Evaluation of the Effect of Oral Isotretinoin on the Level of Serum YKL40 in Acne Vulgaris Patients: A Cross-Sectional Case-Control
Mahmoud Ahmed Ali,1 Moustafa Adam El Taieb,1 Eisa Mohamed Hegazy,2 Hassan M Ibrahim,2 Alshimaa Abbas Mohamed,1 Mohamed Amer Ahmed Abdellatif,1 Nour Mohammed Ahmed,3 Ali Mohamed Younis1 1Dermatology, Venereology, and Andrology Department, Faculty of Medicine, Aswan University, Aswan, Egypt; 2Dermatol...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2023-11-01
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| Series: | Clinical, Cosmetic and Investigational Dermatology |
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| Online Access: | https://www.dovepress.com/evaluation-of-the-effect-of-oral-isotretinoin-on-the-level-of-serum-yk-peer-reviewed-fulltext-article-CCID |
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| author | Ali MA El Taieb MA Hegazy EM Ibrahim HM Mohamed AA Abdellatif MAA Ahmed NM Younis AM |
| author_facet | Ali MA El Taieb MA Hegazy EM Ibrahim HM Mohamed AA Abdellatif MAA Ahmed NM Younis AM |
| author_sort | Ali MA |
| collection | DOAJ |
| description | Mahmoud Ahmed Ali,1 Moustafa Adam El Taieb,1 Eisa Mohamed Hegazy,2 Hassan M Ibrahim,2 Alshimaa Abbas Mohamed,1 Mohamed Amer Ahmed Abdellatif,1 Nour Mohammed Ahmed,3 Ali Mohamed Younis1 1Dermatology, Venereology, and Andrology Department, Faculty of Medicine, Aswan University, Aswan, Egypt; 2Dermatology, Venereology, and Andrology Department, Faculty of Medicine South Valley University, Qena, Egypt; 3Clinical Pathology Department, Faculty of Medicine, Aswan University, Aswan, EgyptCorrespondence: Mahmoud Ahmed Ali, Dermatology, Venereology, and Andrology Department, Faculty of Medicine, Aswan University, Aswan, 81528, Egypt, Tel +201002364902, Email dr.mahmoudali8051@gmail.comBackground: In the entire world, acne vulgaris (AV) is the most prevalent skin condition. Approximately 9.4% of people worldwide have acne vulgaris. This study compared the blood levels of chitinase 3-like protein 1 (YKL-40) in acne vulgaris patients before and after oral isotretinoin therapy.Patients and Methods: The design of the study was cross-sectional case-control. Forty patients with moderate to severe acne vulgaris and twenty healthy participants participated in this study. Using the Global Acne Grading System (GAGS) score, patients with acne vulgaris were evaluated both before and after concluding their treatment. Using the enzyme-linked immunosorbent assay (ELISA), the serum levels of YKL-40 were measured before and after oral isotretinoin therapy in healthy controls and acne patients.Results: Patients with acne vulgaris had considerably greater serum levels of YKL-40 than healthy control subjects (p 0.001) did. After three months of oral isotretinoin medication, the GAGS score and blood levels of YKL-40 in acne vulgaris patients both significantly decreased.Conclusion: The conclusion of this study was that reducing the blood levels of YKL-40 and the GAGS score in patients with acne vulgaris who took oral isotretinoin for three months was a crucial strategy.Keywords: acne vulgaris, YKL-40, isotretinoin, GAGS |
| first_indexed | 2024-03-11T11:43:08Z |
| format | Article |
| id | doaj.art-0c09668ed78f4bc69bc03f03e4b99fee |
| institution | Directory Open Access Journal |
| issn | 1178-7015 |
| language | English |
| last_indexed | 2024-03-11T11:43:08Z |
| publishDate | 2023-11-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Clinical, Cosmetic and Investigational Dermatology |
| spelling | doaj.art-0c09668ed78f4bc69bc03f03e4b99fee2023-11-09T17:11:20ZengDove Medical PressClinical, Cosmetic and Investigational Dermatology1178-70152023-11-01Volume 163241324888037Evaluation of the Effect of Oral Isotretinoin on the Level of Serum YKL40 in Acne Vulgaris Patients: A Cross-Sectional Case-ControlAli MAEl Taieb MAHegazy EMIbrahim HMMohamed AAAbdellatif MAAAhmed NMYounis AMMahmoud Ahmed Ali,1 Moustafa Adam El Taieb,1 Eisa Mohamed Hegazy,2 Hassan M Ibrahim,2 Alshimaa Abbas Mohamed,1 Mohamed Amer Ahmed Abdellatif,1 Nour Mohammed Ahmed,3 Ali Mohamed Younis1 1Dermatology, Venereology, and Andrology Department, Faculty of Medicine, Aswan University, Aswan, Egypt; 2Dermatology, Venereology, and Andrology Department, Faculty of Medicine South Valley University, Qena, Egypt; 3Clinical Pathology Department, Faculty of Medicine, Aswan University, Aswan, EgyptCorrespondence: Mahmoud Ahmed Ali, Dermatology, Venereology, and Andrology Department, Faculty of Medicine, Aswan University, Aswan, 81528, Egypt, Tel +201002364902, Email dr.mahmoudali8051@gmail.comBackground: In the entire world, acne vulgaris (AV) is the most prevalent skin condition. Approximately 9.4% of people worldwide have acne vulgaris. This study compared the blood levels of chitinase 3-like protein 1 (YKL-40) in acne vulgaris patients before and after oral isotretinoin therapy.Patients and Methods: The design of the study was cross-sectional case-control. Forty patients with moderate to severe acne vulgaris and twenty healthy participants participated in this study. Using the Global Acne Grading System (GAGS) score, patients with acne vulgaris were evaluated both before and after concluding their treatment. Using the enzyme-linked immunosorbent assay (ELISA), the serum levels of YKL-40 were measured before and after oral isotretinoin therapy in healthy controls and acne patients.Results: Patients with acne vulgaris had considerably greater serum levels of YKL-40 than healthy control subjects (p 0.001) did. After three months of oral isotretinoin medication, the GAGS score and blood levels of YKL-40 in acne vulgaris patients both significantly decreased.Conclusion: The conclusion of this study was that reducing the blood levels of YKL-40 and the GAGS score in patients with acne vulgaris who took oral isotretinoin for three months was a crucial strategy.Keywords: acne vulgaris, YKL-40, isotretinoin, GAGShttps://www.dovepress.com/evaluation-of-the-effect-of-oral-isotretinoin-on-the-level-of-serum-yk-peer-reviewed-fulltext-article-CCIDacne vulgarisykl-40isotretinoingags |
| spellingShingle | Ali MA El Taieb MA Hegazy EM Ibrahim HM Mohamed AA Abdellatif MAA Ahmed NM Younis AM Evaluation of the Effect of Oral Isotretinoin on the Level of Serum YKL40 in Acne Vulgaris Patients: A Cross-Sectional Case-Control Clinical, Cosmetic and Investigational Dermatology acne vulgaris ykl-40 isotretinoin gags |
| title | Evaluation of the Effect of Oral Isotretinoin on the Level of Serum YKL40 in Acne Vulgaris Patients: A Cross-Sectional Case-Control |
| title_full | Evaluation of the Effect of Oral Isotretinoin on the Level of Serum YKL40 in Acne Vulgaris Patients: A Cross-Sectional Case-Control |
| title_fullStr | Evaluation of the Effect of Oral Isotretinoin on the Level of Serum YKL40 in Acne Vulgaris Patients: A Cross-Sectional Case-Control |
| title_full_unstemmed | Evaluation of the Effect of Oral Isotretinoin on the Level of Serum YKL40 in Acne Vulgaris Patients: A Cross-Sectional Case-Control |
| title_short | Evaluation of the Effect of Oral Isotretinoin on the Level of Serum YKL40 in Acne Vulgaris Patients: A Cross-Sectional Case-Control |
| title_sort | evaluation of the effect of oral isotretinoin on the level of serum ykl40 in acne vulgaris patients a cross sectional case control |
| topic | acne vulgaris ykl-40 isotretinoin gags |
| url | https://www.dovepress.com/evaluation-of-the-effect-of-oral-isotretinoin-on-the-level-of-serum-yk-peer-reviewed-fulltext-article-CCID |
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