A Rare Case of Brain Metastasis from dedifferentiated Acinic Cell Carcinoma of Parotid Gland and Review of the Literature
Acinic cell carcinoma (ACC) is a low or intermediate-grade malignant epithelial neoplasm of the salivary glands that generally shows an indolent behavior. Most cases arise in the major salivary glands, especially the parotid gland. ACC is usually known as a low-grade malignant tumor; however, poorly...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Iranian Society of Pathology
2022-01-01
|
| Series: | Iranian Journal of Pathology |
| Subjects: | |
| Online Access: | https://ijp.iranpath.org/article_246813_a3481f4a27226109a1dc05ae43c5c08d.pdf |
| _version_ | 1819110859930075136 |
|---|---|
| author | Elham Mirzaian Shafighe Asgarikarchekani Ashkan Abdoli |
| author_facet | Elham Mirzaian Shafighe Asgarikarchekani Ashkan Abdoli |
| author_sort | Elham Mirzaian |
| collection | DOAJ |
| description | Acinic cell carcinoma (ACC) is a low or intermediate-grade malignant epithelial neoplasm of the salivary glands that generally shows an indolent behavior. Most cases arise in the major salivary glands, especially the parotid gland. ACC is usually known as a low-grade malignant tumor; however, poorly differentiated and high-grade transformed variants have been reported and may have a tendency for late recurrence and metastasis.Our case was a 49-year-old woman with a history of a right parotid rapidly growing mass lesion, which was cytologically diagnosed as monomorphic adenoma on fine-needle aspiration (FNA). Finally, the diagnosis of ACC with dedifferentiated components was reported followed by parotidectomy. After 30 sessions of radiotherapy, she presented with hemifacial paresis. An imaging examination of the brain showed intracranial hemorrhage, and she underwent a craniotomy. We performed histopathological and immunohistochemistry (IHC) examinations and diagnosed metastatic ACC with the dedifferentiated components.Few studies have reported ACC cases with dedifferentiated components and aggressive behavior, and to the best of our knowledge, this is the first published English report from the Persian population. |
| first_indexed | 2024-12-22T03:48:25Z |
| format | Article |
| id | doaj.art-0c0927ede480414ca67054c033097c35 |
| institution | Directory Open Access Journal |
| issn | 1735-5303 2345-3656 |
| language | English |
| last_indexed | 2024-12-22T03:48:25Z |
| publishDate | 2022-01-01 |
| publisher | Iranian Society of Pathology |
| record_format | Article |
| series | Iranian Journal of Pathology |
| spelling | doaj.art-0c0927ede480414ca67054c033097c352022-12-21T18:40:04ZengIranian Society of PathologyIranian Journal of Pathology1735-53032345-36562022-01-011719710310.30699/ijp.2021.530574.2645246813A Rare Case of Brain Metastasis from dedifferentiated Acinic Cell Carcinoma of Parotid Gland and Review of the LiteratureElham Mirzaian0Shafighe Asgarikarchekani1Ashkan Abdoli2Department of Pathology, Shariati Hospital, School of Medicine, Tehran University of Medical Sciences, Tehran, IranDepartment of Pathology, Shariati Hospital, School of Medicine, Tehran University of Medical Sciences, Tehran, IranDepartment of Pathology, Shariati Hospital, School of Medicine, Tehran University of Medical Sciences, Tehran, IranAcinic cell carcinoma (ACC) is a low or intermediate-grade malignant epithelial neoplasm of the salivary glands that generally shows an indolent behavior. Most cases arise in the major salivary glands, especially the parotid gland. ACC is usually known as a low-grade malignant tumor; however, poorly differentiated and high-grade transformed variants have been reported and may have a tendency for late recurrence and metastasis.Our case was a 49-year-old woman with a history of a right parotid rapidly growing mass lesion, which was cytologically diagnosed as monomorphic adenoma on fine-needle aspiration (FNA). Finally, the diagnosis of ACC with dedifferentiated components was reported followed by parotidectomy. After 30 sessions of radiotherapy, she presented with hemifacial paresis. An imaging examination of the brain showed intracranial hemorrhage, and she underwent a craniotomy. We performed histopathological and immunohistochemistry (IHC) examinations and diagnosed metastatic ACC with the dedifferentiated components.Few studies have reported ACC cases with dedifferentiated components and aggressive behavior, and to the best of our knowledge, this is the first published English report from the Persian population.https://ijp.iranpath.org/article_246813_a3481f4a27226109a1dc05ae43c5c08d.pdfacinic cell carcinomadedifferentiationmetastasisneoplasmsalivary gland |
| spellingShingle | Elham Mirzaian Shafighe Asgarikarchekani Ashkan Abdoli A Rare Case of Brain Metastasis from dedifferentiated Acinic Cell Carcinoma of Parotid Gland and Review of the Literature Iranian Journal of Pathology acinic cell carcinoma dedifferentiation metastasis neoplasm salivary gland |
| title | A Rare Case of Brain Metastasis from dedifferentiated Acinic Cell Carcinoma of Parotid Gland and Review of the Literature |
| title_full | A Rare Case of Brain Metastasis from dedifferentiated Acinic Cell Carcinoma of Parotid Gland and Review of the Literature |
| title_fullStr | A Rare Case of Brain Metastasis from dedifferentiated Acinic Cell Carcinoma of Parotid Gland and Review of the Literature |
| title_full_unstemmed | A Rare Case of Brain Metastasis from dedifferentiated Acinic Cell Carcinoma of Parotid Gland and Review of the Literature |
| title_short | A Rare Case of Brain Metastasis from dedifferentiated Acinic Cell Carcinoma of Parotid Gland and Review of the Literature |
| title_sort | rare case of brain metastasis from dedifferentiated acinic cell carcinoma of parotid gland and review of the literature |
| topic | acinic cell carcinoma dedifferentiation metastasis neoplasm salivary gland |
| url | https://ijp.iranpath.org/article_246813_a3481f4a27226109a1dc05ae43c5c08d.pdf |
| work_keys_str_mv | AT elhammirzaian ararecaseofbrainmetastasisfromdedifferentiatedaciniccellcarcinomaofparotidglandandreviewoftheliterature AT shafigheasgarikarchekani ararecaseofbrainmetastasisfromdedifferentiatedaciniccellcarcinomaofparotidglandandreviewoftheliterature AT ashkanabdoli ararecaseofbrainmetastasisfromdedifferentiatedaciniccellcarcinomaofparotidglandandreviewoftheliterature AT elhammirzaian rarecaseofbrainmetastasisfromdedifferentiatedaciniccellcarcinomaofparotidglandandreviewoftheliterature AT shafigheasgarikarchekani rarecaseofbrainmetastasisfromdedifferentiatedaciniccellcarcinomaofparotidglandandreviewoftheliterature AT ashkanabdoli rarecaseofbrainmetastasisfromdedifferentiatedaciniccellcarcinomaofparotidglandandreviewoftheliterature |