Evaluation of Thiol Disulphide Homeostasis and Neutrophile Lymphocyte Ratio in Carbon Monoxide Intoxication
INTRODUCTION: The aim of this study is to search if using thiol/disulphide homeostasis together with Neutrophile Lymphocyte Ratio (NLR) which are oxidative stress markers in patients who apply to the emergency service with carbon monoxide intoxication is useful regarding diagnosis or not. METHODS: T...
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| Format: | Article |
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Ankara Yildirim Beyazit University
2020-03-01
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| Series: | Ankara Medical Journal |
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| Online Access: | https://jag.journalagent.com/z4/download_fulltext.asp?pdir=amj&un=AMJ-71542 |
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| author | Fatih Tanrıverdi Yucel Yuzbasioglu Fadime Güllü Ercan Haydar Servan Gökhan Ayhan Özhasenekler Çağdaş Yıldırım Fatih Ahmet Kahraman Funda Eren |
| author_facet | Fatih Tanrıverdi Yucel Yuzbasioglu Fadime Güllü Ercan Haydar Servan Gökhan Ayhan Özhasenekler Çağdaş Yıldırım Fatih Ahmet Kahraman Funda Eren |
| author_sort | Fatih Tanrıverdi |
| collection | DOAJ |
| description | INTRODUCTION: The aim of this study is to search if using thiol/disulphide homeostasis together with Neutrophile Lymphocyte Ratio (NLR) which are oxidative stress markers in patients who apply to the emergency service with carbon monoxide intoxication is useful regarding diagnosis or not. METHODS: The study was performed prospectively with 45 patients who applied to the emergency service between 01.01.2014 - 01.03.2015 and who were included in the study and 40 healthy persons who were determined as control group. Thiol/disulphide homeostasis parameters (Thiol, disulphide, disulphide / native thiol, disulphide / total thiol, native thiol / total thiol) and NLR which are oxidative stress markers were studied in the patient and control groups by a method which was developed newly by Erel and Neşelioğlu. RESULTS: In persons with carbon monoxide intoxication, a significant difference was detected in NT, TT, index 3 and NLR rates according to the control group. NT, TT and index 3 were found lower in the patient group, and NLR mean values were found higher in the patient group (p =0.005, < 0.001, = 0.032, < 0.001 respectively). DISCUSSION AND CONCLUSION: To use NLR together with thiol/disulphide homeostasis parameters in the diagnosis of carbon monoxide intoxication is useful regarding diagnosing in these patients. |
| first_indexed | 2024-04-10T12:39:07Z |
| format | Article |
| id | doaj.art-0c18c63a2aa2482ba0d1618a88f5eac2 |
| institution | Directory Open Access Journal |
| issn | 2148-4570 |
| language | English |
| last_indexed | 2024-04-10T12:39:07Z |
| publishDate | 2020-03-01 |
| publisher | Ankara Yildirim Beyazit University |
| record_format | Article |
| series | Ankara Medical Journal |
| spelling | doaj.art-0c18c63a2aa2482ba0d1618a88f5eac22023-02-15T16:14:23ZengAnkara Yildirim Beyazit UniversityAnkara Medical Journal2148-45702020-03-01201475610.5505/amj.2020.71542AMJ-71542Evaluation of Thiol Disulphide Homeostasis and Neutrophile Lymphocyte Ratio in Carbon Monoxide IntoxicationFatih Tanrıverdi0Yucel Yuzbasioglu1Fadime Güllü Ercan Haydar2Servan Gökhan3Ayhan Özhasenekler4Çağdaş Yıldırım5Fatih Ahmet Kahraman6Funda Eren7Department of Emergency Medicine, School of Medicine, Ankara Yıldırım Beyazıt University, AnkaraDepartment of Emergency Medicine, Keçiören Training and Research Hospital, AnkaraDepartment of General Surgery, Ankara City Hospital, AnkaraDepartment of Emergency Medicine, School of Medicine, Ankara Yıldırım Beyazıt University, AnkaraDepartment of Emergency Medicine, School of Medicine, Ankara Yıldırım Beyazıt University, AnkaraDepartment of Emergency Medicine, School of Medicine, Ankara Yıldırım Beyazıt University, AnkaraDepartment of Emergency Medicine, School of Medicine, Ankara Yıldırım Beyazıt University, AnkaraDepartment of Biochemistry, Ankara City Hospital, AnkaraINTRODUCTION: The aim of this study is to search if using thiol/disulphide homeostasis together with Neutrophile Lymphocyte Ratio (NLR) which are oxidative stress markers in patients who apply to the emergency service with carbon monoxide intoxication is useful regarding diagnosis or not. METHODS: The study was performed prospectively with 45 patients who applied to the emergency service between 01.01.2014 - 01.03.2015 and who were included in the study and 40 healthy persons who were determined as control group. Thiol/disulphide homeostasis parameters (Thiol, disulphide, disulphide / native thiol, disulphide / total thiol, native thiol / total thiol) and NLR which are oxidative stress markers were studied in the patient and control groups by a method which was developed newly by Erel and Neşelioğlu. RESULTS: In persons with carbon monoxide intoxication, a significant difference was detected in NT, TT, index 3 and NLR rates according to the control group. NT, TT and index 3 were found lower in the patient group, and NLR mean values were found higher in the patient group (p =0.005, < 0.001, = 0.032, < 0.001 respectively). DISCUSSION AND CONCLUSION: To use NLR together with thiol/disulphide homeostasis parameters in the diagnosis of carbon monoxide intoxication is useful regarding diagnosing in these patients.https://jag.journalagent.com/z4/download_fulltext.asp?pdir=amj&un=AMJ-71542carbon monoxide intoxicationnlrthiol/disulphide homeostasis. |
| spellingShingle | Fatih Tanrıverdi Yucel Yuzbasioglu Fadime Güllü Ercan Haydar Servan Gökhan Ayhan Özhasenekler Çağdaş Yıldırım Fatih Ahmet Kahraman Funda Eren Evaluation of Thiol Disulphide Homeostasis and Neutrophile Lymphocyte Ratio in Carbon Monoxide Intoxication Ankara Medical Journal carbon monoxide intoxication nlr thiol/disulphide homeostasis. |
| title | Evaluation of Thiol Disulphide Homeostasis and Neutrophile Lymphocyte Ratio in Carbon Monoxide Intoxication |
| title_full | Evaluation of Thiol Disulphide Homeostasis and Neutrophile Lymphocyte Ratio in Carbon Monoxide Intoxication |
| title_fullStr | Evaluation of Thiol Disulphide Homeostasis and Neutrophile Lymphocyte Ratio in Carbon Monoxide Intoxication |
| title_full_unstemmed | Evaluation of Thiol Disulphide Homeostasis and Neutrophile Lymphocyte Ratio in Carbon Monoxide Intoxication |
| title_short | Evaluation of Thiol Disulphide Homeostasis and Neutrophile Lymphocyte Ratio in Carbon Monoxide Intoxication |
| title_sort | evaluation of thiol disulphide homeostasis and neutrophile lymphocyte ratio in carbon monoxide intoxication |
| topic | carbon monoxide intoxication nlr thiol/disulphide homeostasis. |
| url | https://jag.journalagent.com/z4/download_fulltext.asp?pdir=amj&un=AMJ-71542 |
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