The Beneficial Effects of Hydrogen-Rich Saline Irrigation on Chronic Rhinitis: A Randomized, Double-Blind Clinical Trial
Ling Jin,1,* Kai Fan,1,* Shiwang Tan,1 Shangxi Liu,1 Qin Ge,1 Yang Wang,1 Zisheng Ai,2 Shaoqing Yu1 1Department of Otolaryngology, Tongji Hospital, School of Medicine, Tongji University, Shanghai, 200065, People’s Republic of China; 2Department of Medical Statistics, School of Medicine, To...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Dove Medical Press
2022-07-01
|
| Series: | Journal of Inflammation Research |
| Subjects: | |
| Online Access: | https://www.dovepress.com/the-beneficial-effects-of-hydrogen-rich-saline-irrigation-on-chronic-r-peer-reviewed-fulltext-article-JIR |
| _version_ | 1828515507281592320 |
|---|---|
| author | Jin L Fan K Tan S Liu S Ge Q Wang Y Ai Z Yu S |
| author_facet | Jin L Fan K Tan S Liu S Ge Q Wang Y Ai Z Yu S |
| author_sort | Jin L |
| collection | DOAJ |
| description | Ling Jin,1,* Kai Fan,1,* Shiwang Tan,1 Shangxi Liu,1 Qin Ge,1 Yang Wang,1 Zisheng Ai,2 Shaoqing Yu1 1Department of Otolaryngology, Tongji Hospital, School of Medicine, Tongji University, Shanghai, 200065, People’s Republic of China; 2Department of Medical Statistics, School of Medicine, Tongji University, Shanghai, 200331, People’s Republic of China*These authors contributed equally to this workCorrespondence: Shaoqing Yu, Department of Otolaryngology, Tongji Hospital, 389 Xincun Road, Putuo District, Shanghai, 200065, People’s Republic of China, Tel/Fax +862166111042, Email yu_shaoqing@163.com Zisheng Ai, Department of Medical Statistics, School of Medicine, No. 500 Zhennan Road, Shanghai, 200331, People’s Republic of China, Email azs1966@126.comPurpose: Chronic rhinitis (CR) is a common chronic inflammation of the nasal mucosa. Nasal saline irrigation has been demonstrated to be an effective treatment for CR. In this study, we investigated the beneficial effects of hydrogen-rich saline irrigation as an anti-inflammatory irrigation therapy for CR and compared its effectiveness over saline irrigation. Hydrogen-rich saline (HRS) was investigated due to its antioxidant and anti-inflammatory properties.Methods: A total of 120 patients with CR were randomly divided into two groups, patients irrigated with HR (HRS group) and the control group irrigated with saline (NS group). A randomized, double-blind control study was performed. The main observation index in this study was the total score of nasal symptoms (TNSS). In addition, eosinophilic protein (ECP) of the nasal secretions, nasal nitric oxide (nNO) levels, and levels of regulatory T cells (Treg) and regulatory B cells (Breg) were also compared between the two groups. Furthermore, patients with allergic rhinitis (AR) and non-allergic rhinitis (NAR) were also evaluated based on serum-specific IgE positivity.Results: After treatment, TNSS and nasal ECP in the two groups decreased significantly (P< 0.05), with patients in the HRS group showing significantly lower levels compared to the NS group (P< 0.05). There were no significant differences in Treg and Breg levels between the two groups. Subgroup analysis showed that TNSS in the AR-HRS group showed a more significant reduction compared to the AR-NS group (P< 0.05); however, there were no significant differences for the other inflammatory biomarkers (P> 0.05). ECP levels were reduced significantly in the NAR subgroup compared to NS irrigation (P< 0.05). There were no obvious adverse events observed in patients during the entire treatment period.Conclusion: Compared to saline irrigation, HRS nasal irrigation was found to improve CR clinical symptoms, especially in patients with AR. HRS could effectively be used for the clinical treatment of patients with CR.Keywords: chronic rhinitis, allergic rhinitis, non-allergic rhinitis, hydrogen-rich, nasal irrigation |
| first_indexed | 2024-12-11T18:14:07Z |
| format | Article |
| id | doaj.art-0bf969a6c4044d85bf79080fe9653b26 |
| institution | Directory Open Access Journal |
| issn | 1178-7031 |
| language | English |
| last_indexed | 2024-12-11T18:14:07Z |
| publishDate | 2022-07-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Journal of Inflammation Research |
| spelling | doaj.art-0bf969a6c4044d85bf79080fe9653b262022-12-22T00:55:28ZengDove Medical PressJournal of Inflammation Research1178-70312022-07-01Volume 153983399576600The Beneficial Effects of Hydrogen-Rich Saline Irrigation on Chronic Rhinitis: A Randomized, Double-Blind Clinical TrialJin LFan KTan SLiu SGe QWang YAi ZYu SLing Jin,1,* Kai Fan,1,* Shiwang Tan,1 Shangxi Liu,1 Qin Ge,1 Yang Wang,1 Zisheng Ai,2 Shaoqing Yu1 1Department of Otolaryngology, Tongji Hospital, School of Medicine, Tongji University, Shanghai, 200065, People’s Republic of China; 2Department of Medical Statistics, School of Medicine, Tongji University, Shanghai, 200331, People’s Republic of China*These authors contributed equally to this workCorrespondence: Shaoqing Yu, Department of Otolaryngology, Tongji Hospital, 389 Xincun Road, Putuo District, Shanghai, 200065, People’s Republic of China, Tel/Fax +862166111042, Email yu_shaoqing@163.com Zisheng Ai, Department of Medical Statistics, School of Medicine, No. 500 Zhennan Road, Shanghai, 200331, People’s Republic of China, Email azs1966@126.comPurpose: Chronic rhinitis (CR) is a common chronic inflammation of the nasal mucosa. Nasal saline irrigation has been demonstrated to be an effective treatment for CR. In this study, we investigated the beneficial effects of hydrogen-rich saline irrigation as an anti-inflammatory irrigation therapy for CR and compared its effectiveness over saline irrigation. Hydrogen-rich saline (HRS) was investigated due to its antioxidant and anti-inflammatory properties.Methods: A total of 120 patients with CR were randomly divided into two groups, patients irrigated with HR (HRS group) and the control group irrigated with saline (NS group). A randomized, double-blind control study was performed. The main observation index in this study was the total score of nasal symptoms (TNSS). In addition, eosinophilic protein (ECP) of the nasal secretions, nasal nitric oxide (nNO) levels, and levels of regulatory T cells (Treg) and regulatory B cells (Breg) were also compared between the two groups. Furthermore, patients with allergic rhinitis (AR) and non-allergic rhinitis (NAR) were also evaluated based on serum-specific IgE positivity.Results: After treatment, TNSS and nasal ECP in the two groups decreased significantly (P< 0.05), with patients in the HRS group showing significantly lower levels compared to the NS group (P< 0.05). There were no significant differences in Treg and Breg levels between the two groups. Subgroup analysis showed that TNSS in the AR-HRS group showed a more significant reduction compared to the AR-NS group (P< 0.05); however, there were no significant differences for the other inflammatory biomarkers (P> 0.05). ECP levels were reduced significantly in the NAR subgroup compared to NS irrigation (P< 0.05). There were no obvious adverse events observed in patients during the entire treatment period.Conclusion: Compared to saline irrigation, HRS nasal irrigation was found to improve CR clinical symptoms, especially in patients with AR. HRS could effectively be used for the clinical treatment of patients with CR.Keywords: chronic rhinitis, allergic rhinitis, non-allergic rhinitis, hydrogen-rich, nasal irrigationhttps://www.dovepress.com/the-beneficial-effects-of-hydrogen-rich-saline-irrigation-on-chronic-r-peer-reviewed-fulltext-article-JIRchronic rhinitisallergic rhinitisnon-allergic rhinitishydrogen-richnasal irrigation |
| spellingShingle | Jin L Fan K Tan S Liu S Ge Q Wang Y Ai Z Yu S The Beneficial Effects of Hydrogen-Rich Saline Irrigation on Chronic Rhinitis: A Randomized, Double-Blind Clinical Trial Journal of Inflammation Research chronic rhinitis allergic rhinitis non-allergic rhinitis hydrogen-rich nasal irrigation |
| title | The Beneficial Effects of Hydrogen-Rich Saline Irrigation on Chronic Rhinitis: A Randomized, Double-Blind Clinical Trial |
| title_full | The Beneficial Effects of Hydrogen-Rich Saline Irrigation on Chronic Rhinitis: A Randomized, Double-Blind Clinical Trial |
| title_fullStr | The Beneficial Effects of Hydrogen-Rich Saline Irrigation on Chronic Rhinitis: A Randomized, Double-Blind Clinical Trial |
| title_full_unstemmed | The Beneficial Effects of Hydrogen-Rich Saline Irrigation on Chronic Rhinitis: A Randomized, Double-Blind Clinical Trial |
| title_short | The Beneficial Effects of Hydrogen-Rich Saline Irrigation on Chronic Rhinitis: A Randomized, Double-Blind Clinical Trial |
| title_sort | beneficial effects of hydrogen rich saline irrigation on chronic rhinitis a randomized double blind clinical trial |
| topic | chronic rhinitis allergic rhinitis non-allergic rhinitis hydrogen-rich nasal irrigation |
| url | https://www.dovepress.com/the-beneficial-effects-of-hydrogen-rich-saline-irrigation-on-chronic-r-peer-reviewed-fulltext-article-JIR |
| work_keys_str_mv | AT jinl thebeneficialeffectsofhydrogenrichsalineirrigationonchronicrhinitisarandomizeddoubleblindclinicaltrial AT fank thebeneficialeffectsofhydrogenrichsalineirrigationonchronicrhinitisarandomizeddoubleblindclinicaltrial AT tans thebeneficialeffectsofhydrogenrichsalineirrigationonchronicrhinitisarandomizeddoubleblindclinicaltrial AT lius thebeneficialeffectsofhydrogenrichsalineirrigationonchronicrhinitisarandomizeddoubleblindclinicaltrial AT geq thebeneficialeffectsofhydrogenrichsalineirrigationonchronicrhinitisarandomizeddoubleblindclinicaltrial AT wangy thebeneficialeffectsofhydrogenrichsalineirrigationonchronicrhinitisarandomizeddoubleblindclinicaltrial AT aiz thebeneficialeffectsofhydrogenrichsalineirrigationonchronicrhinitisarandomizeddoubleblindclinicaltrial AT yus thebeneficialeffectsofhydrogenrichsalineirrigationonchronicrhinitisarandomizeddoubleblindclinicaltrial AT jinl beneficialeffectsofhydrogenrichsalineirrigationonchronicrhinitisarandomizeddoubleblindclinicaltrial AT fank beneficialeffectsofhydrogenrichsalineirrigationonchronicrhinitisarandomizeddoubleblindclinicaltrial AT tans beneficialeffectsofhydrogenrichsalineirrigationonchronicrhinitisarandomizeddoubleblindclinicaltrial AT lius beneficialeffectsofhydrogenrichsalineirrigationonchronicrhinitisarandomizeddoubleblindclinicaltrial AT geq beneficialeffectsofhydrogenrichsalineirrigationonchronicrhinitisarandomizeddoubleblindclinicaltrial AT wangy beneficialeffectsofhydrogenrichsalineirrigationonchronicrhinitisarandomizeddoubleblindclinicaltrial AT aiz beneficialeffectsofhydrogenrichsalineirrigationonchronicrhinitisarandomizeddoubleblindclinicaltrial AT yus beneficialeffectsofhydrogenrichsalineirrigationonchronicrhinitisarandomizeddoubleblindclinicaltrial |