Evaluation of antinociceptive effect of Petiveria alliacea (guiné) in animals
Petiveria alliacea (Phytolaccaceae) is a bush widely distributed in South America including Brazil, where it is popularly known as "guiné", pipi", "tipi" or "erva-de-tipi". Brazilian folk medicine attributes to the hot water infusion of its roots or leaves the foll...
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| Format: | Article |
| Language: | English |
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Fundação Oswaldo Cruz (FIOCRUZ)
1991-01-01
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| Series: | Memorias do Instituto Oswaldo Cruz |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761991000600035 |
| _version_ | 1827842567843086336 |
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| author | Thereza C. M. de Lima Gina S. Morato Reinaldo N. Takahashi |
| author_facet | Thereza C. M. de Lima Gina S. Morato Reinaldo N. Takahashi |
| author_sort | Thereza C. M. de Lima |
| collection | DOAJ |
| description | Petiveria alliacea (Phytolaccaceae) is a bush widely distributed in South America including Brazil, where it is popularly known as "guiné", pipi", "tipi" or "erva-de-tipi". Brazilian folk medicine attributes to the hot water infusion of its roots or leaves the following pharmacologicalproperties: antipyretic, antispasmodic, abortifacient, antirrheumatic, diuretic, analgesic and sedative. The present study has evaluated the alleged effects of P. alliacea on central nervous system (CNS), particularly, the sedative and analgesic properties of root crude aqueous extract of this plant in mice and rats. This extract showed an antinociceptive effect in acetic acid - acetylcholine - and hypertonic saline - induced abdominal constrictions, but not in hot-plate and tail flick tests P. alliacea did not produce any CNS depressor effect. Thus its antinociceptive action in animals can be responsible by its poplar use as an analgesic. |
| first_indexed | 2024-03-12T08:11:28Z |
| format | Article |
| id | doaj.art-0c0e5df1988042bfb9cbb081e22f5d71 |
| institution | Directory Open Access Journal |
| issn | 0074-0276 1678-8060 |
| language | English |
| last_indexed | 2024-03-12T08:11:28Z |
| publishDate | 1991-01-01 |
| publisher | Fundação Oswaldo Cruz (FIOCRUZ) |
| record_format | Article |
| series | Memorias do Instituto Oswaldo Cruz |
| spelling | doaj.art-0c0e5df1988042bfb9cbb081e22f5d712023-09-02T19:06:56ZengFundação Oswaldo Cruz (FIOCRUZ)Memorias do Instituto Oswaldo Cruz0074-02761678-80601991-01-018615315810.1590/S0074-02761991000600035Evaluation of antinociceptive effect of Petiveria alliacea (guiné) in animalsThereza C. M. de LimaGina S. MoratoReinaldo N. TakahashiPetiveria alliacea (Phytolaccaceae) is a bush widely distributed in South America including Brazil, where it is popularly known as "guiné", pipi", "tipi" or "erva-de-tipi". Brazilian folk medicine attributes to the hot water infusion of its roots or leaves the following pharmacologicalproperties: antipyretic, antispasmodic, abortifacient, antirrheumatic, diuretic, analgesic and sedative. The present study has evaluated the alleged effects of P. alliacea on central nervous system (CNS), particularly, the sedative and analgesic properties of root crude aqueous extract of this plant in mice and rats. This extract showed an antinociceptive effect in acetic acid - acetylcholine - and hypertonic saline - induced abdominal constrictions, but not in hot-plate and tail flick tests P. alliacea did not produce any CNS depressor effect. Thus its antinociceptive action in animals can be responsible by its poplar use as an analgesic.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761991000600035Petiveria alliaceacrude aqueous extractcentral pharmacological actionsantinociceptive thresholds |
| spellingShingle | Thereza C. M. de Lima Gina S. Morato Reinaldo N. Takahashi Evaluation of antinociceptive effect of Petiveria alliacea (guiné) in animals Memorias do Instituto Oswaldo Cruz Petiveria alliacea crude aqueous extract central pharmacological actions antinociceptive thresholds |
| title | Evaluation of antinociceptive effect of Petiveria alliacea (guiné) in animals |
| title_full | Evaluation of antinociceptive effect of Petiveria alliacea (guiné) in animals |
| title_fullStr | Evaluation of antinociceptive effect of Petiveria alliacea (guiné) in animals |
| title_full_unstemmed | Evaluation of antinociceptive effect of Petiveria alliacea (guiné) in animals |
| title_short | Evaluation of antinociceptive effect of Petiveria alliacea (guiné) in animals |
| title_sort | evaluation of antinociceptive effect of petiveria alliacea guine in animals |
| topic | Petiveria alliacea crude aqueous extract central pharmacological actions antinociceptive thresholds |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761991000600035 |
| work_keys_str_mv | AT therezacmdelima evaluationofantinociceptiveeffectofpetiveriaalliaceaguineinanimals AT ginasmorato evaluationofantinociceptiveeffectofpetiveriaalliaceaguineinanimals AT reinaldontakahashi evaluationofantinociceptiveeffectofpetiveriaalliaceaguineinanimals |