Chondroitinase ABC Administration in Locomotion Recovery After Spinal Cord Injury: A Systematic Review and Meta-analysis
Introduction: The present systematic review and meta-analysis aims to conduct a comprehensive and complete search of electronic resources to investigate the role of administrating Chondroitinase ABC (ChABC) in improving complications following Spinal Cord Injuries (SCI). Methods: MEDLINE, Embase, Sc...
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| Format: | Article |
| Language: | English |
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Iran University of Medical Sciences
2022-09-01
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| Series: | Basic and Clinical Neuroscience |
| Subjects: | |
| Online Access: | http://bcn.iums.ac.ir/article-1-2074-en.html |
| _version_ | 1797285709048971264 |
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| author | Mahmoud Yousefifard Atousa Janzadeh Kosar Mohamed Ali Mohammad Hossein Vazirizadeh-Mahabadi Arash Sarveazad Arian Madani Neishaboori Mostafa Hosseini |
| author_facet | Mahmoud Yousefifard Atousa Janzadeh Kosar Mohamed Ali Mohammad Hossein Vazirizadeh-Mahabadi Arash Sarveazad Arian Madani Neishaboori Mostafa Hosseini |
| author_sort | Mahmoud Yousefifard |
| collection | DOAJ |
| description | Introduction: The present systematic review and meta-analysis aims to conduct a comprehensive and complete search of electronic resources to investigate the role of administrating Chondroitinase ABC (ChABC) in improving complications following Spinal Cord Injuries (SCI).
Methods: MEDLINE, Embase, Scopus, and Web of Sciences databases were searched until the end of 2019. Two independent reviewers assessed the studies conducted on rats and mice and summarized the data. Using the STATA 14.0 software, the findings were reported as pooled standardized mean differences (SMD) with 95% confidence intervals (CI).
Results: A total of 34 preclinical studies were included. ChABC administration improves locomotion recovery after SCI (SMD=0.90; 95% CI: 0.61 to 1.20; P<0.001). The subgroup analysis showed that the differences in the SCI model (P=0.732), the severity of the injury (P=0.821), the number of ChABC administrations (P=0.092), the blinding status (P=0.294), the use of different locomotor score (P=0.567), and the follow-up duration (P=0.750) have no effect on the efficacy of ChABC treatment.
Conclusion: The findings of the present study showed that prescribing ChABC has a moderate effect in improving locomotion after SCI in mice and rats. However, this moderate effect introduces ChABC as adjuvant therapy and not as primary therapy. |
| first_indexed | 2024-03-07T18:07:10Z |
| format | Article |
| id | doaj.art-0c034718940a4015a76282c21e05dd71 |
| institution | Directory Open Access Journal |
| issn | 2008-126X 2228-7442 |
| language | English |
| last_indexed | 2024-03-07T18:07:10Z |
| publishDate | 2022-09-01 |
| publisher | Iran University of Medical Sciences |
| record_format | Article |
| series | Basic and Clinical Neuroscience |
| spelling | doaj.art-0c034718940a4015a76282c21e05dd712024-03-02T08:32:29ZengIran University of Medical SciencesBasic and Clinical Neuroscience2008-126X2228-74422022-09-01135609624Chondroitinase ABC Administration in Locomotion Recovery After Spinal Cord Injury: A Systematic Review and Meta-analysisMahmoud Yousefifard0Atousa Janzadeh1Kosar Mohamed Ali2Mohammad Hossein Vazirizadeh-Mahabadi3Arash Sarveazad4Arian Madani Neishaboori5Mostafa Hosseini6 Department of Physiology, Researcher at Physiology Research Center, School of Medicine, Iran University of Medical Sciences, Tehran, Iran. Radiation Biology Research Center, Iran University of Medical Sciences, Tehran, Iran. Department of Respiratory Medicine, School of Medicine, University of Sulaimani, Sulaimani, Iraq. Researcher at Student Research Committee, School of Medicine, Iran University of Medical Sciences, Tehran, Iran. Colorectal Research Center, Researcher at Nursing Care Research Center, Iran University of Medical Sciences, Tehran, Iran. Researcher at Physiology Research Centre, School of Medicine, Iran University of Medical Sciences, Tehran, Iran. Department of Epidemiology and Biostatistics School of Public Health, Tehran University of Medical Sciences, Tehran, Iran. Introduction: The present systematic review and meta-analysis aims to conduct a comprehensive and complete search of electronic resources to investigate the role of administrating Chondroitinase ABC (ChABC) in improving complications following Spinal Cord Injuries (SCI). Methods: MEDLINE, Embase, Scopus, and Web of Sciences databases were searched until the end of 2019. Two independent reviewers assessed the studies conducted on rats and mice and summarized the data. Using the STATA 14.0 software, the findings were reported as pooled standardized mean differences (SMD) with 95% confidence intervals (CI). Results: A total of 34 preclinical studies were included. ChABC administration improves locomotion recovery after SCI (SMD=0.90; 95% CI: 0.61 to 1.20; P<0.001). The subgroup analysis showed that the differences in the SCI model (P=0.732), the severity of the injury (P=0.821), the number of ChABC administrations (P=0.092), the blinding status (P=0.294), the use of different locomotor score (P=0.567), and the follow-up duration (P=0.750) have no effect on the efficacy of ChABC treatment. Conclusion: The findings of the present study showed that prescribing ChABC has a moderate effect in improving locomotion after SCI in mice and rats. However, this moderate effect introduces ChABC as adjuvant therapy and not as primary therapy.http://bcn.iums.ac.ir/article-1-2074-en.htmlspinal cord injurieschondroitinase abcanimallocomotion |
| spellingShingle | Mahmoud Yousefifard Atousa Janzadeh Kosar Mohamed Ali Mohammad Hossein Vazirizadeh-Mahabadi Arash Sarveazad Arian Madani Neishaboori Mostafa Hosseini Chondroitinase ABC Administration in Locomotion Recovery After Spinal Cord Injury: A Systematic Review and Meta-analysis Basic and Clinical Neuroscience spinal cord injuries chondroitinase abc animal locomotion |
| title | Chondroitinase ABC Administration in Locomotion Recovery After Spinal Cord Injury: A Systematic Review and Meta-analysis |
| title_full | Chondroitinase ABC Administration in Locomotion Recovery After Spinal Cord Injury: A Systematic Review and Meta-analysis |
| title_fullStr | Chondroitinase ABC Administration in Locomotion Recovery After Spinal Cord Injury: A Systematic Review and Meta-analysis |
| title_full_unstemmed | Chondroitinase ABC Administration in Locomotion Recovery After Spinal Cord Injury: A Systematic Review and Meta-analysis |
| title_short | Chondroitinase ABC Administration in Locomotion Recovery After Spinal Cord Injury: A Systematic Review and Meta-analysis |
| title_sort | chondroitinase abc administration in locomotion recovery after spinal cord injury a systematic review and meta analysis |
| topic | spinal cord injuries chondroitinase abc animal locomotion |
| url | http://bcn.iums.ac.ir/article-1-2074-en.html |
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