Protein disulfide isomerase cleaves allosteric disulfides in histidine-rich glycoprotein to regulate thrombosis

Protein disulfide isomerase cleaves allosteric disulfides in histidine-rich glycoprotein to regulate thrombosis

Abstract The essence of difference between hemostasis and thrombosis is that the clotting reaction is a highly fine-tuned process. Vascular protein disulfide isomerase (PDI) represents a critical mechanism regulating the functions of hemostatic proteins. Herein we show that histidine-rich glycoprote...

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Bibliographic Details
Main Authors: Keyu Lv, Shuai Chen, Xulin Xu, Joyce Chiu, Haoqing J. Wang, Yunyun Han, Xiaodan Yang, Sheryl R. Bowley, Hao Wang, Zhaoming Tang, Ning Tang, Aizhen Yang, Shuofei Yang, Jinyu Wang, Si Jin, Yi Wu, Alvin H. Schmaier, Lining A. Ju, Philip J. Hogg, Chao Fang
Format: Article
Language:English
Published: Nature Portfolio 2024-04-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-47493-0

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