Efficacy of lidocaine-prilocaine combination cream in reducing pain caused by hepatitis B injection in neonates: a randomized control trial
Background Many invasive medical procedures cause pain in neonates. Pain in this age group increases morbidity, impairs emotional bonding, and causes hyperalgesia. Combination of lidocaine and prilocaine cream is one of the topical analgesics that are easy to use and safe for neonates. Objective To...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Indonesian Pediatric Society Publishing House
2007-02-01
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| Series: | Paediatrica Indonesiana |
| Subjects: | |
| Online Access: | https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/258 |
| _version_ | 1818141415293583360 |
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| author | Nugroho Karyadiguna Soetjiningsih Soetjiningsih W. Retayasa M. Kardana |
| author_facet | Nugroho Karyadiguna Soetjiningsih Soetjiningsih W. Retayasa M. Kardana |
| author_sort | Nugroho Karyadiguna |
| collection | DOAJ |
| description | Background Many invasive medical procedures cause pain in
neonates. Pain in this age group increases morbidity, impairs
emotional bonding, and causes hyperalgesia. Combination of
lidocaine and prilocaine cream is one of the topical analgesics
that are easy to use and safe for neonates.
Objective To assess the efficacy of lidocaine-prilocaine
combination cream in reducing pain caused by intramuscular
injection of hepatitis B and to find out the correlation of sex,
gestational age, birth weight, chronological age, and method of
delivery with infant’s pain response.
Methods A double blind randomized controlled trial was
conducted on term neonates. Subjects were selected consecutively
and every subject was randomized to either receive lidocaine-
prilocaine cream or placebo one hour prior to administration of
intramuscular hepatitis B vaccine. The administration was
recorded by a handycam and the intensity of pain responses was
evaluated using DAN (Douleur Aigue Nouveau-ne) scale.
Results Of 67 subjects, the mean of DAN scale was 7.60 (95%
CI 7.27;7.95) in the lidocaine-prilocaine cream group and this
was significantly lower (P<0.0001) than in placebo group, which
was 8.82 (95% CI 8.56;9.09). ANCOVA showed that there were
no associations between sex, gestational age, birth weight,
chronological age, and method of delivery with infant’s pain
response.
Conclusion Lidocaine-prilocaine combination cream can reduce
the pain caused by intramuscular injection of hepatitis B vaccine
on term neonates. |
| first_indexed | 2024-12-11T10:59:31Z |
| format | Article |
| id | doaj.art-0c180f6c6cf14f0baa65638e10397223 |
| institution | Directory Open Access Journal |
| issn | 0030-9311 2338-476X |
| language | English |
| last_indexed | 2024-12-11T10:59:31Z |
| publishDate | 2007-02-01 |
| publisher | Indonesian Pediatric Society Publishing House |
| record_format | Article |
| series | Paediatrica Indonesiana |
| spelling | doaj.art-0c180f6c6cf14f0baa65638e103972232022-12-22T01:09:55ZengIndonesian Pediatric Society Publishing HousePaediatrica Indonesiana0030-93112338-476X2007-02-0147112610.14238/pi47.1.2007.12-6166Efficacy of lidocaine-prilocaine combination cream in reducing pain caused by hepatitis B injection in neonates: a randomized control trialNugroho KaryadigunaSoetjiningsih SoetjiningsihW. RetayasaM. KardanaBackground Many invasive medical procedures cause pain in neonates. Pain in this age group increases morbidity, impairs emotional bonding, and causes hyperalgesia. Combination of lidocaine and prilocaine cream is one of the topical analgesics that are easy to use and safe for neonates. Objective To assess the efficacy of lidocaine-prilocaine combination cream in reducing pain caused by intramuscular injection of hepatitis B and to find out the correlation of sex, gestational age, birth weight, chronological age, and method of delivery with infant’s pain response. Methods A double blind randomized controlled trial was conducted on term neonates. Subjects were selected consecutively and every subject was randomized to either receive lidocaine- prilocaine cream or placebo one hour prior to administration of intramuscular hepatitis B vaccine. The administration was recorded by a handycam and the intensity of pain responses was evaluated using DAN (Douleur Aigue Nouveau-ne) scale. Results Of 67 subjects, the mean of DAN scale was 7.60 (95% CI 7.27;7.95) in the lidocaine-prilocaine cream group and this was significantly lower (P<0.0001) than in placebo group, which was 8.82 (95% CI 8.56;9.09). ANCOVA showed that there were no associations between sex, gestational age, birth weight, chronological age, and method of delivery with infant’s pain response. Conclusion Lidocaine-prilocaine combination cream can reduce the pain caused by intramuscular injection of hepatitis B vaccine on term neonates.https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/258lidocaine-prilocaine creampainneonates |
| spellingShingle | Nugroho Karyadiguna Soetjiningsih Soetjiningsih W. Retayasa M. Kardana Efficacy of lidocaine-prilocaine combination cream in reducing pain caused by hepatitis B injection in neonates: a randomized control trial Paediatrica Indonesiana lidocaine-prilocaine cream pain neonates |
| title | Efficacy of lidocaine-prilocaine combination cream in reducing pain caused by hepatitis B injection in neonates: a randomized control trial |
| title_full | Efficacy of lidocaine-prilocaine combination cream in reducing pain caused by hepatitis B injection in neonates: a randomized control trial |
| title_fullStr | Efficacy of lidocaine-prilocaine combination cream in reducing pain caused by hepatitis B injection in neonates: a randomized control trial |
| title_full_unstemmed | Efficacy of lidocaine-prilocaine combination cream in reducing pain caused by hepatitis B injection in neonates: a randomized control trial |
| title_short | Efficacy of lidocaine-prilocaine combination cream in reducing pain caused by hepatitis B injection in neonates: a randomized control trial |
| title_sort | efficacy of lidocaine prilocaine combination cream in reducing pain caused by hepatitis b injection in neonates a randomized control trial |
| topic | lidocaine-prilocaine cream pain neonates |
| url | https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/258 |
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