Gas6 Attenuates Sepsis-Induced Tight Junction Injury and Vascular Endothelial Hyperpermeability via the Axl/NF-κB Signaling Pathway

Gas6 Attenuates Sepsis-Induced Tight Junction Injury and Vascular Endothelial Hyperpermeability via the Axl/NF-κB Signaling Pathway

Vascular endothelial functional dysregulation and barrier disruption are involved the initiation and development of sepsis. Growth arrest-specific protein 6 (Gas6), one of the endogenous ligands of TAM receptors (Tyro3, Axl, and Mertk), is confirmed to have beneficial functions in hemostasis, inflam...

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Bibliographic Details
Main Authors: Jingjing Ni, Miaotong Lin, Yangjie Jin, Jiajia Li, Yayong Guo, Jindong Zhou, Guangliang Hong, Guangju Zhao, Zhongqiu Lu
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-06-01
Series:Frontiers in Pharmacology
Subjects:
Gas6
multi-organ dysfunction syndrome
vascular endothelial hyperpermeability
tight junctions
Axl/NF-κB
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.00662/full

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