Randomized clinical trial on the clinical effects of a toothpaste containing extra virgin olive oil, xylitol, and betaine in gingivitis
Abstract To determine the effects on gingival bleeding, dental biofilm, and salivary flow and pH in patients with gingivitis of using toothpaste with extra-virgin olive oil (EVOO), xylitol, and betaine in comparison to a placebo or commercial toothpaste. This controlled, double blinded, and multicen...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2023-04-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-023-33521-4 |
| _version_ | 1797841054417813504 |
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| author | Alejandro Rodríguez-Agurto Manuel Bravo Antonio Magán-Fernandez Ana López-Toruño Ricardo Muñoz Joaquín Ferrer Francisco Mesa |
| author_facet | Alejandro Rodríguez-Agurto Manuel Bravo Antonio Magán-Fernandez Ana López-Toruño Ricardo Muñoz Joaquín Ferrer Francisco Mesa |
| author_sort | Alejandro Rodríguez-Agurto |
| collection | DOAJ |
| description | Abstract To determine the effects on gingival bleeding, dental biofilm, and salivary flow and pH in patients with gingivitis of using toothpaste with extra-virgin olive oil (EVOO), xylitol, and betaine in comparison to a placebo or commercial toothpaste. This controlled, double blinded, and multicenter randomized clinical trial included patients with gingivitis randomly assigned to one of three groups: test group (EVOO, xylitol, and betaine toothpaste), control group 1 (placebo toothpaste), or control group 2 (commercial toothpaste). Percentage supragingival biofilm and gingival bleeding were evaluated at baseline (T0), 2 months (T2), and 4 months (T4), measuring non-stimulated salivary flow and salivary pH. Comparisons were performed between and within groups. The final study sample comprised 20 in the test group, 21 in control group 1, and 20 in control group 2. In comparison to control group 1, the test group showed significantly greater decreases in gingival bleeding between T4 and T0 (p = 0.02) and in biofilm between T2 and T0 (p = 0.02) and between T4 and T0 (p = 0.01). In the test group, salivary flow significantly increased between T2 and T0 (p = 0.01), while pH alkalization was significantly greater between T4 and T0 versus control group 2 (p = 0.01) and close-to-significantly greater versus control group 1 (p = 0.06). The toothpaste with EVOO, xylitol, and betaine obtained the best outcomes in patients with gingivitis, who showed reductions in gingival bleeding and supragingival biofilm and an increase in pH at 4 months in comparison to a commercial toothpaste. |
| first_indexed | 2024-04-09T16:24:47Z |
| format | Article |
| id | doaj.art-0c1a374147f54d078c980923cc403a43 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-09T16:24:47Z |
| publishDate | 2023-04-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-0c1a374147f54d078c980923cc403a432023-04-23T11:16:42ZengNature PortfolioScientific Reports2045-23222023-04-011311810.1038/s41598-023-33521-4Randomized clinical trial on the clinical effects of a toothpaste containing extra virgin olive oil, xylitol, and betaine in gingivitisAlejandro Rodríguez-Agurto0Manuel Bravo1Antonio Magán-Fernandez2Ana López-Toruño3Ricardo Muñoz4Joaquín Ferrer5Francisco Mesa6Department of Periodontics, School of Dentistry, University of GranadaDepartment of Preventive and Community Dentistry, University of GranadaDepartment of Periodontics, School of Dentistry, University of GranadaDepartment of Periodontics, School of Dentistry, University of GranadaOdontólogo, Centro de Salud de Loja, Unidad de Salud Bucodental Distrito Metropolitano, Servicio Andaluz de SaludOdontólogo, Centro de Salud de Huétor-Tajar, Unidad de Salud Bucodental Distrito Metropolitano, Servicio Andaluz de SaludDepartment of Periodontics, School of Dentistry, University of GranadaAbstract To determine the effects on gingival bleeding, dental biofilm, and salivary flow and pH in patients with gingivitis of using toothpaste with extra-virgin olive oil (EVOO), xylitol, and betaine in comparison to a placebo or commercial toothpaste. This controlled, double blinded, and multicenter randomized clinical trial included patients with gingivitis randomly assigned to one of three groups: test group (EVOO, xylitol, and betaine toothpaste), control group 1 (placebo toothpaste), or control group 2 (commercial toothpaste). Percentage supragingival biofilm and gingival bleeding were evaluated at baseline (T0), 2 months (T2), and 4 months (T4), measuring non-stimulated salivary flow and salivary pH. Comparisons were performed between and within groups. The final study sample comprised 20 in the test group, 21 in control group 1, and 20 in control group 2. In comparison to control group 1, the test group showed significantly greater decreases in gingival bleeding between T4 and T0 (p = 0.02) and in biofilm between T2 and T0 (p = 0.02) and between T4 and T0 (p = 0.01). In the test group, salivary flow significantly increased between T2 and T0 (p = 0.01), while pH alkalization was significantly greater between T4 and T0 versus control group 2 (p = 0.01) and close-to-significantly greater versus control group 1 (p = 0.06). The toothpaste with EVOO, xylitol, and betaine obtained the best outcomes in patients with gingivitis, who showed reductions in gingival bleeding and supragingival biofilm and an increase in pH at 4 months in comparison to a commercial toothpaste.https://doi.org/10.1038/s41598-023-33521-4 |
| spellingShingle | Alejandro Rodríguez-Agurto Manuel Bravo Antonio Magán-Fernandez Ana López-Toruño Ricardo Muñoz Joaquín Ferrer Francisco Mesa Randomized clinical trial on the clinical effects of a toothpaste containing extra virgin olive oil, xylitol, and betaine in gingivitis Scientific Reports |
| title | Randomized clinical trial on the clinical effects of a toothpaste containing extra virgin olive oil, xylitol, and betaine in gingivitis |
| title_full | Randomized clinical trial on the clinical effects of a toothpaste containing extra virgin olive oil, xylitol, and betaine in gingivitis |
| title_fullStr | Randomized clinical trial on the clinical effects of a toothpaste containing extra virgin olive oil, xylitol, and betaine in gingivitis |
| title_full_unstemmed | Randomized clinical trial on the clinical effects of a toothpaste containing extra virgin olive oil, xylitol, and betaine in gingivitis |
| title_short | Randomized clinical trial on the clinical effects of a toothpaste containing extra virgin olive oil, xylitol, and betaine in gingivitis |
| title_sort | randomized clinical trial on the clinical effects of a toothpaste containing extra virgin olive oil xylitol and betaine in gingivitis |
| url | https://doi.org/10.1038/s41598-023-33521-4 |
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