Short-Term Effect of Micropulse Transscleral Laser Therapy on Intraocular Pressure in Untreated Fellow Eyes of Glaucoma Patients: Preliminary Results
It has been observed that an intraocular pressure (IOP) altering intervention in one eye is followed by a consensual response in the untreated fellow eye. The underlying mechanisms remain unclear. Involvement of neuronal, cytokine, and hormonal regulation of aqueous humor dynamics, as well as improv...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-05-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/12/11/3680 |
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| author | Laura L. Fortuna Thomas Dervos Zisis Gatzioufas Hendrik P. N. Scholl Konstantin Gugleta Tim J. Enz |
| author_facet | Laura L. Fortuna Thomas Dervos Zisis Gatzioufas Hendrik P. N. Scholl Konstantin Gugleta Tim J. Enz |
| author_sort | Laura L. Fortuna |
| collection | DOAJ |
| description | It has been observed that an intraocular pressure (IOP) altering intervention in one eye is followed by a consensual response in the untreated fellow eye. The underlying mechanisms remain unclear. Involvement of neuronal, cytokine, and hormonal regulation of aqueous humor dynamics, as well as improved treatment adherence or systemic absorption of topically administered medical compounds, have been suggested. Our aim was to investigate the short-term effects of unilateral micropulse transscleral laser therapy on IOP in the fellow eye. All medical records of glaucoma patients who underwent micropulse transscleral laser therapy in a tertiary referral center between May 2019 and February 2023 were collected and analyzed. We found a significant reduction in IOP in the treated eyes, indicating successful treatment. In the fellow eyes, despite not having changed any of the pharmacological IOP-reducing therapies, a significant reduction in IOP from 17.0 ± 5.1 mmHg to 13.5 ± 4.4 mmHg (<i>p</i> < 0.01) was observed. This reduction was, however, short-term and reached statistical significance on the first postoperative day only. Our findings support the concept of consensual inter-eye responses to unilateral IOP changes. Further research is warranted to elucidate the mechanisms underlying this phenomenon. |
| first_indexed | 2024-03-11T03:04:19Z |
| format | Article |
| id | doaj.art-0c024cd190c14a88b2396a89a34d3a79 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-11T03:04:19Z |
| publishDate | 2023-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-0c024cd190c14a88b2396a89a34d3a792023-11-18T08:04:58ZengMDPI AGJournal of Clinical Medicine2077-03832023-05-011211368010.3390/jcm12113680Short-Term Effect of Micropulse Transscleral Laser Therapy on Intraocular Pressure in Untreated Fellow Eyes of Glaucoma Patients: Preliminary ResultsLaura L. Fortuna0Thomas Dervos1Zisis Gatzioufas2Hendrik P. N. Scholl3Konstantin Gugleta4Tim J. Enz5Department of Ophthalmology, University Hospital Basel, 4056 Basel, SwitzerlandDepartment of Ophthalmology, University Hospital Basel, 4056 Basel, SwitzerlandDepartment of Ophthalmology, University Hospital Basel, 4056 Basel, SwitzerlandDepartment of Ophthalmology, University Hospital Basel, 4056 Basel, SwitzerlandDepartment of Ophthalmology, University Hospital Basel, 4056 Basel, SwitzerlandDepartment of Ophthalmology, University Hospital Basel, 4056 Basel, SwitzerlandIt has been observed that an intraocular pressure (IOP) altering intervention in one eye is followed by a consensual response in the untreated fellow eye. The underlying mechanisms remain unclear. Involvement of neuronal, cytokine, and hormonal regulation of aqueous humor dynamics, as well as improved treatment adherence or systemic absorption of topically administered medical compounds, have been suggested. Our aim was to investigate the short-term effects of unilateral micropulse transscleral laser therapy on IOP in the fellow eye. All medical records of glaucoma patients who underwent micropulse transscleral laser therapy in a tertiary referral center between May 2019 and February 2023 were collected and analyzed. We found a significant reduction in IOP in the treated eyes, indicating successful treatment. In the fellow eyes, despite not having changed any of the pharmacological IOP-reducing therapies, a significant reduction in IOP from 17.0 ± 5.1 mmHg to 13.5 ± 4.4 mmHg (<i>p</i> < 0.01) was observed. This reduction was, however, short-term and reached statistical significance on the first postoperative day only. Our findings support the concept of consensual inter-eye responses to unilateral IOP changes. Further research is warranted to elucidate the mechanisms underlying this phenomenon.https://www.mdpi.com/2077-0383/12/11/3680intraocular pressurefellow eyeconsensual ophthalmotonic reactionmicropulse transscleral laser treatment |
| spellingShingle | Laura L. Fortuna Thomas Dervos Zisis Gatzioufas Hendrik P. N. Scholl Konstantin Gugleta Tim J. Enz Short-Term Effect of Micropulse Transscleral Laser Therapy on Intraocular Pressure in Untreated Fellow Eyes of Glaucoma Patients: Preliminary Results Journal of Clinical Medicine intraocular pressure fellow eye consensual ophthalmotonic reaction micropulse transscleral laser treatment |
| title | Short-Term Effect of Micropulse Transscleral Laser Therapy on Intraocular Pressure in Untreated Fellow Eyes of Glaucoma Patients: Preliminary Results |
| title_full | Short-Term Effect of Micropulse Transscleral Laser Therapy on Intraocular Pressure in Untreated Fellow Eyes of Glaucoma Patients: Preliminary Results |
| title_fullStr | Short-Term Effect of Micropulse Transscleral Laser Therapy on Intraocular Pressure in Untreated Fellow Eyes of Glaucoma Patients: Preliminary Results |
| title_full_unstemmed | Short-Term Effect of Micropulse Transscleral Laser Therapy on Intraocular Pressure in Untreated Fellow Eyes of Glaucoma Patients: Preliminary Results |
| title_short | Short-Term Effect of Micropulse Transscleral Laser Therapy on Intraocular Pressure in Untreated Fellow Eyes of Glaucoma Patients: Preliminary Results |
| title_sort | short term effect of micropulse transscleral laser therapy on intraocular pressure in untreated fellow eyes of glaucoma patients preliminary results |
| topic | intraocular pressure fellow eye consensual ophthalmotonic reaction micropulse transscleral laser treatment |
| url | https://www.mdpi.com/2077-0383/12/11/3680 |
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