Fundamental concepts of radiopharmaceuticals quality controls
Quality control (QC) procedures should always be performed following radiopharmaceutical preparation and prior to patient administration. The main aim of QC is to ensure optimal radiopharmaceutical product properties except for some short half-life tracers such as some positron emission tomography (...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Mazandaran University of Medical Sciences
2018-12-01
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| Series: | Pharmaceutical and Biomedical Research |
| Subjects: | |
| Online Access: | http://pbr.mazums.ac.ir/article-1-198-en.html |
| _version_ | 1819069929100410880 |
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| author | Sajjad Molavipordanjani Seyed Jalal Hosseinimehr |
| author_facet | Sajjad Molavipordanjani Seyed Jalal Hosseinimehr |
| author_sort | Sajjad Molavipordanjani |
| collection | DOAJ |
| description | Quality control (QC) procedures should always be performed following radiopharmaceutical preparation and prior to patient administration. The main aim of QC is to ensure optimal radiopharmaceutical product properties except for some short half-life tracers such as some positron emission tomography (PET) imaging probs. by dispensing a radiopharmaceutical of the highest quality the risk of having to repeat a nuclear medicine study due to poorly performing radiopharmaceuticals will be reduced. The existence of radiochemical impurity or impurities in radiopharmaceutical cause unnecessary radiation burden to the patient or undesirable high background without adding to the diagnostic information or improving treatment. Therefore, radiopharmaceuticals quality control is crucial and involves two different aspects including pharmaceutical parameters (such as sterility, bacterial endotoxins/ pyrogens, bioaffinity and biodistribution studies) and radioactive parameters (such as radionuclide and radiochemical purity) and chemical impurity which will be focused on here. |
| first_indexed | 2024-12-21T16:57:51Z |
| format | Article |
| id | doaj.art-0c0877d87f1f4f1db5b4845747f50a3d |
| institution | Directory Open Access Journal |
| issn | 2423-4486 2423-4494 |
| language | English |
| last_indexed | 2024-12-21T16:57:51Z |
| publishDate | 2018-12-01 |
| publisher | Mazandaran University of Medical Sciences |
| record_format | Article |
| series | Pharmaceutical and Biomedical Research |
| spelling | doaj.art-0c0877d87f1f4f1db5b4845747f50a3d2022-12-21T18:56:43ZengMazandaran University of Medical SciencesPharmaceutical and Biomedical Research2423-44862423-44942018-12-014318Fundamental concepts of radiopharmaceuticals quality controlsSajjad Molavipordanjani0Seyed Jalal Hosseinimehr1 Department of Radiopharmacy, Faculty of Pharmacy, Mazandaran University of Medical, Sciences, Sari, Iran Department of Radiopharmacy, Faculty of Pharmacy, Mazandaran University of Medical, Sciences, Sari, Iran Quality control (QC) procedures should always be performed following radiopharmaceutical preparation and prior to patient administration. The main aim of QC is to ensure optimal radiopharmaceutical product properties except for some short half-life tracers such as some positron emission tomography (PET) imaging probs. by dispensing a radiopharmaceutical of the highest quality the risk of having to repeat a nuclear medicine study due to poorly performing radiopharmaceuticals will be reduced. The existence of radiochemical impurity or impurities in radiopharmaceutical cause unnecessary radiation burden to the patient or undesirable high background without adding to the diagnostic information or improving treatment. Therefore, radiopharmaceuticals quality control is crucial and involves two different aspects including pharmaceutical parameters (such as sterility, bacterial endotoxins/ pyrogens, bioaffinity and biodistribution studies) and radioactive parameters (such as radionuclide and radiochemical purity) and chemical impurity which will be focused on here.http://pbr.mazums.ac.ir/article-1-198-en.htmlradiopharmaceuticalquality controlradiochemicalradionuclidepurity |
| spellingShingle | Sajjad Molavipordanjani Seyed Jalal Hosseinimehr Fundamental concepts of radiopharmaceuticals quality controls Pharmaceutical and Biomedical Research radiopharmaceutical quality control radiochemical radionuclide purity |
| title | Fundamental concepts of radiopharmaceuticals quality controls |
| title_full | Fundamental concepts of radiopharmaceuticals quality controls |
| title_fullStr | Fundamental concepts of radiopharmaceuticals quality controls |
| title_full_unstemmed | Fundamental concepts of radiopharmaceuticals quality controls |
| title_short | Fundamental concepts of radiopharmaceuticals quality controls |
| title_sort | fundamental concepts of radiopharmaceuticals quality controls |
| topic | radiopharmaceutical quality control radiochemical radionuclide purity |
| url | http://pbr.mazums.ac.ir/article-1-198-en.html |
| work_keys_str_mv | AT sajjadmolavipordanjani fundamentalconceptsofradiopharmaceuticalsqualitycontrols AT seyedjalalhosseinimehr fundamentalconceptsofradiopharmaceuticalsqualitycontrols |