Sarcorucinine-D Inhibits Cholinesterases and Calcium Channels: Molecular Dynamics Simulation and In Vitro Mechanistic Investigations

Sarcorucinine-D Inhibits Cholinesterases and Calcium Channels: Molecular Dynamics Simulation and In Vitro Mechanistic Investigations

Acetylcholinesterase (AChE) inhibitors and calcium channel blockers are considered effective therapies for Alzheimer’s disease. AChE plays an essential role in the nervous system by catalyzing the hydrolysis of the neurotransmitter acetylcholine. In this study, the inhibition of the enzyme AChE by S...

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Bibliographic Details
Main Authors: Asaad Khalid, Mohnad Abdalla, Maria Saeed, Muhammad Nabeel Ghayur, Surya Kant Kalauni, Mohammed Albratty, Hassan A. Alhazmi, Mohammed Ahmed Mesaik, Anwarul Hassan Gilani, Zaheer Ul-Haq
Format: Article
Language:English
Published: MDPI AG 2022-05-01
Series:Molecules
Subjects:
acetylcholinesterase
butyrylcholinesterase
steroidal alkaloids
inhibition kinetics
molecular dynamics simulation
ligand-protein docking
Online Access:https://www.mdpi.com/1420-3049/27/11/3361

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