A bacterial effector protein promotes nuclear translocation of Stat3 to induce IL-10

A bacterial effector protein promotes nuclear translocation of Stat3 to induce IL-10

The multifunctional Yersinia effector YopM inhibits effector triggered immunity and increases production of the anti-inflammatory cytokine Interleukin-10 (IL-10) to suppress the host immune response. Previously it was shown that YopM induces IL-10 gene expression by elevating phosphorylation of the...

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Bibliographic Details
Main Authors: Laura Berneking, Indra Bekere, Sören Rob, Marie Schnapp, Jiabin Huang, Klaus Ruckdeschel, Martin Aepfelbacher
Format: Article
Language:English
Published: Elsevier 2023-12-01
Series:European Journal of Cell Biology
Subjects:
Yersinia
JAK-STAT signaling
Stat3
IL-10 signaling
Online Access:http://www.sciencedirect.com/science/article/pii/S0171933523000791

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