia
by: Savina Apolloni, et al.
Published: (2022-06-01) -
S100A4 in the Physiology and Pathology of the Central and Peripheral Nervous System
by: Nadia D’Ambrosi, et al.
Published: (2021-04-01) -
Niclosamide alleviates pathological angiogenesis in hepatopulmonary syndrome by inhibiting
by: LI Caiyi, et al.
Published: (2023-06-01) -
Repurposing niclosamide for the treatment of neurological disorders
by: Savina Apolloni, et al.
Published: (2023-01-01) -
Sublethal effects of niclosamide on the aquatic snail Pomacea canaliculata
by: Chunping Yang, et al.
Published: (2023-07-01)