| Summary: | <i>Background:</i> Asthma may be considered as a non-communicable condition associated with higher bronchial responsiveness that may impair quality of life (QoL). <i>Purpose:</i> The research aim was to compare scores of depression, as well as general and foot health-related QoL, in patients who suffered from asthma with respect to healthy subjects. <i>Methods:</i> A total sample of 152 subjects, median age of 37.00 ± 16.00 years, were recruited from a respiratory and allergy department of a hospital and divided into patients with asthma (<i>n</i> = 76) and healthy subjects (<i>n</i> = 76). The scores of the Spanish foot health status questionnaire (SFHSQ) domains as well as the Spanish Beck’s Depression Inventory (BDI) scores and categories were collected. <i>Results:</i> The only statistically significant difference (<i>p</i> < 0.05) was shown for the difference of the FHSQ footwear domain establishing that patients who suffered from asthma presented a worse QoL related to foot health for footwear (lower FHSQ scores) compared to healthy matched-paired participants (higher FHSQ scores). Regarding the rest of the outcome measurements, there were no statistically significant differences (<i>p</i> > 0.05) for the other FHSQ domains scores as well as the BDI scores and categories. <i>Conclusions:</i> Patients with allergic asthma presented impairment of the QoL related to foot health for footwear, which seemed to be linked to the presence of asthma.
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