Toward the elimination of hepatitis B: networking to promote the prevention of vertical transmission of hepatitis B virus through population-based interventions and multidisciplinary groups in Africa
The WHO African Region had 81 million people with chronic hepatitis B in 2019, which remains a silent killer. Hepatitis B virus (HBV), hepatitis delta virus (HDV), and HIV can be transmitted from the mother to child. If the HBV infection is acquired at infancy, it may lead to chronic hepatitis B in...
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| Format: | Article |
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Frontiers Media S.A.
2024-04-01
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| Series: | Frontiers in Public Health |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpubh.2024.1283350/full |
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| author | Judith Ndongo Embola Torimiro Judith Ndongo Embola Torimiro Kerina Duri Nadège M. Goumkwa Solange M. Atah Juliette-Laure Ndzie Ondigui Cindy Lobe Cindy Lobe Marielle Bouyou Bénédicte Ndeboko Bénédicte Ndeboko Ali Mahamat Moussa Camengo Police Patrick Awoumou Patrick Awoumou Puinta Peyonga Prisca V. Djivida Assah Felix Godwin W. Nchinda Brigitte Wandji Rachel K. Simo Sylvie Agnès Moudourou Ana Gutierrez Rosi Garcia Isabelle Fernandez Evelyn Mah Evelyn Mah Sarah Rowland-Jones Sarah Rowland-Jones Robinson Mbu Robinson Mbu |
| author_facet | Judith Ndongo Embola Torimiro Judith Ndongo Embola Torimiro Kerina Duri Nadège M. Goumkwa Solange M. Atah Juliette-Laure Ndzie Ondigui Cindy Lobe Cindy Lobe Marielle Bouyou Bénédicte Ndeboko Bénédicte Ndeboko Ali Mahamat Moussa Camengo Police Patrick Awoumou Patrick Awoumou Puinta Peyonga Prisca V. Djivida Assah Felix Godwin W. Nchinda Brigitte Wandji Rachel K. Simo Sylvie Agnès Moudourou Ana Gutierrez Rosi Garcia Isabelle Fernandez Evelyn Mah Evelyn Mah Sarah Rowland-Jones Sarah Rowland-Jones Robinson Mbu Robinson Mbu |
| author_sort | Judith Ndongo Embola Torimiro |
| collection | DOAJ |
| description | The WHO African Region had 81 million people with chronic hepatitis B in 2019, which remains a silent killer. Hepatitis B virus (HBV), hepatitis delta virus (HDV), and HIV can be transmitted from the mother to child. If the HBV infection is acquired at infancy, it may lead to chronic hepatitis B in 90% of the cases. WHO reports that 6.4 million children under 5 years live with chronic hepatitis B infection worldwide. The prevention of mother-to-child transmission (PMTCT) of HBV is therefore critical in the global elimination strategy of viral hepatitis as we take lessons from PMTCT of HIV programs in Africa. We sought to create a network of multidisciplinary professional and civil society volunteers with the vision to promote cost-effective, country-driven initiatives to prevent the MTCT of HBV in Africa. In 2018, the Mother–Infant Cohort Hepatitis B Network (MICHep B Network) with members from Cameroon, Zimbabwe, and the United Kingdom and later from Chad, Gabon, and Central African Republic was created. The long-term objectives of the network are to organize capacity-building and networking workshops, create awareness among pregnant women, their partners, and the community, promote the operational research on MTCT of HBV, and extend the network activities to other African countries. The Network organized in Cameroon, two “Knowledge, Attitude and Practice” (KAP) surveys, one in-depth interview of 45 health care workers which revealed a high acceptability of the hepatitis B vaccine by families, two in-person workshops in 2018 and 2019, and one virtual in 2021 with over 190 participants, as well as two workshops on grant writing, bioethics, and biostatistics of 30 postgraduate students. Two HBV seroprevalence studies in pregnant women were conducted in Cameroon and Zimbabwe, in which a prevalence of 5.8% and 2.7%, respectively, was reported. The results and recommendations from the MICHep B Network activities could be implemented in countries of the MICHep B Network and beyond, with the goal of providing free birth dose vaccine against hepatitis B in Africa. |
| first_indexed | 2024-04-24T13:09:11Z |
| format | Article |
| id | doaj.art-0bfe94cac1144d20a0ffaebad6a5bfcf |
| institution | Directory Open Access Journal |
| issn | 2296-2565 |
| language | English |
| last_indexed | 2024-04-24T13:09:11Z |
| publishDate | 2024-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Public Health |
| spelling | doaj.art-0bfe94cac1144d20a0ffaebad6a5bfcf2024-04-05T04:59:55ZengFrontiers Media S.A.Frontiers in Public Health2296-25652024-04-011210.3389/fpubh.2024.12833501283350Toward the elimination of hepatitis B: networking to promote the prevention of vertical transmission of hepatitis B virus through population-based interventions and multidisciplinary groups in AfricaJudith Ndongo Embola Torimiro0Judith Ndongo Embola Torimiro1Kerina Duri2Nadège M. Goumkwa3Solange M. Atah4Juliette-Laure Ndzie Ondigui5Cindy Lobe6Cindy Lobe7Marielle Bouyou8Bénédicte Ndeboko9Bénédicte Ndeboko10Ali Mahamat Moussa11Camengo Police12Patrick Awoumou13Patrick Awoumou14Puinta Peyonga15Prisca V. Djivida16Assah Felix17Godwin W. Nchinda18Brigitte Wandji19Rachel K. Simo20Sylvie Agnès Moudourou21Ana Gutierrez22Rosi Garcia23Isabelle Fernandez24Evelyn Mah25Evelyn Mah26Sarah Rowland-Jones27Sarah Rowland-Jones28 Robinson Mbu29 Robinson Mbu30Molecular Biology Laboratory, Chantal BIYA International Reference Center for Research on HIV/AIDS Prevention and Management (CIRCB), Yaoundé, CameroonDepartment of Biochemistry, Faculty of Medicine and Biomedical Sciences, University of Yaoundé I, Yaoundé, CameroonDepartment of Immunology, College of Health Sciences, University of Zimbabwe, Harare, ZimbabweMolecular Biology Laboratory, Chantal BIYA International Reference Center for Research on HIV/AIDS Prevention and Management (CIRCB), Yaoundé, CameroonDepartment of Public Health, Faculty of Medicine and Biomedical Sciences, University of Yaoundé I, Yaoundé, CameroonDepartment of Microbiology, Faculty of Science, University of Yaoundé I, Yaoundé, CameroonMolecular Biology Laboratory, Chantal BIYA International Reference Center for Research on HIV/AIDS Prevention and Management (CIRCB), Yaoundé, CameroonDepartment of Food Science and Nutrition, University of Ngaoundere, Ngaoundere, CameroonDepartment of Parasitology, Mycology and Tropical Medicine, University of Health Sciences, Libreville, GabonDepartment of Cell and Molecular Biology-Genetics, Faculty of Medicine, University of Health Sciences, Libreville, GabonCentre Hospitalier Universitaire Mère-Enfant de la Fondation Jeanne EBORI (CHUMEFJE), Libreville, Gabon0Gastroenterology and Internal Medicine Unit, University Reference Hospital, Gamena, Chad1Department of Hepato-Gastroenterology and Internal Medicine of “Amitié Sino Centrafraine”, University Hospital Center, Bangui, Central African RepublicMolecular Biology Laboratory, Chantal BIYA International Reference Center for Research on HIV/AIDS Prevention and Management (CIRCB), Yaoundé, CameroonDepartment of Biochemistry, Faculty of Medicine and Biomedical Sciences, University of Yaoundé I, Yaoundé, CameroonDepartment of Biochemistry, Faculty of Medicine and Biomedical Sciences, University of Yaoundé I, Yaoundé, CameroonDepartment of Biochemistry, Faculty of Medicine and Biomedical Sciences, University of Yaoundé I, Yaoundé, CameroonDepartment of Public Health, Faculty of Medicine and Biomedical Sciences, University of Yaoundé I, Yaoundé, Cameroon2Vaccinology Laboratory, Chantal BIYA International Reference Center for Research on HIV/AIDS Prevention and Management (CIRCB), Yaoundé, Cameroon3Yaoundé Gynaecology, Obstetrics and Pediatrics Hospital, Yaoundé, Cameroon4Clinical Diagnostic Laboratory, Chantal BIYA International Reference Center for Research on HIV/AIDS Prevention and Management (CIRCB), Yaoundé, Cameroon5Medical Unit, Chantal BIYA International Reference Center for Research on HIV/AIDS Prevention and Management (CIRCB), Yaoundé, Cameroon6Bikop Catholic Health Center, Bikop, Cameroon6Bikop Catholic Health Center, Bikop, Cameroon6Bikop Catholic Health Center, Bikop, Cameroon3Yaoundé Gynaecology, Obstetrics and Pediatrics Hospital, Yaoundé, Cameroon7Department of Paediatrics, Faculty of Medicine and Biomedical Sciences, University of Yaoundé I, Yaoundé, Cameroon8Nuffield Department of Medicine, Medical Sciences Division, University of Oxford, Oxford, United KingdomMolecular Biology Laboratory, Chantal BIYA International Reference Center for Research on HIV/AIDS Prevention and Management (CIRCB), Yaoundé, Cameroon3Yaoundé Gynaecology, Obstetrics and Pediatrics Hospital, Yaoundé, Cameroon9Department of Gynaecology and Obstetrics, Faculty of Medicine and Biomedical Sciences, University of Yaoundé I, Yaoundé, CameroonThe WHO African Region had 81 million people with chronic hepatitis B in 2019, which remains a silent killer. Hepatitis B virus (HBV), hepatitis delta virus (HDV), and HIV can be transmitted from the mother to child. If the HBV infection is acquired at infancy, it may lead to chronic hepatitis B in 90% of the cases. WHO reports that 6.4 million children under 5 years live with chronic hepatitis B infection worldwide. The prevention of mother-to-child transmission (PMTCT) of HBV is therefore critical in the global elimination strategy of viral hepatitis as we take lessons from PMTCT of HIV programs in Africa. We sought to create a network of multidisciplinary professional and civil society volunteers with the vision to promote cost-effective, country-driven initiatives to prevent the MTCT of HBV in Africa. In 2018, the Mother–Infant Cohort Hepatitis B Network (MICHep B Network) with members from Cameroon, Zimbabwe, and the United Kingdom and later from Chad, Gabon, and Central African Republic was created. The long-term objectives of the network are to organize capacity-building and networking workshops, create awareness among pregnant women, their partners, and the community, promote the operational research on MTCT of HBV, and extend the network activities to other African countries. The Network organized in Cameroon, two “Knowledge, Attitude and Practice” (KAP) surveys, one in-depth interview of 45 health care workers which revealed a high acceptability of the hepatitis B vaccine by families, two in-person workshops in 2018 and 2019, and one virtual in 2021 with over 190 participants, as well as two workshops on grant writing, bioethics, and biostatistics of 30 postgraduate students. Two HBV seroprevalence studies in pregnant women were conducted in Cameroon and Zimbabwe, in which a prevalence of 5.8% and 2.7%, respectively, was reported. The results and recommendations from the MICHep B Network activities could be implemented in countries of the MICHep B Network and beyond, with the goal of providing free birth dose vaccine against hepatitis B in Africa.https://www.frontiersin.org/articles/10.3389/fpubh.2024.1283350/fullhepatitis Bbirth-dosevaccineverticaltransmissionprevention |
| spellingShingle | Judith Ndongo Embola Torimiro Judith Ndongo Embola Torimiro Kerina Duri Nadège M. Goumkwa Solange M. Atah Juliette-Laure Ndzie Ondigui Cindy Lobe Cindy Lobe Marielle Bouyou Bénédicte Ndeboko Bénédicte Ndeboko Ali Mahamat Moussa Camengo Police Patrick Awoumou Patrick Awoumou Puinta Peyonga Prisca V. Djivida Assah Felix Godwin W. Nchinda Brigitte Wandji Rachel K. Simo Sylvie Agnès Moudourou Ana Gutierrez Rosi Garcia Isabelle Fernandez Evelyn Mah Evelyn Mah Sarah Rowland-Jones Sarah Rowland-Jones Robinson Mbu Robinson Mbu Toward the elimination of hepatitis B: networking to promote the prevention of vertical transmission of hepatitis B virus through population-based interventions and multidisciplinary groups in Africa Frontiers in Public Health hepatitis B birth-dose vaccine vertical transmission prevention |
| title | Toward the elimination of hepatitis B: networking to promote the prevention of vertical transmission of hepatitis B virus through population-based interventions and multidisciplinary groups in Africa |
| title_full | Toward the elimination of hepatitis B: networking to promote the prevention of vertical transmission of hepatitis B virus through population-based interventions and multidisciplinary groups in Africa |
| title_fullStr | Toward the elimination of hepatitis B: networking to promote the prevention of vertical transmission of hepatitis B virus through population-based interventions and multidisciplinary groups in Africa |
| title_full_unstemmed | Toward the elimination of hepatitis B: networking to promote the prevention of vertical transmission of hepatitis B virus through population-based interventions and multidisciplinary groups in Africa |
| title_short | Toward the elimination of hepatitis B: networking to promote the prevention of vertical transmission of hepatitis B virus through population-based interventions and multidisciplinary groups in Africa |
| title_sort | toward the elimination of hepatitis b networking to promote the prevention of vertical transmission of hepatitis b virus through population based interventions and multidisciplinary groups in africa |
| topic | hepatitis B birth-dose vaccine vertical transmission prevention |
| url | https://www.frontiersin.org/articles/10.3389/fpubh.2024.1283350/full |
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