New Insights on Rotenone Resistance of Complex I Induced by the m.11778G>A/<i>MT-ND4</i> Mutation Associated with Leber’s Hereditary Optic Neuropathy

New Insights on Rotenone Resistance of Complex I Induced by the m.11778G>A/<i>MT-ND4</i> Mutation Associated with Leber’s Hereditary Optic Neuropathy

The finding that the most common mitochondrial DNA mutation m.11778G>A/<i>MT-ND4</i> (p.R340H) associated with Leber’s hereditary optic neuropathy (LHON) induces rotenone resistance has produced a long-standing debate, because it contrasts structural evidence showing that the ND4 subu...

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Bibliographic Details
Main Authors: Francesco Musiani, Laura Rigobello, Luisa Iommarini, Valerio Carelli, Mauro Degli Esposti, Anna Maria Ghelli
Format: Article
Language:English
Published: MDPI AG 2022-02-01
Series:Molecules
Subjects:
complex I
LHON
mtDNA mutations
rotenone
Online Access:https://www.mdpi.com/1420-3049/27/4/1341

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