The Promising Role of Mushrooms as a Therapeutic Adjuvant of Conventional Cancer Therapies

Complementary and alternative medicine (CAM) has been fronted as an alternative due to its potential for holistic treatment. Many CAMs are plant-derived, including algae and mushrooms that have been used widely in many parts of the world, where they are regarded as biological response modifiers. The...

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Main Authors: Ana Isabel Plácido, Fátima Roque, Manuel Morgado
Format: Article
Language:English
Published: MDPI AG 2022-01-01
Series:Biologics
Subjects:
Online Access:https://www.mdpi.com/2673-8449/2/1/5
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author Ana Isabel Plácido
Fátima Roque
Manuel Morgado
author_facet Ana Isabel Plácido
Fátima Roque
Manuel Morgado
author_sort Ana Isabel Plácido
collection DOAJ
description Complementary and alternative medicine (CAM) has been fronted as an alternative due to its potential for holistic treatment. Many CAMs are plant-derived, including algae and mushrooms that have been used widely in many parts of the world, where they are regarded as biological response modifiers. The purpose of this article was to review the role of mushrooms as an adjuvant in conventional therapies, to reveal the therapeutic substances of mushrooms as an adjuvant in conventional therapies, to bring together the available scientific data on the medical effects of mushrooms in oncology, and verify its efficacy and safety. A literature search was conducted in September 2021 on the MEDLINE-PubMed and Cochrane databases to identify relevant randomized controlled trials or clinical trials studies addressing the use of whole mushroom formulations as complementary therapy during conventional cancer treatment.: The findings from the present study suggest that mushrooms may act as a potentiator of host defense mechanisms and decrease adverse events for patients with cancer undergoing conventional therapies. New protocols to conduct clinical trials are needed to elucidate the possible active mechanisms and clinical benefits of these fungi in various types of cancer.
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spelling doaj.art-0bfe71eee4064f01a2cf832424751a812023-11-24T00:30:32ZengMDPI AGBiologics2673-84492022-01-0121586810.3390/biologics2010005The Promising Role of Mushrooms as a Therapeutic Adjuvant of Conventional Cancer TherapiesAna Isabel Plácido0Fátima Roque1Manuel Morgado2Health Sciences School, Polytechnic of Guarda, Rua da Cadeia, 6300-035 Guarda, PortugalHealth Sciences School, Polytechnic of Guarda, Rua da Cadeia, 6300-035 Guarda, PortugalHealth Sciences School, Polytechnic of Guarda, Rua da Cadeia, 6300-035 Guarda, PortugalComplementary and alternative medicine (CAM) has been fronted as an alternative due to its potential for holistic treatment. Many CAMs are plant-derived, including algae and mushrooms that have been used widely in many parts of the world, where they are regarded as biological response modifiers. The purpose of this article was to review the role of mushrooms as an adjuvant in conventional therapies, to reveal the therapeutic substances of mushrooms as an adjuvant in conventional therapies, to bring together the available scientific data on the medical effects of mushrooms in oncology, and verify its efficacy and safety. A literature search was conducted in September 2021 on the MEDLINE-PubMed and Cochrane databases to identify relevant randomized controlled trials or clinical trials studies addressing the use of whole mushroom formulations as complementary therapy during conventional cancer treatment.: The findings from the present study suggest that mushrooms may act as a potentiator of host defense mechanisms and decrease adverse events for patients with cancer undergoing conventional therapies. New protocols to conduct clinical trials are needed to elucidate the possible active mechanisms and clinical benefits of these fungi in various types of cancer.https://www.mdpi.com/2673-8449/2/1/5adjuvantcancerconventional therapymushroom
spellingShingle Ana Isabel Plácido
Fátima Roque
Manuel Morgado
The Promising Role of Mushrooms as a Therapeutic Adjuvant of Conventional Cancer Therapies
Biologics
adjuvant
cancer
conventional therapy
mushroom
title The Promising Role of Mushrooms as a Therapeutic Adjuvant of Conventional Cancer Therapies
title_full The Promising Role of Mushrooms as a Therapeutic Adjuvant of Conventional Cancer Therapies
title_fullStr The Promising Role of Mushrooms as a Therapeutic Adjuvant of Conventional Cancer Therapies
title_full_unstemmed The Promising Role of Mushrooms as a Therapeutic Adjuvant of Conventional Cancer Therapies
title_short The Promising Role of Mushrooms as a Therapeutic Adjuvant of Conventional Cancer Therapies
title_sort promising role of mushrooms as a therapeutic adjuvant of conventional cancer therapies
topic adjuvant
cancer
conventional therapy
mushroom
url https://www.mdpi.com/2673-8449/2/1/5
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