Effects of Chronic Exposure to Low Levels of Dietary Aflatoxin B<sub>1</sub> on Growth Performance, Apparent Total Tract Digestibility and Intestinal Health in Pigs
This study aimed to investigate the effects of chronic exposure to low levels of dietary aflatoxin B<sub>1</sub> (AFB<sub>1</sub>) on growth performance, apparent total tract digestibility and intestinal health in pigs. In a 102-day experiment, fourteen barrows (Duroc×Landrac...
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MDPI AG
2021-01-01
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| Series: | Animals |
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| Online Access: | https://www.mdpi.com/2076-2615/11/2/336 |
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| author | Junning Pu Qinghui Yuan Hui Yan Gang Tian Daiwen Chen Jun He Ping Zheng Jie Yu Xiangbing Mao Zhiqing Huang Junqiu Luo Yuheng Luo Bing Yu |
| author_facet | Junning Pu Qinghui Yuan Hui Yan Gang Tian Daiwen Chen Jun He Ping Zheng Jie Yu Xiangbing Mao Zhiqing Huang Junqiu Luo Yuheng Luo Bing Yu |
| author_sort | Junning Pu |
| collection | DOAJ |
| description | This study aimed to investigate the effects of chronic exposure to low levels of dietary aflatoxin B<sub>1</sub> (AFB<sub>1</sub>) on growth performance, apparent total tract digestibility and intestinal health in pigs. In a 102-day experiment, fourteen barrows (Duroc×Landrace×Yorkshire, initial BW = 38.21 ± 0.45 kg) were randomly divided into control (CON, basal diet) and AFB<sub>1</sub> groups (the basal diet supplemented with 280 μg/kg AFB<sub>1</sub>). Results revealed that the AFB<sub>1</sub> exposure decreased the final BW, ADFI and ADG in pigs (<i>p</i> < 0.10). AFB<sub>1</sub> exposure also decreased the apparent total tract digestibility of dry mater and gross energy at 50 to 75 kg and 105 to 135 kg stages, and decreased the apparent total tract digestibility of ether extract at 75 to 105 kg stage (<i>p</i> < 0.05). Meanwhile, AFB<sub>1</sub> exposure increased serum diamine oxidase activity and reduced the mRNA abundance of sodium-glucose cotransporter 1, solute carrier family 7 member 1 and zonula occluden-1 in the jejunal mucosa (<i>p</i> < 0.05). Furthermore, AFB<sub>1</sub> exposure decreased superoxide dismutase activity (<i>p</i> < 0.05) and increased 8-hydroxy-2′-deoxyguanosine content (<i>p</i> < 0.10) in jejunal mucosa. AFB<sub>1</sub> exposure also increased tumor necrosis factor-α, interleukin-1β and transforming growth factor-β mRNA abundance in jejunal mucosa and upregulated <i>Escherichia coli</i> population in colon (<i>p</i> < 0.05). The data indicated that chronic exposure to low levels of dietary AFB<sub>1</sub> suppressed growth performance, reduced the apparent total tract digestibility and damaged intestinal barrier integrity in pigs, which could be associated with the decreased intestinal antioxidant capacity and the increased pro-inflammatory cytokine production. |
| first_indexed | 2024-03-09T03:22:07Z |
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| id | doaj.art-0c03222ed7b44135a72641ece7ced5c6 |
| institution | Directory Open Access Journal |
| issn | 2076-2615 |
| language | English |
| last_indexed | 2024-03-09T03:22:07Z |
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| series | Animals |
| spelling | doaj.art-0c03222ed7b44135a72641ece7ced5c62023-12-03T15:07:49ZengMDPI AGAnimals2076-26152021-01-0111233610.3390/ani11020336Effects of Chronic Exposure to Low Levels of Dietary Aflatoxin B<sub>1</sub> on Growth Performance, Apparent Total Tract Digestibility and Intestinal Health in PigsJunning Pu0Qinghui Yuan1Hui Yan2Gang Tian3Daiwen Chen4Jun He5Ping Zheng6Jie Yu7Xiangbing Mao8Zhiqing Huang9Junqiu Luo10Yuheng Luo11Bing Yu12Institute of Animal Nutrition, Sichuan Agricultural University, Yaan 625014, ChinaInstitute of Animal Nutrition, Sichuan Agricultural University, Yaan 625014, ChinaInstitute of Animal Nutrition, Sichuan Agricultural University, Yaan 625014, ChinaInstitute of Animal Nutrition, Sichuan Agricultural University, Yaan 625014, ChinaInstitute of Animal Nutrition, Sichuan Agricultural University, Yaan 625014, ChinaInstitute of Animal Nutrition, Sichuan Agricultural University, Yaan 625014, ChinaInstitute of Animal Nutrition, Sichuan Agricultural University, Yaan 625014, ChinaInstitute of Animal Nutrition, Sichuan Agricultural University, Yaan 625014, ChinaInstitute of Animal Nutrition, Sichuan Agricultural University, Yaan 625014, ChinaInstitute of Animal Nutrition, Sichuan Agricultural University, Yaan 625014, ChinaInstitute of Animal Nutrition, Sichuan Agricultural University, Yaan 625014, ChinaInstitute of Animal Nutrition, Sichuan Agricultural University, Yaan 625014, ChinaInstitute of Animal Nutrition, Sichuan Agricultural University, Yaan 625014, ChinaThis study aimed to investigate the effects of chronic exposure to low levels of dietary aflatoxin B<sub>1</sub> (AFB<sub>1</sub>) on growth performance, apparent total tract digestibility and intestinal health in pigs. In a 102-day experiment, fourteen barrows (Duroc×Landrace×Yorkshire, initial BW = 38.21 ± 0.45 kg) were randomly divided into control (CON, basal diet) and AFB<sub>1</sub> groups (the basal diet supplemented with 280 μg/kg AFB<sub>1</sub>). Results revealed that the AFB<sub>1</sub> exposure decreased the final BW, ADFI and ADG in pigs (<i>p</i> < 0.10). AFB<sub>1</sub> exposure also decreased the apparent total tract digestibility of dry mater and gross energy at 50 to 75 kg and 105 to 135 kg stages, and decreased the apparent total tract digestibility of ether extract at 75 to 105 kg stage (<i>p</i> < 0.05). Meanwhile, AFB<sub>1</sub> exposure increased serum diamine oxidase activity and reduced the mRNA abundance of sodium-glucose cotransporter 1, solute carrier family 7 member 1 and zonula occluden-1 in the jejunal mucosa (<i>p</i> < 0.05). Furthermore, AFB<sub>1</sub> exposure decreased superoxide dismutase activity (<i>p</i> < 0.05) and increased 8-hydroxy-2′-deoxyguanosine content (<i>p</i> < 0.10) in jejunal mucosa. AFB<sub>1</sub> exposure also increased tumor necrosis factor-α, interleukin-1β and transforming growth factor-β mRNA abundance in jejunal mucosa and upregulated <i>Escherichia coli</i> population in colon (<i>p</i> < 0.05). The data indicated that chronic exposure to low levels of dietary AFB<sub>1</sub> suppressed growth performance, reduced the apparent total tract digestibility and damaged intestinal barrier integrity in pigs, which could be associated with the decreased intestinal antioxidant capacity and the increased pro-inflammatory cytokine production.https://www.mdpi.com/2076-2615/11/2/336aflatoxin B<sub>1</sub>growth performanceapparent total tract digestibilityintestinal healthpigs |
| spellingShingle | Junning Pu Qinghui Yuan Hui Yan Gang Tian Daiwen Chen Jun He Ping Zheng Jie Yu Xiangbing Mao Zhiqing Huang Junqiu Luo Yuheng Luo Bing Yu Effects of Chronic Exposure to Low Levels of Dietary Aflatoxin B<sub>1</sub> on Growth Performance, Apparent Total Tract Digestibility and Intestinal Health in Pigs Animals aflatoxin B<sub>1</sub> growth performance apparent total tract digestibility intestinal health pigs |
| title | Effects of Chronic Exposure to Low Levels of Dietary Aflatoxin B<sub>1</sub> on Growth Performance, Apparent Total Tract Digestibility and Intestinal Health in Pigs |
| title_full | Effects of Chronic Exposure to Low Levels of Dietary Aflatoxin B<sub>1</sub> on Growth Performance, Apparent Total Tract Digestibility and Intestinal Health in Pigs |
| title_fullStr | Effects of Chronic Exposure to Low Levels of Dietary Aflatoxin B<sub>1</sub> on Growth Performance, Apparent Total Tract Digestibility and Intestinal Health in Pigs |
| title_full_unstemmed | Effects of Chronic Exposure to Low Levels of Dietary Aflatoxin B<sub>1</sub> on Growth Performance, Apparent Total Tract Digestibility and Intestinal Health in Pigs |
| title_short | Effects of Chronic Exposure to Low Levels of Dietary Aflatoxin B<sub>1</sub> on Growth Performance, Apparent Total Tract Digestibility and Intestinal Health in Pigs |
| title_sort | effects of chronic exposure to low levels of dietary aflatoxin b sub 1 sub on growth performance apparent total tract digestibility and intestinal health in pigs |
| topic | aflatoxin B<sub>1</sub> growth performance apparent total tract digestibility intestinal health pigs |
| url | https://www.mdpi.com/2076-2615/11/2/336 |
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