Dopamine neuronal loss contributes to memory and reward dysfunction in a model of Alzheimer’s disease
Dopaminergic dysfunction occurs in Alzheimer’s disease (AD). The authors show that in a mouse model of AD, loss of dopaminergic neurons in the ventral tegmental area, but not the substantia nigra, occurs at early pre-plaque stages, and may contribute to impaired cognition and reward processing.
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2017-04-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/ncomms14727 |
| _version_ | 1818681742231339008 |
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| author | Annalisa Nobili Emanuele Claudio Latagliata Maria Teresa Viscomi Virve Cavallucci Debora Cutuli Giacomo Giacovazzo Paraskevi Krashia Francesca Romana Rizzo Ramona Marino Mauro Federici Paola De Bartolo Daniela Aversa Maria Concetta Dell’Acqua Alberto Cordella Marco Sancandi Flavio Keller Laura Petrosini Stefano Puglisi-Allegra Nicola Biagio Mercuri Roberto Coccurello Nicola Berretta Marcello D’Amelio |
| author_facet | Annalisa Nobili Emanuele Claudio Latagliata Maria Teresa Viscomi Virve Cavallucci Debora Cutuli Giacomo Giacovazzo Paraskevi Krashia Francesca Romana Rizzo Ramona Marino Mauro Federici Paola De Bartolo Daniela Aversa Maria Concetta Dell’Acqua Alberto Cordella Marco Sancandi Flavio Keller Laura Petrosini Stefano Puglisi-Allegra Nicola Biagio Mercuri Roberto Coccurello Nicola Berretta Marcello D’Amelio |
| author_sort | Annalisa Nobili |
| collection | DOAJ |
| description | Dopaminergic dysfunction occurs in Alzheimer’s disease (AD). The authors show that in a mouse model of AD, loss of dopaminergic neurons in the ventral tegmental area, but not the substantia nigra, occurs at early pre-plaque stages, and may contribute to impaired cognition and reward processing. |
| first_indexed | 2024-12-17T10:07:47Z |
| format | Article |
| id | doaj.art-0bfe3928a258483cb4eba1b96c8e6f16 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-17T10:07:47Z |
| publishDate | 2017-04-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-0bfe3928a258483cb4eba1b96c8e6f162022-12-21T21:53:07ZengNature PortfolioNature Communications2041-17232017-04-018111410.1038/ncomms14727Dopamine neuronal loss contributes to memory and reward dysfunction in a model of Alzheimer’s diseaseAnnalisa Nobili0Emanuele Claudio Latagliata1Maria Teresa Viscomi2Virve Cavallucci3Debora Cutuli4Giacomo Giacovazzo5Paraskevi Krashia6Francesca Romana Rizzo7Ramona Marino8Mauro Federici9Paola De Bartolo10Daniela Aversa11Maria Concetta Dell’Acqua12Alberto Cordella13Marco Sancandi14Flavio Keller15Laura Petrosini16Stefano Puglisi-Allegra17Nicola Biagio Mercuri18Roberto Coccurello19Nicola Berretta20Marcello D’Amelio21Department of Experimental Neurosciences, IRCCS Santa Lucia FoundationDepartment of Experimental Neurosciences, IRCCS Santa Lucia FoundationDepartment of Experimental Neurosciences, IRCCS Santa Lucia FoundationDepartment of Experimental Neurosciences, IRCCS Santa Lucia FoundationDepartment of Experimental Neurosciences, IRCCS Santa Lucia FoundationDepartment of Experimental Neurosciences, IRCCS Santa Lucia FoundationDepartment of Experimental Neurosciences, IRCCS Santa Lucia FoundationDepartment of Experimental Neurosciences, IRCCS Santa Lucia FoundationDepartment of Medicine, Unit of Molecular Neurosciences, University Campus-BiomedicoDepartment of Experimental Neurosciences, IRCCS Santa Lucia FoundationDepartment of Experimental Neurosciences, IRCCS Santa Lucia FoundationDepartment of Experimental Neurosciences, IRCCS Santa Lucia FoundationDepartment of Experimental Neurosciences, IRCCS Santa Lucia FoundationDepartment of Experimental Neurosciences, IRCCS Santa Lucia FoundationDepartment of Psychology, University SapienzaDepartment of Medicine, Laboratory of Developmental Neuroscience and Neural Plasticity, University Campus-BiomedicoDepartment of Experimental Neurosciences, IRCCS Santa Lucia FoundationDepartment of Experimental Neurosciences, IRCCS Santa Lucia FoundationDepartment of Experimental Neurosciences, IRCCS Santa Lucia FoundationDepartment of Experimental Neurosciences, IRCCS Santa Lucia FoundationDepartment of Experimental Neurosciences, IRCCS Santa Lucia FoundationDepartment of Experimental Neurosciences, IRCCS Santa Lucia FoundationDopaminergic dysfunction occurs in Alzheimer’s disease (AD). The authors show that in a mouse model of AD, loss of dopaminergic neurons in the ventral tegmental area, but not the substantia nigra, occurs at early pre-plaque stages, and may contribute to impaired cognition and reward processing.https://doi.org/10.1038/ncomms14727 |
| spellingShingle | Annalisa Nobili Emanuele Claudio Latagliata Maria Teresa Viscomi Virve Cavallucci Debora Cutuli Giacomo Giacovazzo Paraskevi Krashia Francesca Romana Rizzo Ramona Marino Mauro Federici Paola De Bartolo Daniela Aversa Maria Concetta Dell’Acqua Alberto Cordella Marco Sancandi Flavio Keller Laura Petrosini Stefano Puglisi-Allegra Nicola Biagio Mercuri Roberto Coccurello Nicola Berretta Marcello D’Amelio Dopamine neuronal loss contributes to memory and reward dysfunction in a model of Alzheimer’s disease Nature Communications |
| title | Dopamine neuronal loss contributes to memory and reward dysfunction in a model of Alzheimer’s disease |
| title_full | Dopamine neuronal loss contributes to memory and reward dysfunction in a model of Alzheimer’s disease |
| title_fullStr | Dopamine neuronal loss contributes to memory and reward dysfunction in a model of Alzheimer’s disease |
| title_full_unstemmed | Dopamine neuronal loss contributes to memory and reward dysfunction in a model of Alzheimer’s disease |
| title_short | Dopamine neuronal loss contributes to memory and reward dysfunction in a model of Alzheimer’s disease |
| title_sort | dopamine neuronal loss contributes to memory and reward dysfunction in a model of alzheimer s disease |
| url | https://doi.org/10.1038/ncomms14727 |
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