Ethionamide-induced gynecomastia: A rare case report

Abstract Gynecomastia is a rare side effect of antitubercular chemotherapy. A 22-year-old male patient was diagnosed as a multidrug-resistant tuberculosis case and was put on standard second-line antituberculosis drugs. Two months later, the patient developed painful enlarged left breast with size 2...

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Main Authors: Sourindra N. Banerjee, Rupam K. Ta, Md. Salim Mallick, Manish K. Munda
Format: Article
Language:English
Published: SpringerOpen 2017-01-01
Series:The Egyptian Journal of Bronchology
Subjects:
Online Access:http://link.springer.com/article/10.4103/1687-8426.198998
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author Sourindra N. Banerjee
Rupam K. Ta
Md. Salim Mallick
Manish K. Munda
author_facet Sourindra N. Banerjee
Rupam K. Ta
Md. Salim Mallick
Manish K. Munda
author_sort Sourindra N. Banerjee
collection DOAJ
description Abstract Gynecomastia is a rare side effect of antitubercular chemotherapy. A 22-year-old male patient was diagnosed as a multidrug-resistant tuberculosis case and was put on standard second-line antituberculosis drugs. Two months later, the patient developed painful enlarged left breast with size 2×3cm2, mobile, tender, and normal nipple-areola without any discharge. Common endocrinological and biochemical tests were normal. Ethionamide-induced gynecomastia was suspected. Ultrasonography of the breast showed hypoechoic shadow suggesting glandular tissue hyperplasia without any deeper tissue infiltration. On discontinuing ethionamide, gynecomastia reduced gradually. On reintroduction, gynecomastia reappeared and again disappeared within weeks after withdrawal. Thus, painful gynecomastia induced by ethionamide was concluded. We report this case of unilateral painful gynecomastia because of its rarity and for the purpose of documentation and awareness.
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spelling doaj.art-0bff19bbb4ba417bb4b26141258ab63d2022-12-21T18:51:33ZengSpringerOpenThe Egyptian Journal of Bronchology1687-84262314-85512017-01-01111707310.4103/1687-8426.198998Ethionamide-induced gynecomastia: A rare case reportSourindra N. Banerjee0Rupam K. Ta1Md. Salim Mallick2Manish K. Munda3Department of Chest Medicine, Burdwan Medical College and HospitalDepartment of Chest Medicine, Burdwan Medical College and HospitalDepartment of Chest Medicine, Burdwan Medical College and HospitalDepartment of Chest Medicine, Burdwan Medical College and HospitalAbstract Gynecomastia is a rare side effect of antitubercular chemotherapy. A 22-year-old male patient was diagnosed as a multidrug-resistant tuberculosis case and was put on standard second-line antituberculosis drugs. Two months later, the patient developed painful enlarged left breast with size 2×3cm2, mobile, tender, and normal nipple-areola without any discharge. Common endocrinological and biochemical tests were normal. Ethionamide-induced gynecomastia was suspected. Ultrasonography of the breast showed hypoechoic shadow suggesting glandular tissue hyperplasia without any deeper tissue infiltration. On discontinuing ethionamide, gynecomastia reduced gradually. On reintroduction, gynecomastia reappeared and again disappeared within weeks after withdrawal. Thus, painful gynecomastia induced by ethionamide was concluded. We report this case of unilateral painful gynecomastia because of its rarity and for the purpose of documentation and awareness.http://link.springer.com/article/10.4103/1687-8426.198998ethionamidegynecomastiamultidrug-resistant tuberculosis
spellingShingle Sourindra N. Banerjee
Rupam K. Ta
Md. Salim Mallick
Manish K. Munda
Ethionamide-induced gynecomastia: A rare case report
The Egyptian Journal of Bronchology
ethionamide
gynecomastia
multidrug-resistant tuberculosis
title Ethionamide-induced gynecomastia: A rare case report
title_full Ethionamide-induced gynecomastia: A rare case report
title_fullStr Ethionamide-induced gynecomastia: A rare case report
title_full_unstemmed Ethionamide-induced gynecomastia: A rare case report
title_short Ethionamide-induced gynecomastia: A rare case report
title_sort ethionamide induced gynecomastia a rare case report
topic ethionamide
gynecomastia
multidrug-resistant tuberculosis
url http://link.springer.com/article/10.4103/1687-8426.198998
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AT rupamkta ethionamideinducedgynecomastiaararecasereport
AT mdsalimmallick ethionamideinducedgynecomastiaararecasereport
AT manishkmunda ethionamideinducedgynecomastiaararecasereport