Cardiac and vascular changes in elderly atherosclerotic mice: the influence of gender
<p>Abstract</p> <p>Background</p> <p>Although advanced age is considered a risk factor for several diseases, the impact of gender on age-associated cardiovascular diseases, such as atherosclerotic processes and valvular diseases, remains not completely clarified. The pr...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2010-08-01
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| Series: | Lipids in Health and Disease |
| Online Access: | http://www.lipidworld.com/content/9/1/87 |
| _version_ | 1818492196903452672 |
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| author | Pereira Thiago MC Nogueira Breno V Lima Leandro CF Porto Marcella L Arruda Jose A Vasquez Elisardo C Meyrelles Silvana S |
| author_facet | Pereira Thiago MC Nogueira Breno V Lima Leandro CF Porto Marcella L Arruda Jose A Vasquez Elisardo C Meyrelles Silvana S |
| author_sort | Pereira Thiago MC |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Although advanced age is considered a risk factor for several diseases, the impact of gender on age-associated cardiovascular diseases, such as atherosclerotic processes and valvular diseases, remains not completely clarified. The present study was designed to assess aortic valve morphology and function and vascular damage in elderly using the apolipoprotein E knockout (ApoE KO) mouse. Our hypothesis was that advanced age-related cardiovascular changes are aggravated in atherosclerotic male mice.</p> <p>Methods</p> <p>The grade (0 to 4) of aortic regurgitation was evaluated through angiography. In addition, vascular lipid deposition and senescence were evaluated through histochemical analyses in aged male and female ApoE KO mice, and the results were compared to wild-type C57BL/6J (C57) mice.</p> <p>Results</p> <p>Aortic regurgitation was observed in 92% of the male ApoE KO mice and 100% of the male C57 mice. Comparatively, in age-matched female ApoE KO and C57 mice, aortic regurgitation was observed in a proportion of 58% and 53%, respectively. Histological analysis of the aorta showed an outward (positive) remodeling in ApoE KO mice (female: 1.86 ± 0.15; male: 1.89 ± 0.68) using C57 groups as reference values. Histochemical evaluation of the aorta showed lipid deposition and vascular senescence only in the ApoE KO group, which were more pronounced in male mice.</p> <p>Conclusion</p> <p>The data show that male gender contributes to the progression of aortic regurgitation and that hypercholesterolemia and male gender additively contribute to the occurrence of lipid deposition and vascular senescence in elderly mice.</p> |
| first_indexed | 2024-12-10T17:40:02Z |
| format | Article |
| id | doaj.art-0bfde4a32389405f8e39ff2ff98a0309 |
| institution | Directory Open Access Journal |
| issn | 1476-511X |
| language | English |
| last_indexed | 2024-12-10T17:40:02Z |
| publishDate | 2010-08-01 |
| publisher | BMC |
| record_format | Article |
| series | Lipids in Health and Disease |
| spelling | doaj.art-0bfde4a32389405f8e39ff2ff98a03092022-12-22T01:39:23ZengBMCLipids in Health and Disease1476-511X2010-08-01918710.1186/1476-511X-9-87Cardiac and vascular changes in elderly atherosclerotic mice: the influence of genderPereira Thiago MCNogueira Breno VLima Leandro CFPorto Marcella LArruda Jose AVasquez Elisardo CMeyrelles Silvana S<p>Abstract</p> <p>Background</p> <p>Although advanced age is considered a risk factor for several diseases, the impact of gender on age-associated cardiovascular diseases, such as atherosclerotic processes and valvular diseases, remains not completely clarified. The present study was designed to assess aortic valve morphology and function and vascular damage in elderly using the apolipoprotein E knockout (ApoE KO) mouse. Our hypothesis was that advanced age-related cardiovascular changes are aggravated in atherosclerotic male mice.</p> <p>Methods</p> <p>The grade (0 to 4) of aortic regurgitation was evaluated through angiography. In addition, vascular lipid deposition and senescence were evaluated through histochemical analyses in aged male and female ApoE KO mice, and the results were compared to wild-type C57BL/6J (C57) mice.</p> <p>Results</p> <p>Aortic regurgitation was observed in 92% of the male ApoE KO mice and 100% of the male C57 mice. Comparatively, in age-matched female ApoE KO and C57 mice, aortic regurgitation was observed in a proportion of 58% and 53%, respectively. Histological analysis of the aorta showed an outward (positive) remodeling in ApoE KO mice (female: 1.86 ± 0.15; male: 1.89 ± 0.68) using C57 groups as reference values. Histochemical evaluation of the aorta showed lipid deposition and vascular senescence only in the ApoE KO group, which were more pronounced in male mice.</p> <p>Conclusion</p> <p>The data show that male gender contributes to the progression of aortic regurgitation and that hypercholesterolemia and male gender additively contribute to the occurrence of lipid deposition and vascular senescence in elderly mice.</p>http://www.lipidworld.com/content/9/1/87 |
| spellingShingle | Pereira Thiago MC Nogueira Breno V Lima Leandro CF Porto Marcella L Arruda Jose A Vasquez Elisardo C Meyrelles Silvana S Cardiac and vascular changes in elderly atherosclerotic mice: the influence of gender Lipids in Health and Disease |
| title | Cardiac and vascular changes in elderly atherosclerotic mice: the influence of gender |
| title_full | Cardiac and vascular changes in elderly atherosclerotic mice: the influence of gender |
| title_fullStr | Cardiac and vascular changes in elderly atherosclerotic mice: the influence of gender |
| title_full_unstemmed | Cardiac and vascular changes in elderly atherosclerotic mice: the influence of gender |
| title_short | Cardiac and vascular changes in elderly atherosclerotic mice: the influence of gender |
| title_sort | cardiac and vascular changes in elderly atherosclerotic mice the influence of gender |
| url | http://www.lipidworld.com/content/9/1/87 |
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