<i>Bacillus velezensis</i>: A Treasure House of Bioactive Compounds of Medicinal, Biocontrol and Environmental Importance
<i>Bacillus velezensis</i> gram-positive bacterium, is frequently isolated from diverse niches mainly soil, water, plant roots, and fermented foods. <i>B. velezensis</i> is ubiquitous, non-pathogenic and endospore forming. Being frequently isolated from diverse plant holobion...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-12-01
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| Series: | Forests |
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| Online Access: | https://www.mdpi.com/1999-4907/12/12/1714 |
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| author | Faizah N. Alenezi Houda Ben Slama Ali Chenari Bouket Hafsa Cherif-Silini Allaoua Silini Lenka Luptakova Justyna Anna Nowakowska Tomasz Oszako Lassaad Belbahri |
| author_facet | Faizah N. Alenezi Houda Ben Slama Ali Chenari Bouket Hafsa Cherif-Silini Allaoua Silini Lenka Luptakova Justyna Anna Nowakowska Tomasz Oszako Lassaad Belbahri |
| author_sort | Faizah N. Alenezi |
| collection | DOAJ |
| description | <i>Bacillus velezensis</i> gram-positive bacterium, is frequently isolated from diverse niches mainly soil, water, plant roots, and fermented foods. <i>B. velezensis</i> is ubiquitous, non-pathogenic and endospore forming. Being frequently isolated from diverse plant holobionts it is considered host adapted microorganism and recognized of high economic importance given its ability to promote plant growth under diverse biotic and abiotic stress conditions. Additionally, the species suppress many plant diseases, including bacterial, oomycete, and fungal diseases. It is also able after plant host root colonization to induce unique physiological situation of host plant called primed state. Primed host plants are able to respond more rapidly and/or effectively to biotic or abiotic stress. Moreover, <i>B. velezenis</i> have the ability to resist diverse environmental stresses and help host plants to cope with, including metal and xenobiotic stresses. Within species <i>B. velezensis</i> strains have unique abilities allowing them to adopt different life styles. Strain level abilities knowledge is warranted and could be inferred using the ever-expanding new genomes list available in genomes databases. Pangenome analysis and subsequent identification of core, accessory and unique genomes is actually of paramount importance to decipher species full metabolic capacities and fitness across diverse environmental conditions shaping its life style. Despite the crucial importance of the pan genome, its assessment among large number of strains remains sparse and systematic studies still needed. Extensive knowledge of the pan genome is needed to translate genome sequencing efforts into developing more efficient biocontrol agents and bio-fertilizers. In this study, a genome survey of <i>B. velezensis</i> allowed us to (a) highlight <i>B. velezensis</i> species boundaries and show that <i>Bacillus</i> suffers taxonomic imprecision that blurs the debate over species pangenome; (b) identify drivers of their successful acquisition of specific life styles and colonization of new niches; (c) describe strategies they use to promote plant growth and development; (d) reveal the unlocked strain specific orphan secondary metabolite gene clusters (biosynthetic clusters with corresponding metabolites unknown) that product identification is still awaiting to amend our knowledge of their putative role in suppression of pathogens and plant growth promotion, and (e) to describe a dynamic pangenome with a secondary metabolite rich accessory genome. |
| first_indexed | 2024-03-10T04:05:55Z |
| format | Article |
| id | doaj.art-0c12d707debb403aa17fa83537f35856 |
| institution | Directory Open Access Journal |
| issn | 1999-4907 |
| language | English |
| last_indexed | 2024-03-10T04:05:55Z |
| publishDate | 2021-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Forests |
| spelling | doaj.art-0c12d707debb403aa17fa83537f358562023-11-23T08:21:23ZengMDPI AGForests1999-49072021-12-011212171410.3390/f12121714<i>Bacillus velezensis</i>: A Treasure House of Bioactive Compounds of Medicinal, Biocontrol and Environmental ImportanceFaizah N. Alenezi0Houda Ben Slama1Ali Chenari Bouket2Hafsa Cherif-Silini3Allaoua Silini4Lenka Luptakova5Justyna Anna Nowakowska6Tomasz Oszako7Lassaad Belbahri8The Public Authority for Applied Education and Training, Adailiyah 00965, KuwaitNextBiotech, 98 Rue Ali Belhouane, Agareb 3030, TunisiaEast Azarbaijan Agricultural and Natural Resources Research and Education Center, Plant Protection Research Department, Agricultural Research, Education and Extension Organization (AREEO), Tabriz 5355179854, IranLaboratory of Applied Microbiology, Department of Microbiology, Faculty of Natural and Life Sciences, University Ferhat Abbas of Setif, Setif 19000, AlgeriaLaboratory of Applied Microbiology, Department of Microbiology, Faculty of Natural and Life Sciences, University Ferhat Abbas of Setif, Setif 19000, AlgeriaDepartment of Biology and Genetics, Institute of Biology, Zoology and Radiobiology, University of Veterinary Medicine and Pharmacy, 04181 Kosice, SlovakiaFaculty of Biology and Environmental Sciences, Institute of Biological Sciences, Cardinal Stefan Wyszynski University in Warsaw, Wóycickiego 1/3 Street, 01-938 Warsaw, PolandDepartment of Forest Protection, Forest Research Institute, 05-090 Sekocin Stary, PolandLaboratory of Soil Biology, University of Neuchatel, 2000 Neuchatel, Switzerland<i>Bacillus velezensis</i> gram-positive bacterium, is frequently isolated from diverse niches mainly soil, water, plant roots, and fermented foods. <i>B. velezensis</i> is ubiquitous, non-pathogenic and endospore forming. Being frequently isolated from diverse plant holobionts it is considered host adapted microorganism and recognized of high economic importance given its ability to promote plant growth under diverse biotic and abiotic stress conditions. Additionally, the species suppress many plant diseases, including bacterial, oomycete, and fungal diseases. It is also able after plant host root colonization to induce unique physiological situation of host plant called primed state. Primed host plants are able to respond more rapidly and/or effectively to biotic or abiotic stress. Moreover, <i>B. velezenis</i> have the ability to resist diverse environmental stresses and help host plants to cope with, including metal and xenobiotic stresses. Within species <i>B. velezensis</i> strains have unique abilities allowing them to adopt different life styles. Strain level abilities knowledge is warranted and could be inferred using the ever-expanding new genomes list available in genomes databases. Pangenome analysis and subsequent identification of core, accessory and unique genomes is actually of paramount importance to decipher species full metabolic capacities and fitness across diverse environmental conditions shaping its life style. Despite the crucial importance of the pan genome, its assessment among large number of strains remains sparse and systematic studies still needed. Extensive knowledge of the pan genome is needed to translate genome sequencing efforts into developing more efficient biocontrol agents and bio-fertilizers. In this study, a genome survey of <i>B. velezensis</i> allowed us to (a) highlight <i>B. velezensis</i> species boundaries and show that <i>Bacillus</i> suffers taxonomic imprecision that blurs the debate over species pangenome; (b) identify drivers of their successful acquisition of specific life styles and colonization of new niches; (c) describe strategies they use to promote plant growth and development; (d) reveal the unlocked strain specific orphan secondary metabolite gene clusters (biosynthetic clusters with corresponding metabolites unknown) that product identification is still awaiting to amend our knowledge of their putative role in suppression of pathogens and plant growth promotion, and (e) to describe a dynamic pangenome with a secondary metabolite rich accessory genome.https://www.mdpi.com/1999-4907/12/12/1714<i>Bacillus velezensis</i>genomesystematicsbio-fertilizerxenobiotic stressgram-positive bacterium |
| spellingShingle | Faizah N. Alenezi Houda Ben Slama Ali Chenari Bouket Hafsa Cherif-Silini Allaoua Silini Lenka Luptakova Justyna Anna Nowakowska Tomasz Oszako Lassaad Belbahri <i>Bacillus velezensis</i>: A Treasure House of Bioactive Compounds of Medicinal, Biocontrol and Environmental Importance Forests <i>Bacillus velezensis</i> genome systematics bio-fertilizer xenobiotic stress gram-positive bacterium |
| title | <i>Bacillus velezensis</i>: A Treasure House of Bioactive Compounds of Medicinal, Biocontrol and Environmental Importance |
| title_full | <i>Bacillus velezensis</i>: A Treasure House of Bioactive Compounds of Medicinal, Biocontrol and Environmental Importance |
| title_fullStr | <i>Bacillus velezensis</i>: A Treasure House of Bioactive Compounds of Medicinal, Biocontrol and Environmental Importance |
| title_full_unstemmed | <i>Bacillus velezensis</i>: A Treasure House of Bioactive Compounds of Medicinal, Biocontrol and Environmental Importance |
| title_short | <i>Bacillus velezensis</i>: A Treasure House of Bioactive Compounds of Medicinal, Biocontrol and Environmental Importance |
| title_sort | i bacillus velezensis i a treasure house of bioactive compounds of medicinal biocontrol and environmental importance |
| topic | <i>Bacillus velezensis</i> genome systematics bio-fertilizer xenobiotic stress gram-positive bacterium |
| url | https://www.mdpi.com/1999-4907/12/12/1714 |
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