An investigation of acute effects at various doses of malathion on glucose homeostasis and insulin resistance in rat liver, pancreas and serum
Objective. This study investigates acute effects of various doses of Malathion on glucose homeostasis and insulin resistance in rat. Methods. Rats were randomly divided into four groups of 6 animals each. Corn oil was given orally to Group 1. Group 2, Group 3, and Group 4 received malathion dissolv...
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| Format: | Article |
| Language: | English |
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Ion Motofei, Carol Davila University
2020-04-01
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| Series: | Journal of Mind and Medical Sciences |
| Subjects: | |
| Online Access: | https://scholar.valpo.edu/cgi/viewcontent.cgi?article=1226&context=jmms |
| _version_ | 1818851469294567424 |
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| author | Murat Ekremoğlu Çınar Severcan Özge Tuğce Pasaoğlu Bayram Şen Hatice Pasaoğlu |
| author_facet | Murat Ekremoğlu Çınar Severcan Özge Tuğce Pasaoğlu Bayram Şen Hatice Pasaoğlu |
| author_sort | Murat Ekremoğlu |
| collection | DOAJ |
| description | Objective. This study investigates acute effects of various doses of Malathion on glucose homeostasis and insulin resistance in rat.
Methods. Rats were randomly divided into four groups of 6 animals each. Corn oil was given orally to Group 1. Group 2, Group 3, and Group 4 received malathion dissolved in corn oil via oral administration at the doses of 100, 200 and 400 mg/kg, respectively. 24 hours later the rats were sacrificed.
Results. Acute administration of Malathion led to a decrease in serum butryl cholinesterase (BChE) levels at all doses tested. It also caused a significant increase in serum advanced glycation end products (AGEs), insulin, and TNF-α levels at all doses. Moreover, Malathion administration raised the liver ALT, AST and LDH, TNF-α, and glycogen levels in a dose dependent manner. It also led to a remarkable increase in pancreatic insulin levels at all doses.
Conclusions. Acute administrations of Malathion affect glucose homeostasis in a dose dependent manner through its effects on the liver, serum, and pancreas. |
| first_indexed | 2024-12-19T07:05:31Z |
| format | Article |
| id | doaj.art-0c061f6298e74a3ebcc16e489ca7b7d7 |
| institution | Directory Open Access Journal |
| issn | 2392-7674 2392-7674 |
| language | English |
| last_indexed | 2024-12-19T07:05:31Z |
| publishDate | 2020-04-01 |
| publisher | Ion Motofei, Carol Davila University |
| record_format | Article |
| series | Journal of Mind and Medical Sciences |
| spelling | doaj.art-0c061f6298e74a3ebcc16e489ca7b7d72022-12-21T20:31:17ZengIon Motofei, Carol Davila UniversityJournal of Mind and Medical Sciences2392-76742392-76742020-04-0171859310.22543/7674.71.P8593An investigation of acute effects at various doses of malathion on glucose homeostasis and insulin resistance in rat liver, pancreas and serumMurat Ekremoğlu0Çınar Severcan1Özge Tuğce Pasaoğlu2Bayram Şen3Hatice Pasaoğlu4ALTINBAŞ UNIVERSITY, FACULTY OF MEDICINE, DEPARTMENT OF BIOCHEMISTRY KARTALTEPE AV. İNCIRLI 34145 STR. BAKIRKÖY/İSTANBUL/ TURKEYZONGULDAK BULENT ECEVIT UNIVERSITY, FACULTY OF PHARMACY, DEPARTMENT OF BIOCHEMISTRY, ZONGULDAK, TURKEY GAZI UNIVERSITY, DEPARTMENT OF MEDICAL LABORATORY, COLLEGE OF HEALTH CARE SERVICES, ANKARA, TURKEY. GAZI UNIVERSITY, FACULTY OF MEDICINE, DEPARTMENT OF MEDICAL BIOCHEMISTRY, ANKARA, TURKEY.GAZI UNIVERSITY, FACULTY OF MEDICINE, DEPARTMENT OF MEDICAL BIOCHEMISTRY, ANKARA, TURKEY.Objective. This study investigates acute effects of various doses of Malathion on glucose homeostasis and insulin resistance in rat. Methods. Rats were randomly divided into four groups of 6 animals each. Corn oil was given orally to Group 1. Group 2, Group 3, and Group 4 received malathion dissolved in corn oil via oral administration at the doses of 100, 200 and 400 mg/kg, respectively. 24 hours later the rats were sacrificed. Results. Acute administration of Malathion led to a decrease in serum butryl cholinesterase (BChE) levels at all doses tested. It also caused a significant increase in serum advanced glycation end products (AGEs), insulin, and TNF-α levels at all doses. Moreover, Malathion administration raised the liver ALT, AST and LDH, TNF-α, and glycogen levels in a dose dependent manner. It also led to a remarkable increase in pancreatic insulin levels at all doses. Conclusions. Acute administrations of Malathion affect glucose homeostasis in a dose dependent manner through its effects on the liver, serum, and pancreas.https://scholar.valpo.edu/cgi/viewcontent.cgi?article=1226&context=jmmsmalathionglucose homeostasisinsulin resistancerat liverpancreasserum |
| spellingShingle | Murat Ekremoğlu Çınar Severcan Özge Tuğce Pasaoğlu Bayram Şen Hatice Pasaoğlu An investigation of acute effects at various doses of malathion on glucose homeostasis and insulin resistance in rat liver, pancreas and serum Journal of Mind and Medical Sciences malathion glucose homeostasis insulin resistance rat liver pancreas serum |
| title | An investigation of acute effects at various doses of malathion on glucose homeostasis and insulin resistance in rat liver, pancreas and serum |
| title_full | An investigation of acute effects at various doses of malathion on glucose homeostasis and insulin resistance in rat liver, pancreas and serum |
| title_fullStr | An investigation of acute effects at various doses of malathion on glucose homeostasis and insulin resistance in rat liver, pancreas and serum |
| title_full_unstemmed | An investigation of acute effects at various doses of malathion on glucose homeostasis and insulin resistance in rat liver, pancreas and serum |
| title_short | An investigation of acute effects at various doses of malathion on glucose homeostasis and insulin resistance in rat liver, pancreas and serum |
| title_sort | investigation of acute effects at various doses of malathion on glucose homeostasis and insulin resistance in rat liver pancreas and serum |
| topic | malathion glucose homeostasis insulin resistance rat liver pancreas serum |
| url | https://scholar.valpo.edu/cgi/viewcontent.cgi?article=1226&context=jmms |
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