| Summary: | Nasopharyngeal cancer is a relatively rare cancer type, it is most common in southeast Asia and north Africa, it can be presented with nonspecific symptoms, making it challenging to diagnose. However, it remains a significant cancer to diagnose and treat early, as it can be aggressive and difficult to manage in its advanced stages. We report the case of a 48-year-old man who presented with isolated neck swelling, which was later found to be caused by multiple lymphadenopathies and suspected nasopharyngeal neoplasm. Imaging confirmed a large mass in the nasopharynx and bilateral cervical adenopathy. The patient underwent neoadjuvant chemotherapy and concomitant chemo-radiation, which resulted in a partial response. However, residual tumor persisted in the nasopharynx and cervical lymph nodes, and the patient requires cervical dissection. This case highlights the importance of early diagnosis and prompt treatment of nasopharyngeal cancer.
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