Causes of necrotic features in fine-needle aspirates from cervical lymph nodes
Background Lymph node fine-needle aspiration (LN FNA) cytology indicates necrosis in various diseases. Dominant necrotic features make the diagnosis of underlying conditions very difficult. Methods We retrospectively reviewed 460 patients who underwent cervical LN aspiration cytology that revealed n...
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| Format: | Article |
| Language: | English |
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Korean Society of Pathologists & the Korean Society for Cytopathology
2021-01-01
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| Series: | Journal of Pathology and Translational Medicine |
| Subjects: | |
| Online Access: | http://www.jpatholtm.org/upload/pdf/jptm-2020-09-28.pdf |
| _version_ | 1819297364707377152 |
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| author | Young Jin Seo Hyeongchan Shin Hye Won Lee Hye Ra Jung |
| author_facet | Young Jin Seo Hyeongchan Shin Hye Won Lee Hye Ra Jung |
| author_sort | Young Jin Seo |
| collection | DOAJ |
| description | Background Lymph node fine-needle aspiration (LN FNA) cytology indicates necrosis in various diseases. Dominant necrotic features make the diagnosis of underlying conditions very difficult. Methods We retrospectively reviewed 460 patients who underwent cervical LN aspiration cytology that revealed necrotic findings at Keimyung University Dongsan Hospital in Daegu, Korea, from 2003–2017. Each specimen was evaluated and analyzed in association with the clinical findings, biopsy findings, and/or other ancillary tests, including acid-fast bacilli staining and molecular testing for Mycobacterium tuberculosis. Results When necrotic features were noted upon cervical LN FNA cytology, the most common pathologic LN FNA category was necrosis alone (31.5%). The second most common category was granulomatous inflammation (31.3%), followed by Kikuchi disease (20.0%) and malignant neoplasm (8.7%). In cases where the cervical LN FNA revealed necrosis alone, the most common final diagnosis was tuberculosis. In young patients, Kikuchi disease should be considered as one cervical LN FNA category, while metastatic carcinoma should be suspected in older patients. Conclusions Even when necrosis alone is observed in LN FNA cytology, it is important to determine the cause through further evaluation. |
| first_indexed | 2024-12-24T05:12:50Z |
| format | Article |
| id | doaj.art-0bfa8a8843a34796a70757cdc114c66e |
| institution | Directory Open Access Journal |
| issn | 2383-7837 2383-7845 |
| language | English |
| last_indexed | 2024-12-24T05:12:50Z |
| publishDate | 2021-01-01 |
| publisher | Korean Society of Pathologists & the Korean Society for Cytopathology |
| record_format | Article |
| series | Journal of Pathology and Translational Medicine |
| spelling | doaj.art-0bfa8a8843a34796a70757cdc114c66e2022-12-21T17:13:38ZengKorean Society of Pathologists & the Korean Society for CytopathologyJournal of Pathology and Translational Medicine2383-78372383-78452021-01-01551606710.4132/jptm.2020.09.2816941Causes of necrotic features in fine-needle aspirates from cervical lymph nodesYoung Jin Seo0Hyeongchan Shin1Hye Won Lee2Hye Ra Jung3 Department of Pathology, Keimyung University Dongsan Hospital, Daegu, Korea Department of Pathology, Keimyung University Dongsan Hospital, Daegu, Korea Department of Pathology, Keimyung University Dongsan Hospital, Daegu, Korea Department of Pathology, Keimyung University Dongsan Hospital, Daegu, KoreaBackground Lymph node fine-needle aspiration (LN FNA) cytology indicates necrosis in various diseases. Dominant necrotic features make the diagnosis of underlying conditions very difficult. Methods We retrospectively reviewed 460 patients who underwent cervical LN aspiration cytology that revealed necrotic findings at Keimyung University Dongsan Hospital in Daegu, Korea, from 2003–2017. Each specimen was evaluated and analyzed in association with the clinical findings, biopsy findings, and/or other ancillary tests, including acid-fast bacilli staining and molecular testing for Mycobacterium tuberculosis. Results When necrotic features were noted upon cervical LN FNA cytology, the most common pathologic LN FNA category was necrosis alone (31.5%). The second most common category was granulomatous inflammation (31.3%), followed by Kikuchi disease (20.0%) and malignant neoplasm (8.7%). In cases where the cervical LN FNA revealed necrosis alone, the most common final diagnosis was tuberculosis. In young patients, Kikuchi disease should be considered as one cervical LN FNA category, while metastatic carcinoma should be suspected in older patients. Conclusions Even when necrosis alone is observed in LN FNA cytology, it is important to determine the cause through further evaluation.http://www.jpatholtm.org/upload/pdf/jptm-2020-09-28.pdffine-needle aspirationlymph nodenecrosistuberculosiskikuchi disease |
| spellingShingle | Young Jin Seo Hyeongchan Shin Hye Won Lee Hye Ra Jung Causes of necrotic features in fine-needle aspirates from cervical lymph nodes Journal of Pathology and Translational Medicine fine-needle aspiration lymph node necrosis tuberculosis kikuchi disease |
| title | Causes of necrotic features in fine-needle aspirates from cervical lymph nodes |
| title_full | Causes of necrotic features in fine-needle aspirates from cervical lymph nodes |
| title_fullStr | Causes of necrotic features in fine-needle aspirates from cervical lymph nodes |
| title_full_unstemmed | Causes of necrotic features in fine-needle aspirates from cervical lymph nodes |
| title_short | Causes of necrotic features in fine-needle aspirates from cervical lymph nodes |
| title_sort | causes of necrotic features in fine needle aspirates from cervical lymph nodes |
| topic | fine-needle aspiration lymph node necrosis tuberculosis kikuchi disease |
| url | http://www.jpatholtm.org/upload/pdf/jptm-2020-09-28.pdf |
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