New insights into vascular aging: Emerging role of mitochondria function
Vascular aging, a major risk factor for cardiovascular disease, contributes to morbidity and mortality in older people. Mitochondria play an important role in vascular aging. In endothelial and smooth muscle cells, multiple changes in the mitochondrial structure and function contribute to aging, inc...
Main Authors: | , , , , , , , |
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Format: | Article |
Language: | English |
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Elsevier
2022-12-01
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Series: | Biomedicine & Pharmacotherapy |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S0753332222013439 |
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author | Yu-juan Li Xiao Jin Dan Li Jing Lu Xiao-nan Zhang Sheng-jie Yang Yi-xi Zhao Min Wu |
author_facet | Yu-juan Li Xiao Jin Dan Li Jing Lu Xiao-nan Zhang Sheng-jie Yang Yi-xi Zhao Min Wu |
author_sort | Yu-juan Li |
collection | DOAJ |
description | Vascular aging, a major risk factor for cardiovascular disease, contributes to morbidity and mortality in older people. Mitochondria play an important role in vascular aging. In endothelial and smooth muscle cells, multiple changes in the mitochondrial structure and function contribute to aging, including the effects of mitochondrial oxidative stress, mitochondrial DNA mutations, mitochondrial dynamics, and mitophagy. Mitochondrial dysfunction also contributes to other age-related molecular and cellular mechanisms, such as crosstalk with telomeres, senescence-associated secretory phenotypes, and low-grade inflammation. Thus, enhancing mitochondrial biogenesis, reducing oxidative stress, recovering dynamics, and mitophagy have been suggested as effective interventions to delay vascular aging and age-related cardiovascular diseases. Furthermore, accumulating evidence has shown that commonly used herbs and their natural compounds have great potential to improve mitochondrial function during vascular aging. Herein, we review the cellular and molecular mechanisms of mitochondrial effects on vascular aging, emphasizing the efficacy of natural compounds in the treatment of vascular aging by improving mitochondrial structure and function. We aim to provide new insights into delaying vascular aging and preventing cardiovascular diseases. |
first_indexed | 2024-04-13T09:26:12Z |
format | Article |
id | doaj.art-0c09046b38ba4b7d83d2e4cb79c9b659 |
institution | Directory Open Access Journal |
issn | 0753-3322 |
language | English |
last_indexed | 2024-04-13T09:26:12Z |
publishDate | 2022-12-01 |
publisher | Elsevier |
record_format | Article |
series | Biomedicine & Pharmacotherapy |
spelling | doaj.art-0c09046b38ba4b7d83d2e4cb79c9b6592022-12-22T02:52:25ZengElsevierBiomedicine & Pharmacotherapy0753-33222022-12-01156113954New insights into vascular aging: Emerging role of mitochondria functionYu-juan Li0Xiao Jin1Dan Li2Jing Lu3Xiao-nan Zhang4Sheng-jie Yang5Yi-xi Zhao6Min Wu7Guang’an Men Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, ChinaGuang’an Men Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, ChinaGuang’an Men Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, ChinaGuang’an Men Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China; Beijing University of Chinese Medicine, Beijing 100029, ChinaXiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing 100091, ChinaGuang’an Men Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, ChinaGuang’an Men Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China; Beijing University of Chinese Medicine, Beijing 100029, ChinaGuang’an Men Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China; Corresponding author.Vascular aging, a major risk factor for cardiovascular disease, contributes to morbidity and mortality in older people. Mitochondria play an important role in vascular aging. In endothelial and smooth muscle cells, multiple changes in the mitochondrial structure and function contribute to aging, including the effects of mitochondrial oxidative stress, mitochondrial DNA mutations, mitochondrial dynamics, and mitophagy. Mitochondrial dysfunction also contributes to other age-related molecular and cellular mechanisms, such as crosstalk with telomeres, senescence-associated secretory phenotypes, and low-grade inflammation. Thus, enhancing mitochondrial biogenesis, reducing oxidative stress, recovering dynamics, and mitophagy have been suggested as effective interventions to delay vascular aging and age-related cardiovascular diseases. Furthermore, accumulating evidence has shown that commonly used herbs and their natural compounds have great potential to improve mitochondrial function during vascular aging. Herein, we review the cellular and molecular mechanisms of mitochondrial effects on vascular aging, emphasizing the efficacy of natural compounds in the treatment of vascular aging by improving mitochondrial structure and function. We aim to provide new insights into delaying vascular aging and preventing cardiovascular diseases.http://www.sciencedirect.com/science/article/pii/S0753332222013439Vascular agingMitochondriaEndothelial cellVascular smooth muscle cellNatural compounds |
spellingShingle | Yu-juan Li Xiao Jin Dan Li Jing Lu Xiao-nan Zhang Sheng-jie Yang Yi-xi Zhao Min Wu New insights into vascular aging: Emerging role of mitochondria function Biomedicine & Pharmacotherapy Vascular aging Mitochondria Endothelial cell Vascular smooth muscle cell Natural compounds |
title | New insights into vascular aging: Emerging role of mitochondria function |
title_full | New insights into vascular aging: Emerging role of mitochondria function |
title_fullStr | New insights into vascular aging: Emerging role of mitochondria function |
title_full_unstemmed | New insights into vascular aging: Emerging role of mitochondria function |
title_short | New insights into vascular aging: Emerging role of mitochondria function |
title_sort | new insights into vascular aging emerging role of mitochondria function |
topic | Vascular aging Mitochondria Endothelial cell Vascular smooth muscle cell Natural compounds |
url | http://www.sciencedirect.com/science/article/pii/S0753332222013439 |
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