Altered dynamic functional connectivity in the primary visual cortex in patients with primary angle-closure glaucoma
PurposeGlaucoma is the main blindness-causing disease in the world. Previous neuroimaging studies demonstrated that glaucoma not only causes the loss of optic ganglion cells but also leads to the abnormal function of the optic nerve pathway and the visual cortex. However, previous studies also repor...
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| Format: | Article |
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Frontiers Media S.A.
2023-02-01
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| Series: | Frontiers in Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnins.2023.1131247/full |
| _version_ | 1828045173259501568 |
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| author | Dong-Jin Li Bing-Lin Huang Yuan Peng Ling-Yan Liang Hui Liu |
| author_facet | Dong-Jin Li Bing-Lin Huang Yuan Peng Ling-Yan Liang Hui Liu |
| author_sort | Dong-Jin Li |
| collection | DOAJ |
| description | PurposeGlaucoma is the main blindness-causing disease in the world. Previous neuroimaging studies demonstrated that glaucoma not only causes the loss of optic ganglion cells but also leads to the abnormal function of the optic nerve pathway and the visual cortex. However, previous studies also reported that patients with glaucoma have dysfunction in the visual cortex in a static state. Whether or not patients with primary angle-closure glaucoma (PACG) were accompanied by dynamic functional connectivity (FC) changes in the primary visual cortex (V1) remains unknown.MethodsA total of 34 patients with PACG (23 men and 11 women) and 34 well-matched healthy controls (HCs) were enrolled in the study. The dynamic functional connectivity (dFC) with the sliding window method was applied to investigate the dynamic functional connectivity changes in the V1.ResultsCompared with HCs, patients with PACG showed increased dFC values between left V1 and bilateral calcarine (CAL). Meanwhile, patients with PACG showed increased dFC values between right V1 and bilateral CAL.ConclusionOur study demonstrated that patients with PACG showed increased dFC within the visual network, which might indicate the increased variability FC in the V1 in patients with PACG. |
| first_indexed | 2024-04-10T18:06:44Z |
| format | Article |
| id | doaj.art-0c0500cee5084445a85e62c0f0831c71 |
| institution | Directory Open Access Journal |
| issn | 1662-453X |
| language | English |
| last_indexed | 2024-04-10T18:06:44Z |
| publishDate | 2023-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroscience |
| spelling | doaj.art-0c0500cee5084445a85e62c0f0831c712023-02-02T12:42:25ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2023-02-011710.3389/fnins.2023.11312471131247Altered dynamic functional connectivity in the primary visual cortex in patients with primary angle-closure glaucomaDong-Jin Li0Bing-Lin Huang1Yuan Peng2Ling-Yan Liang3Hui Liu4Health Management Center, The First People’s Hospital of Jiujiang City, Jiujiang, Jiangxi, ChinaCollege of Clinical Medicine, Jiangxi University of Traditional Chinese Medicine, Nanchang, Jiangxi, ChinaDepartment of Ophthalmology, Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine, Nanchang, Jiangxi, ChinaCollege of Graduate, Jiangxi University of Traditional Chinese Medicine, Nanchang, Jiangxi, ChinaDepartment of Ophthalmology, Jiangxi Provincial People’s Hospital, Nanchang, Jiangxi, ChinaPurposeGlaucoma is the main blindness-causing disease in the world. Previous neuroimaging studies demonstrated that glaucoma not only causes the loss of optic ganglion cells but also leads to the abnormal function of the optic nerve pathway and the visual cortex. However, previous studies also reported that patients with glaucoma have dysfunction in the visual cortex in a static state. Whether or not patients with primary angle-closure glaucoma (PACG) were accompanied by dynamic functional connectivity (FC) changes in the primary visual cortex (V1) remains unknown.MethodsA total of 34 patients with PACG (23 men and 11 women) and 34 well-matched healthy controls (HCs) were enrolled in the study. The dynamic functional connectivity (dFC) with the sliding window method was applied to investigate the dynamic functional connectivity changes in the V1.ResultsCompared with HCs, patients with PACG showed increased dFC values between left V1 and bilateral calcarine (CAL). Meanwhile, patients with PACG showed increased dFC values between right V1 and bilateral CAL.ConclusionOur study demonstrated that patients with PACG showed increased dFC within the visual network, which might indicate the increased variability FC in the V1 in patients with PACG.https://www.frontiersin.org/articles/10.3389/fnins.2023.1131247/fulldynamic functional connectivityfunctional magnetic resonance imagingprimary angle-closure glaucomaprimary visual cortexmachine learning |
| spellingShingle | Dong-Jin Li Bing-Lin Huang Yuan Peng Ling-Yan Liang Hui Liu Altered dynamic functional connectivity in the primary visual cortex in patients with primary angle-closure glaucoma Frontiers in Neuroscience dynamic functional connectivity functional magnetic resonance imaging primary angle-closure glaucoma primary visual cortex machine learning |
| title | Altered dynamic functional connectivity in the primary visual cortex in patients with primary angle-closure glaucoma |
| title_full | Altered dynamic functional connectivity in the primary visual cortex in patients with primary angle-closure glaucoma |
| title_fullStr | Altered dynamic functional connectivity in the primary visual cortex in patients with primary angle-closure glaucoma |
| title_full_unstemmed | Altered dynamic functional connectivity in the primary visual cortex in patients with primary angle-closure glaucoma |
| title_short | Altered dynamic functional connectivity in the primary visual cortex in patients with primary angle-closure glaucoma |
| title_sort | altered dynamic functional connectivity in the primary visual cortex in patients with primary angle closure glaucoma |
| topic | dynamic functional connectivity functional magnetic resonance imaging primary angle-closure glaucoma primary visual cortex machine learning |
| url | https://www.frontiersin.org/articles/10.3389/fnins.2023.1131247/full |
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