Изучение количества циркулирующих прогениторных клеток эндотелия у больных сахарным диабетом 1 типа
Aim. Circulating progenitor endothelial cells (CPCs) play an important role in the regeneration of damaged vascular endothelium. We aimed to study the effect of type 1 diabetes mellitus (DM) on the number of different lines of CPCs.Methods. The number of different lines of CPCs was evaluated by flow...
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| Format: | Article |
| Language: | English |
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Endocrinology Research Centre
2015-10-01
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| Series: | Сахарный диабет |
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| Online Access: | https://www.dia-endojournals.ru/jour/article/view/7185 |
| _version_ | 1797255187862126592 |
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| author | Angelina Valerievna Sokolova Tatyana Nikolaevna Kochegura Elena Viktorovna Parfyonova Marina Vladimirovna Shestakova |
| author_facet | Angelina Valerievna Sokolova Tatyana Nikolaevna Kochegura Elena Viktorovna Parfyonova Marina Vladimirovna Shestakova |
| author_sort | Angelina Valerievna Sokolova |
| collection | DOAJ |
| description | Aim. Circulating progenitor endothelial cells (CPCs) play an important role in the regeneration of damaged vascular endothelium. We aimed to study the effect of type 1 diabetes mellitus (DM) on the number of different lines of CPCs.Methods. The number of different lines of CPCs was evaluated by flow cytometry in 45 patients with type 1 DM (mean age: 26,6±6,5 years) of different duration and 14 healthy volunteers.Results. The number of CPCs in the peripheral blood flow of patients with type 1 DM was significanlty reduced compared with that in healthy volunteers and had a reliable inverse correlation with glycated haemoglobin (HbA1c).Conclusions. The number of CPCs in the peripheral blood flow of patients with type 1 DM depended on the level of DM compensation. Of the different lines of CPCs, Lin-CD34+ cells were significantly reduced by 42% (p=0,006), Lin-CD34+c-Kit- cells by 42% (p=0,007) and Lin-CD34+c-Kit+ cells by 41% (p=0,022). Thus, the number of CPCs in the peripheral blood of patients with type 1 DM is reduced with higher levels of HbA1c. |
| first_indexed | 2024-03-08T15:20:56Z |
| format | Article |
| id | doaj.art-0bff0004d58a495ea14a56f7ef8adad9 |
| institution | Directory Open Access Journal |
| issn | 2072-0351 2072-0378 |
| language | English |
| last_indexed | 2024-04-24T22:01:52Z |
| publishDate | 2015-10-01 |
| publisher | Endocrinology Research Centre |
| record_format | Article |
| series | Сахарный диабет |
| spelling | doaj.art-0bff0004d58a495ea14a56f7ef8adad92024-03-20T11:48:00ZengEndocrinology Research CentreСахарный диабет2072-03512072-03782015-10-01183515610.14341/DM2015351-566810Изучение количества циркулирующих прогениторных клеток эндотелия у больных сахарным диабетом 1 типаAngelina Valerievna Sokolova0Tatyana Nikolaevna Kochegura1Elena Viktorovna Parfyonova2Marina Vladimirovna Shestakova3Endocrinological Research CentreLomonosov Moscow State UniversityRussian Cardiological Research and Production ComplexEndocrinological Research Centre; Sechenov First Moscow State Medical UniversityAim. Circulating progenitor endothelial cells (CPCs) play an important role in the regeneration of damaged vascular endothelium. We aimed to study the effect of type 1 diabetes mellitus (DM) on the number of different lines of CPCs.Methods. The number of different lines of CPCs was evaluated by flow cytometry in 45 patients with type 1 DM (mean age: 26,6±6,5 years) of different duration and 14 healthy volunteers.Results. The number of CPCs in the peripheral blood flow of patients with type 1 DM was significanlty reduced compared with that in healthy volunteers and had a reliable inverse correlation with glycated haemoglobin (HbA1c).Conclusions. The number of CPCs in the peripheral blood flow of patients with type 1 DM depended on the level of DM compensation. Of the different lines of CPCs, Lin-CD34+ cells were significantly reduced by 42% (p=0,006), Lin-CD34+c-Kit- cells by 42% (p=0,007) and Lin-CD34+c-Kit+ cells by 41% (p=0,022). Thus, the number of CPCs in the peripheral blood of patients with type 1 DM is reduced with higher levels of HbA1c.https://www.dia-endojournals.ru/jour/article/view/7185circulating progenitor cellsdiabetes mellitus 1 typedisfunction of endothelium |
| spellingShingle | Angelina Valerievna Sokolova Tatyana Nikolaevna Kochegura Elena Viktorovna Parfyonova Marina Vladimirovna Shestakova Изучение количества циркулирующих прогениторных клеток эндотелия у больных сахарным диабетом 1 типа Сахарный диабет circulating progenitor cells diabetes mellitus 1 type disfunction of endothelium |
| title | Изучение количества циркулирующих прогениторных клеток эндотелия у больных сахарным диабетом 1 типа |
| title_full | Изучение количества циркулирующих прогениторных клеток эндотелия у больных сахарным диабетом 1 типа |
| title_fullStr | Изучение количества циркулирующих прогениторных клеток эндотелия у больных сахарным диабетом 1 типа |
| title_full_unstemmed | Изучение количества циркулирующих прогениторных клеток эндотелия у больных сахарным диабетом 1 типа |
| title_short | Изучение количества циркулирующих прогениторных клеток эндотелия у больных сахарным диабетом 1 типа |
| title_sort | изучение количества циркулирующих прогениторных клеток эндотелия у больных сахарным диабетом 1 типа |
| topic | circulating progenitor cells diabetes mellitus 1 type disfunction of endothelium |
| url | https://www.dia-endojournals.ru/jour/article/view/7185 |
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