Breath Analysis: A Promising Tool for Disease Diagnosis—The Role of Sensors
Early-stage disease diagnosis is of particular importance for effective patient identification as well as their treatment. Lack of patient compliance for the existing diagnostic methods, however, limits prompt diagnosis, rendering the development of non-invasive diagnostic tools mandatory. One of th...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-02-01
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| Series: | Sensors |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1424-8220/22/3/1238 |
| _version_ | 1797484519797817344 |
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| author | Maria Kaloumenou Evangelos Skotadis Nefeli Lagopati Efstathios Efstathopoulos Dimitris Tsoukalas |
| author_facet | Maria Kaloumenou Evangelos Skotadis Nefeli Lagopati Efstathios Efstathopoulos Dimitris Tsoukalas |
| author_sort | Maria Kaloumenou |
| collection | DOAJ |
| description | Early-stage disease diagnosis is of particular importance for effective patient identification as well as their treatment. Lack of patient compliance for the existing diagnostic methods, however, limits prompt diagnosis, rendering the development of non-invasive diagnostic tools mandatory. One of the most promising non-invasive diagnostic methods that has also attracted great research interest during the last years is breath analysis; the method detects gas-analytes such as exhaled volatile organic compounds (VOCs) and inorganic gases that are considered to be important biomarkers for various disease-types. The diagnostic ability of gas-pattern detection using analytical techniques and especially sensors has been widely discussed in the literature; however, the incorporation of novel nanomaterials in sensor-development has also proved to enhance sensor performance, for both selective and cross-reactive applications. The aim of the first part of this review is to provide an up-to-date overview of the main categories of sensors studied for disease diagnosis applications via the detection of exhaled gas-analytes and to highlight the role of nanomaterials. The second and most novel part of this review concentrates on the remarkable applicability of breath analysis in differential diagnosis, phenotyping, and the staging of several disease-types, which are currently amongst the most pressing challenges in the field. |
| first_indexed | 2024-03-09T23:06:32Z |
| format | Article |
| id | doaj.art-0c0846e0184f4d82bc6b839c676de70b |
| institution | Directory Open Access Journal |
| issn | 1424-8220 |
| language | English |
| last_indexed | 2024-03-09T23:06:32Z |
| publishDate | 2022-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Sensors |
| spelling | doaj.art-0c0846e0184f4d82bc6b839c676de70b2023-11-23T17:52:45ZengMDPI AGSensors1424-82202022-02-01223123810.3390/s22031238Breath Analysis: A Promising Tool for Disease Diagnosis—The Role of SensorsMaria Kaloumenou0Evangelos Skotadis1Nefeli Lagopati2Efstathios Efstathopoulos3Dimitris Tsoukalas4Department of Applied Physics, National Technical University of Athens, 15780 Athens, GreeceDepartment of Applied Physics, National Technical University of Athens, 15780 Athens, GreeceMedical School, National and Kapodistrian University of Athens, 75, Mikras Asias Str., Goudi, 11527 Athens, GreeceMedical School, National and Kapodistrian University of Athens, 75, Mikras Asias Str., Goudi, 11527 Athens, GreeceDepartment of Applied Physics, National Technical University of Athens, 15780 Athens, GreeceEarly-stage disease diagnosis is of particular importance for effective patient identification as well as their treatment. Lack of patient compliance for the existing diagnostic methods, however, limits prompt diagnosis, rendering the development of non-invasive diagnostic tools mandatory. One of the most promising non-invasive diagnostic methods that has also attracted great research interest during the last years is breath analysis; the method detects gas-analytes such as exhaled volatile organic compounds (VOCs) and inorganic gases that are considered to be important biomarkers for various disease-types. The diagnostic ability of gas-pattern detection using analytical techniques and especially sensors has been widely discussed in the literature; however, the incorporation of novel nanomaterials in sensor-development has also proved to enhance sensor performance, for both selective and cross-reactive applications. The aim of the first part of this review is to provide an up-to-date overview of the main categories of sensors studied for disease diagnosis applications via the detection of exhaled gas-analytes and to highlight the role of nanomaterials. The second and most novel part of this review concentrates on the remarkable applicability of breath analysis in differential diagnosis, phenotyping, and the staging of several disease-types, which are currently amongst the most pressing challenges in the field.https://www.mdpi.com/1424-8220/22/3/1238breath analysisvolatile organic compoundssensorsnanomaterialsdifferential diagnosis |
| spellingShingle | Maria Kaloumenou Evangelos Skotadis Nefeli Lagopati Efstathios Efstathopoulos Dimitris Tsoukalas Breath Analysis: A Promising Tool for Disease Diagnosis—The Role of Sensors Sensors breath analysis volatile organic compounds sensors nanomaterials differential diagnosis |
| title | Breath Analysis: A Promising Tool for Disease Diagnosis—The Role of Sensors |
| title_full | Breath Analysis: A Promising Tool for Disease Diagnosis—The Role of Sensors |
| title_fullStr | Breath Analysis: A Promising Tool for Disease Diagnosis—The Role of Sensors |
| title_full_unstemmed | Breath Analysis: A Promising Tool for Disease Diagnosis—The Role of Sensors |
| title_short | Breath Analysis: A Promising Tool for Disease Diagnosis—The Role of Sensors |
| title_sort | breath analysis a promising tool for disease diagnosis the role of sensors |
| topic | breath analysis volatile organic compounds sensors nanomaterials differential diagnosis |
| url | https://www.mdpi.com/1424-8220/22/3/1238 |
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