How Long Are Reperfusion Therapies Beneficial for Patients after Stroke Onset? Lessons from Lethal Ischemia Following Early Reperfusion in a Mouse Model of Stroke
Ischemic stroke caused by cerebral artery occlusion induces neurological deficits because of cell damage or death in the central nervous system. Given the recent therapeutic advances in reperfusion therapies, some patients can now recover from an ischemic stroke with no sequelae. Currently, reperfus...
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MDPI AG
2020-09-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/21/17/6360 |
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| author | Takayuki Nakagomi Yasue Tanaka Nami Nakagomi Tomohiro Matsuyama Shinichi Yoshimura |
| author_facet | Takayuki Nakagomi Yasue Tanaka Nami Nakagomi Tomohiro Matsuyama Shinichi Yoshimura |
| author_sort | Takayuki Nakagomi |
| collection | DOAJ |
| description | Ischemic stroke caused by cerebral artery occlusion induces neurological deficits because of cell damage or death in the central nervous system. Given the recent therapeutic advances in reperfusion therapies, some patients can now recover from an ischemic stroke with no sequelae. Currently, reperfusion therapies focus on rescuing neural lineage cells that survive in spite of decreases in cerebral blood flow. However, vascular lineage cells are known to be more resistant to ischemia/hypoxia than neural lineage cells. This indicates that ischemic areas of the brain experience neural cell death but without vascular cell death. Emerging evidence suggests that if a vascular cell-mediated healing system is present within ischemic areas following reperfusion, the therapeutic time window can be extended for patients with stroke. In this review, we present our comments on this subject based upon recent findings from lethal ischemia following reperfusion in a mouse model of stroke. |
| first_indexed | 2024-03-10T16:38:25Z |
| format | Article |
| id | doaj.art-0c0d1fbb61fb48b7b12acb2ec5697dfd |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T16:38:25Z |
| publishDate | 2020-09-01 |
| publisher | MDPI AG |
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| series | International Journal of Molecular Sciences |
| spelling | doaj.art-0c0d1fbb61fb48b7b12acb2ec5697dfd2023-11-20T12:14:35ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672020-09-012117636010.3390/ijms21176360How Long Are Reperfusion Therapies Beneficial for Patients after Stroke Onset? Lessons from Lethal Ischemia Following Early Reperfusion in a Mouse Model of StrokeTakayuki Nakagomi0Yasue Tanaka1Nami Nakagomi2Tomohiro Matsuyama3Shinichi Yoshimura4Institute for Advanced Medical Sciences, Hyogo College of Medicine, 1-1 Mukogawacho, Nishinomiya 663-8501, JapanDepartment of Neurosurgery, Hyogo College of Medicine, 1-1 Mukogawacho, Nishinomiya 663-8501, JapanDepartment of Surgical Pathology, Hyogo College of Medicine, 1-1 Mukogawacho, Nishinomiya 663-8501, JapanDepartment of Therapeutic Progress in Brain Diseases, Hyogo College of Medicine, 1-1 Mukogawacho, Nishinomiya 663-8501, JapanInstitute for Advanced Medical Sciences, Hyogo College of Medicine, 1-1 Mukogawacho, Nishinomiya 663-8501, JapanIschemic stroke caused by cerebral artery occlusion induces neurological deficits because of cell damage or death in the central nervous system. Given the recent therapeutic advances in reperfusion therapies, some patients can now recover from an ischemic stroke with no sequelae. Currently, reperfusion therapies focus on rescuing neural lineage cells that survive in spite of decreases in cerebral blood flow. However, vascular lineage cells are known to be more resistant to ischemia/hypoxia than neural lineage cells. This indicates that ischemic areas of the brain experience neural cell death but without vascular cell death. Emerging evidence suggests that if a vascular cell-mediated healing system is present within ischemic areas following reperfusion, the therapeutic time window can be extended for patients with stroke. In this review, we present our comments on this subject based upon recent findings from lethal ischemia following reperfusion in a mouse model of stroke.https://www.mdpi.com/1422-0067/21/17/6360ischemic strokereperfusionhistopathologyneural cellsvascular cells |
| spellingShingle | Takayuki Nakagomi Yasue Tanaka Nami Nakagomi Tomohiro Matsuyama Shinichi Yoshimura How Long Are Reperfusion Therapies Beneficial for Patients after Stroke Onset? Lessons from Lethal Ischemia Following Early Reperfusion in a Mouse Model of Stroke International Journal of Molecular Sciences ischemic stroke reperfusion histopathology neural cells vascular cells |
| title | How Long Are Reperfusion Therapies Beneficial for Patients after Stroke Onset? Lessons from Lethal Ischemia Following Early Reperfusion in a Mouse Model of Stroke |
| title_full | How Long Are Reperfusion Therapies Beneficial for Patients after Stroke Onset? Lessons from Lethal Ischemia Following Early Reperfusion in a Mouse Model of Stroke |
| title_fullStr | How Long Are Reperfusion Therapies Beneficial for Patients after Stroke Onset? Lessons from Lethal Ischemia Following Early Reperfusion in a Mouse Model of Stroke |
| title_full_unstemmed | How Long Are Reperfusion Therapies Beneficial for Patients after Stroke Onset? Lessons from Lethal Ischemia Following Early Reperfusion in a Mouse Model of Stroke |
| title_short | How Long Are Reperfusion Therapies Beneficial for Patients after Stroke Onset? Lessons from Lethal Ischemia Following Early Reperfusion in a Mouse Model of Stroke |
| title_sort | how long are reperfusion therapies beneficial for patients after stroke onset lessons from lethal ischemia following early reperfusion in a mouse model of stroke |
| topic | ischemic stroke reperfusion histopathology neural cells vascular cells |
| url | https://www.mdpi.com/1422-0067/21/17/6360 |
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