Comparison of VSV Pseudovirus and Focus Reduction Neutralization Assays for Measurement of Anti-Andes orthohantavirus Neutralizing Antibodies in Patient Samples

Comparison of VSV Pseudovirus and Focus Reduction Neutralization Assays for Measurement of Anti-Andes orthohantavirus Neutralizing Antibodies in Patient Samples

Andes orthohantavirus (ANDV) is the etiologic agent of hantavirus cardiopulmonary syndrome (HCPS), which has a case fatality rate around 35%, with no effective treatment or vaccine available. ANDV neutralizing antibody (NAb) measurements are important for the evaluation of the immune response follow...

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Bibliographic Details
Main Authors: Cecilia Vial, Annalis Whitaker, Jan Wilhelm, Jimena Ovalle, Ruth Perez, Francisca Valdivieso, Marcela Ferres, Constanza Martinez-Valdebenito, Philip Eisenhauer, Gregory J. Mertz, Jay W. Hooper, Jason W. Botten, Pablo A. Vial
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-09-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
Andes orthohantavirus (ANDV)
hantavirus cardiopulmonary syndrome (HCPS)
orthohantavirus
vesicular stomatitis virus (VSV) pseudovirus
neutralizing antibodies
Online Access:https://www.frontiersin.org/article/10.3389/fcimb.2020.00444/full

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