The Regulatory Role of MicroRNAs in Obesity and Obesity-Derived Ailments
Obesity is a condition that is characterized by the presence of excessive adipose tissue in the body. Obesity has become one of the main health concerns worldwide since it can lead to other chronic ailments, such as type 2 diabetes or fatty liver disease, and it could be an aggravating factor in inf...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-11-01
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| Series: | Genes |
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| Online Access: | https://www.mdpi.com/2073-4425/14/11/2070 |
| _version_ | 1797459168286736384 |
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| author | Javier A. Benavides-Aguilar Andrea Torres-Copado José Isidoro-Sánchez Surajit Pathak Asim K. Duttaroy Antara Banerjee Sujay Paul |
| author_facet | Javier A. Benavides-Aguilar Andrea Torres-Copado José Isidoro-Sánchez Surajit Pathak Asim K. Duttaroy Antara Banerjee Sujay Paul |
| author_sort | Javier A. Benavides-Aguilar |
| collection | DOAJ |
| description | Obesity is a condition that is characterized by the presence of excessive adipose tissue in the body. Obesity has become one of the main health concerns worldwide since it can lead to other chronic ailments, such as type 2 diabetes or fatty liver disease, and it could be an aggravating factor in infections. MicroRNAs (miRNAs) are small, non-coding RNA molecules that regulate gene expression and can play an important role in controlling crucial biological processes involved in the onset of obesity, such as lipogenesis, adipogenesis, lipid metabolism, or the regulation of cytokines and chemokines. Moreover, chemical compounds present in food or food packaging can alter miRNA expression and regulate the aforementioned biological mechanisms related to diabetes onset and progression. Furthermore, therapies, such as bariatric surgery and aerobic exercise training, can also influence the expression profile of miRNAs in obesity. Therefore, the present review provides insight into the current research on the role of miRNAs in obesity and obesity-derived ailments, intending to develop novel therapies to effectively manage these disorders. |
| first_indexed | 2024-03-09T16:47:33Z |
| format | Article |
| id | doaj.art-0bf903ef0c8d4028bd0a6db300ee94a6 |
| institution | Directory Open Access Journal |
| issn | 2073-4425 |
| language | English |
| last_indexed | 2024-03-09T16:47:33Z |
| publishDate | 2023-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Genes |
| spelling | doaj.art-0bf903ef0c8d4028bd0a6db300ee94a62023-11-24T14:44:04ZengMDPI AGGenes2073-44252023-11-011411207010.3390/genes14112070The Regulatory Role of MicroRNAs in Obesity and Obesity-Derived AilmentsJavier A. Benavides-Aguilar0Andrea Torres-Copado1José Isidoro-Sánchez2Surajit Pathak3Asim K. Duttaroy4Antara Banerjee5Sujay Paul6Technical University of Denmark, 2800 Kongens Lyngby, DenmarkNatProLab-Plant Innovation Lab, School of Engineering and Sciences, Tecnologico de Monterrey, Queretaro 76130, MexicoNatProLab-Plant Innovation Lab, School of Engineering and Sciences, Tecnologico de Monterrey, Queretaro 76130, MexicoChettinad Academy of Research and Education (CARE), Chettinad Hospital and Research Institute (CHRI), Department of Medical Biotechnology, Faculty of Allied Health Sciences, Chennai 603103, IndiaDepartment of Nutrition, Institute of Basic Medical Sciences, Faculty of Medicine, University of Oslo, P.O. Box 1046, N-0316 Oslo, NorwayChettinad Academy of Research and Education (CARE), Chettinad Hospital and Research Institute (CHRI), Department of Medical Biotechnology, Faculty of Allied Health Sciences, Chennai 603103, IndiaNatProLab-Plant Innovation Lab, School of Engineering and Sciences, Tecnologico de Monterrey, Queretaro 76130, MexicoObesity is a condition that is characterized by the presence of excessive adipose tissue in the body. Obesity has become one of the main health concerns worldwide since it can lead to other chronic ailments, such as type 2 diabetes or fatty liver disease, and it could be an aggravating factor in infections. MicroRNAs (miRNAs) are small, non-coding RNA molecules that regulate gene expression and can play an important role in controlling crucial biological processes involved in the onset of obesity, such as lipogenesis, adipogenesis, lipid metabolism, or the regulation of cytokines and chemokines. Moreover, chemical compounds present in food or food packaging can alter miRNA expression and regulate the aforementioned biological mechanisms related to diabetes onset and progression. Furthermore, therapies, such as bariatric surgery and aerobic exercise training, can also influence the expression profile of miRNAs in obesity. Therefore, the present review provides insight into the current research on the role of miRNAs in obesity and obesity-derived ailments, intending to develop novel therapies to effectively manage these disorders.https://www.mdpi.com/2073-4425/14/11/2070miRNAobesityadipogenesislipogenesisadipose tissue |
| spellingShingle | Javier A. Benavides-Aguilar Andrea Torres-Copado José Isidoro-Sánchez Surajit Pathak Asim K. Duttaroy Antara Banerjee Sujay Paul The Regulatory Role of MicroRNAs in Obesity and Obesity-Derived Ailments Genes miRNA obesity adipogenesis lipogenesis adipose tissue |
| title | The Regulatory Role of MicroRNAs in Obesity and Obesity-Derived Ailments |
| title_full | The Regulatory Role of MicroRNAs in Obesity and Obesity-Derived Ailments |
| title_fullStr | The Regulatory Role of MicroRNAs in Obesity and Obesity-Derived Ailments |
| title_full_unstemmed | The Regulatory Role of MicroRNAs in Obesity and Obesity-Derived Ailments |
| title_short | The Regulatory Role of MicroRNAs in Obesity and Obesity-Derived Ailments |
| title_sort | regulatory role of micrornas in obesity and obesity derived ailments |
| topic | miRNA obesity adipogenesis lipogenesis adipose tissue |
| url | https://www.mdpi.com/2073-4425/14/11/2070 |
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