Histomorphologic Spectrum in Hyaline Vascular Variant of Castleman Disease
Introduction: Castleman Disease (CD) is a rare lymphoproliferative disorder with heterogenous clinical and pathological features. It is a rare disease with mention in the rare disease data of the orphanet. It can present as unicentric or multicentric disease. Hyaline vascular variant and plasma c...
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JCDR Research and Publications Private Limited
2017-08-01
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| Series: | Journal of Clinical and Diagnostic Research |
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| Online Access: | https://jcdr.net/articles/PDF/10326/29415_CE[Ra]_F(Sh)_PF1(P_RB)_PFA(P_VSU).pdf |
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| author | Chaithra Gowthuvalli Venkataramana Hema Kini Debarshi Saha Sharada Rai Deepa Sowkur Anandarama Adiga Ranjitha Rao Cheryl Sarah Philipose |
| author_facet | Chaithra Gowthuvalli Venkataramana Hema Kini Debarshi Saha Sharada Rai Deepa Sowkur Anandarama Adiga Ranjitha Rao Cheryl Sarah Philipose |
| author_sort | Chaithra Gowthuvalli Venkataramana |
| collection | DOAJ |
| description | Introduction: Castleman Disease (CD) is a rare lymphoproliferative disorder with heterogenous clinical and pathological
features. It is a rare disease with mention in the rare disease
data of the orphanet. It can present as unicentric or multicentric
disease. Hyaline vascular variant and plasma cell variant are the
two pathological subtypes. Hyaline vascular variant accounts
for nearly 80% to 90% of unicentric cases. Hyaline vascular
subtype variant has follicular and stroma rich subtype.
Aim: To study the histomorphologic spectrum of hyaline
vascular variant of CD.
Materials and Methods: Retrospective cross-sectional,
observational study was undertaken from the archival data
between January 2009 and April 2015. Only ten cases of hyaline
vascular CD were identified after studying the histomorphological
characteristics. Both follicular and interfollicular changes were
studied in detail.
Results: The age of presentation ranged from 17 years to 59
years. Seven out of 10 cases were female. Site of presentation
included cervical, inguinal, retroperitoneal, intra-abdominal and
axillary. Six cases showed predominant follicular change. Two
cases were sclerotic subtype. Two cases showed both follicular
and interfollicular changes in equal proportion.
Distribution of follicles throughout the lymphnode was seen
in eight cases. Uniform sized follicles seen in seven out of ten
cases. Small germinal centre with lymphocyte depletion was
one of the uniform features seen in all 10 cases. Numerous
high endothelial vessels were seen in nine cases. Twinning of
germinal centre was seen in two cases. All ten cases showed
concentric rings of small lymphocytes. Lollipop pattern was
relatively rare feature seen in only two cases.
Conclusion: Hyaline vascular variant of CD has considerable
morphologic variation with few consistent features seen in most
of the cases. |
| first_indexed | 2024-12-13T04:17:30Z |
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| issn | 2249-782X 0973-709X |
| language | English |
| last_indexed | 2024-12-13T04:17:30Z |
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| publisher | JCDR Research and Publications Private Limited |
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| series | Journal of Clinical and Diagnostic Research |
| spelling | doaj.art-0c0bf663e8c749ac97607d4e2bb5fb4d2022-12-21T23:59:51ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2017-08-01118EC01EC0410.7860/JCDR/2017/29415.10326Histomorphologic Spectrum in Hyaline Vascular Variant of Castleman DiseaseChaithra Gowthuvalli Venkataramana0Hema Kini1Debarshi Saha2Sharada Rai3Deepa Sowkur Anandarama Adiga4Ranjitha Rao5Cheryl Sarah Philipose6Assistant Professor, Department of Pathology, Kasturba Medical College, Mangaluru, Karnataka, India.Professor, Department of Pathology, Kasturba Medical College, Mangaluru, Karnataka, India.Associate Professor, Department of Pathology, Kasturba Medical College, Mangaluru, Karnataka, India.Associate Professor, Department of Pathology, Kasturba Medical College, Mangaluru, Karnataka, India.Associate Professor, Department of Pathology, Kasturba Medical College, Mangaluru, Karnataka, India.Assistant Professor, Department of Pathology, Kasturba Medical College, Mangaluru, Karnataka, India.Assistant Professor, Department of Pathology, Kasturba Medical College, Mangaluru, Karnataka, India.Introduction: Castleman Disease (CD) is a rare lymphoproliferative disorder with heterogenous clinical and pathological features. It is a rare disease with mention in the rare disease data of the orphanet. It can present as unicentric or multicentric disease. Hyaline vascular variant and plasma cell variant are the two pathological subtypes. Hyaline vascular variant accounts for nearly 80% to 90% of unicentric cases. Hyaline vascular subtype variant has follicular and stroma rich subtype. Aim: To study the histomorphologic spectrum of hyaline vascular variant of CD. Materials and Methods: Retrospective cross-sectional, observational study was undertaken from the archival data between January 2009 and April 2015. Only ten cases of hyaline vascular CD were identified after studying the histomorphological characteristics. Both follicular and interfollicular changes were studied in detail. Results: The age of presentation ranged from 17 years to 59 years. Seven out of 10 cases were female. Site of presentation included cervical, inguinal, retroperitoneal, intra-abdominal and axillary. Six cases showed predominant follicular change. Two cases were sclerotic subtype. Two cases showed both follicular and interfollicular changes in equal proportion. Distribution of follicles throughout the lymphnode was seen in eight cases. Uniform sized follicles seen in seven out of ten cases. Small germinal centre with lymphocyte depletion was one of the uniform features seen in all 10 cases. Numerous high endothelial vessels were seen in nine cases. Twinning of germinal centre was seen in two cases. All ten cases showed concentric rings of small lymphocytes. Lollipop pattern was relatively rare feature seen in only two cases. Conclusion: Hyaline vascular variant of CD has considerable morphologic variation with few consistent features seen in most of the cases.https://jcdr.net/articles/PDF/10326/29415_CE[Ra]_F(Sh)_PF1(P_RB)_PFA(P_VSU).pdffollicularinterfollicularlymph node |
| spellingShingle | Chaithra Gowthuvalli Venkataramana Hema Kini Debarshi Saha Sharada Rai Deepa Sowkur Anandarama Adiga Ranjitha Rao Cheryl Sarah Philipose Histomorphologic Spectrum in Hyaline Vascular Variant of Castleman Disease Journal of Clinical and Diagnostic Research follicular interfollicular lymph node |
| title | Histomorphologic Spectrum in Hyaline Vascular Variant of Castleman Disease |
| title_full | Histomorphologic Spectrum in Hyaline Vascular Variant of Castleman Disease |
| title_fullStr | Histomorphologic Spectrum in Hyaline Vascular Variant of Castleman Disease |
| title_full_unstemmed | Histomorphologic Spectrum in Hyaline Vascular Variant of Castleman Disease |
| title_short | Histomorphologic Spectrum in Hyaline Vascular Variant of Castleman Disease |
| title_sort | histomorphologic spectrum in hyaline vascular variant of castleman disease |
| topic | follicular interfollicular lymph node |
| url | https://jcdr.net/articles/PDF/10326/29415_CE[Ra]_F(Sh)_PF1(P_RB)_PFA(P_VSU).pdf |
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