Sentinel Lymph Node Biopsy vs. Observation in Thin Melanoma: A Multicenter Propensity Score Matching Study
The therapeutic value of sentinel lymph node biopsy (SLNB) in thin melanoma remains controversial. The aim of this study is to determine the role of SLNB in the survival of thin melanomas (≤1 mm). A multicenter retrospective observational study was designed. A propensity score matching was performed...
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MDPI AG
2021-12-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/10/24/5878 |
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| author | Antonio Tejera-Vaquerizo Aram Boada Simone Ribero Susana Puig Sabela Paradela David Moreno-Ramírez Javier Cañueto Blanca de Unamuno-Bustos Ana Brinca Miguel A. Descalzo-Gallego Simona Osella-Abate Paola Cassoni Sebastian Podlipnik Cristina Carrera Sergi Vidal-Sicart Ramón Pigem Agustí Toll Ramón Rull Llucìa Alos Celia Requena Isidro Bolumar Víctor Traves Ángel Pla Almudena Fernández-Orland Ane Jaka María Teresa Fernández-Figueras Nina Anika Richarz Ricardo Vieira Rafael Botella-Estrada Concepción Román-Curto Lara Ferrándiz-Pulido Nicolás Iglesias-Pena Carlos Ferrándiz Josep Malvehy Pietro Quaglino Eduardo Nagore |
| author_facet | Antonio Tejera-Vaquerizo Aram Boada Simone Ribero Susana Puig Sabela Paradela David Moreno-Ramírez Javier Cañueto Blanca de Unamuno-Bustos Ana Brinca Miguel A. Descalzo-Gallego Simona Osella-Abate Paola Cassoni Sebastian Podlipnik Cristina Carrera Sergi Vidal-Sicart Ramón Pigem Agustí Toll Ramón Rull Llucìa Alos Celia Requena Isidro Bolumar Víctor Traves Ángel Pla Almudena Fernández-Orland Ane Jaka María Teresa Fernández-Figueras Nina Anika Richarz Ricardo Vieira Rafael Botella-Estrada Concepción Román-Curto Lara Ferrándiz-Pulido Nicolás Iglesias-Pena Carlos Ferrándiz Josep Malvehy Pietro Quaglino Eduardo Nagore |
| author_sort | Antonio Tejera-Vaquerizo |
| collection | DOAJ |
| description | The therapeutic value of sentinel lymph node biopsy (SLNB) in thin melanoma remains controversial. The aim of this study is to determine the role of SLNB in the survival of thin melanomas (≤1 mm). A multicenter retrospective observational study was designed. A propensity score matching was performed to compare patients who underwent SLNB vs. observation. A multivariate Cox regression was used. A total of 1438 patients were matched by propensity score. There were no significant differences in melanoma-specific survival (MSS) between the SLNB and observation groups. Predictors of MSS in the multivariate model were age, tumor thickness, ulceration, and interferon treatment. Results were similar for disease-free survival and overall survival. The 5- and 10-year MSS rates for SLN-negative and -positive patients were 98.5% vs. 77.3% (<i>p</i> < 0.001) and 97.3% vs. 68.7% (<i>p</i> < 0.001), respectively. SLNB does not improve MSS in patients with thin melanoma. It also had no impact on DSF or OS. However, a considerable difference in MSS, DFS, and OS between SLN-positive and -negative patients exists, confirming its value as a prognostic procedure and therefore we recommend discussing the option of SLNB with patients. |
| first_indexed | 2024-03-10T03:50:23Z |
| format | Article |
| id | doaj.art-0c20589bcade4d6aa15ed09c13d6b449 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-10T03:50:23Z |
| publishDate | 2021-12-01 |
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| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-0c20589bcade4d6aa15ed09c13d6b4492023-11-23T08:57:32ZengMDPI AGJournal of Clinical Medicine2077-03832021-12-011024587810.3390/jcm10245878Sentinel Lymph Node Biopsy vs. Observation in Thin Melanoma: A Multicenter Propensity Score Matching StudyAntonio Tejera-Vaquerizo0Aram Boada1Simone Ribero2Susana Puig3Sabela Paradela4David Moreno-Ramírez5Javier Cañueto6Blanca de Unamuno-Bustos7Ana Brinca8Miguel A. Descalzo-Gallego9Simona Osella-Abate10Paola Cassoni11Sebastian Podlipnik12Cristina Carrera13Sergi Vidal-Sicart14Ramón Pigem15Agustí Toll16Ramón Rull17Llucìa Alos18Celia Requena19Isidro Bolumar20Víctor Traves21Ángel Pla22Almudena Fernández-Orland23Ane Jaka24María Teresa Fernández-Figueras25Nina Anika Richarz26Ricardo Vieira27Rafael Botella-Estrada28Concepción Román-Curto29Lara Ferrándiz-Pulido30Nicolás Iglesias-Pena31Carlos Ferrándiz32Josep Malvehy33Pietro Quaglino34Eduardo Nagore35Dermatology Department, Instituto Dermatológico GlobalDerm, 14700 Palma del Río, SpainDermatology Department, Hospital Universitari Germans Trials i Pujol, Institut d’Investigació Germans Trias i Pujol, Universitat Autònoma de Barcelona, 08916 Badalona, SpainMedical Sciences Department, Section of Dermatology, University of Turin, 10124 Turin, ItalyMelanoma Unit, Dermatology Department, Hospital Clinic, Universitat de Barcelona, Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), 08036 Barcelona, SpainDepartamento de Dermatología, Hospital Universitario de la Coruña, 15006 La Coruña, SpainMelanoma Unit, Medical-&-Surgical Dermatology Department, Hospital Universitario Virgen Macarena, 41009 Sevilla, SpainDermatology Department, Complejo Asistencial Universitario de Salamanca, 37007 Salamanca, SpainDermatology Department, Hospital Universitario La Fe, 46126 Valencia, SpainDepartament of Dermatology, University Hospital of Coimbra, 3000-075 Coimbra, PortugalUnidad de Investigación, Fundación Piel Sana, Academia Española de Dermatología, 28008 Madrid, SpainMedical Sciences Department, Section of Surgical Pathology, University of Turin, 10124 Turin, ItalyMedical Sciences Department, Section of Surgical Pathology, University of Turin, 10124 Turin, ItalyMelanoma Unit, Dermatology Department, Hospital Clinic, Universitat de Barcelona, Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), 08036 Barcelona, SpainMelanoma Unit, Dermatology Department, Hospital Clinic, Universitat de Barcelona, Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), 08036 Barcelona, SpainNuclear Medicine Department, Hospital Clinic Barcelona, Universitat de Barcelona, Institut d’investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), 08036 Barcelona, SpainMelanoma Unit, Dermatology Department, Hospital Clinic, Universitat de Barcelona, Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), 08036 Barcelona, SpainMelanoma Unit, Dermatology Department, Hospital Clinic, Universitat de Barcelona, Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), 08036 Barcelona, SpainSurgery Department, Hospital Clinic, Universidad de Barcelona, 08036 Barcelona, SpainPathology Department, Hospital Clinic, Universidad de Barcelona, 08036 Barcelona, SpainDermatology Department, Instituto Valenciano de Oncología, 46009 Valencia, SpainSurgery Department, Instituto Valenciano de Oncología, 46009 Valencia, SpainPathology Department, Instituto Valenciano de Oncología, 46009 Valencia, SpainOtorhinolaringology Department, Instituto Valenciano de Oncología, 46009 Valencia, SpainMelanoma Unit, Medical-&-Surgical Dermatology Department, Hospital Universitario Virgen Macarena, 41009 Sevilla, SpainDermatology Department, Hospital Universitari Germans Trials i Pujol, Institut d’Investigació Germans Trias i Pujol, Universitat Autònoma de Barcelona, 08916 Badalona, SpainPathology Department, Hospital Universitari Germans Trial i Pujol, 08916 Badalona, SpainDermatology Department, Hospital Universitari Germans Trials i Pujol, Institut d’Investigació Germans Trias i Pujol, Universitat Autònoma de Barcelona, 08916 Badalona, SpainDepartament of Dermatology, University Hospital of Coimbra, 3000-075 Coimbra, PortugalDermatology Department, Hospital Universitario La Fe, 46126 Valencia, SpainDermatology Department, Complejo Asistencial Universitario de Salamanca, 37007 Salamanca, SpainMelanoma Unit, Medical-&-Surgical Dermatology Department, Hospital Universitario Virgen Macarena, 41009 Sevilla, SpainDepartamento de Dermatología, Hospital Universitario de la Coruña, 15006 La Coruña, SpainDermatology Department, Hospital Universitari Germans Trials i Pujol, Institut d’Investigació Germans Trias i Pujol, Universitat Autònoma de Barcelona, 08916 Badalona, SpainMelanoma Unit, Dermatology Department, Hospital Clinic, Universitat de Barcelona, Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), 08036 Barcelona, SpainMedical Sciences Department, Section of Dermatology, University of Turin, 10124 Turin, ItalyDermatology Department, Instituto Valenciano de Oncología, 46009 Valencia, SpainThe therapeutic value of sentinel lymph node biopsy (SLNB) in thin melanoma remains controversial. The aim of this study is to determine the role of SLNB in the survival of thin melanomas (≤1 mm). A multicenter retrospective observational study was designed. A propensity score matching was performed to compare patients who underwent SLNB vs. observation. A multivariate Cox regression was used. A total of 1438 patients were matched by propensity score. There were no significant differences in melanoma-specific survival (MSS) between the SLNB and observation groups. Predictors of MSS in the multivariate model were age, tumor thickness, ulceration, and interferon treatment. Results were similar for disease-free survival and overall survival. The 5- and 10-year MSS rates for SLN-negative and -positive patients were 98.5% vs. 77.3% (<i>p</i> < 0.001) and 97.3% vs. 68.7% (<i>p</i> < 0.001), respectively. SLNB does not improve MSS in patients with thin melanoma. It also had no impact on DSF or OS. However, a considerable difference in MSS, DFS, and OS between SLN-positive and -negative patients exists, confirming its value as a prognostic procedure and therefore we recommend discussing the option of SLNB with patients.https://www.mdpi.com/2077-0383/10/24/5878melanomasentinel lymph node biopsysurvival |
| spellingShingle | Antonio Tejera-Vaquerizo Aram Boada Simone Ribero Susana Puig Sabela Paradela David Moreno-Ramírez Javier Cañueto Blanca de Unamuno-Bustos Ana Brinca Miguel A. Descalzo-Gallego Simona Osella-Abate Paola Cassoni Sebastian Podlipnik Cristina Carrera Sergi Vidal-Sicart Ramón Pigem Agustí Toll Ramón Rull Llucìa Alos Celia Requena Isidro Bolumar Víctor Traves Ángel Pla Almudena Fernández-Orland Ane Jaka María Teresa Fernández-Figueras Nina Anika Richarz Ricardo Vieira Rafael Botella-Estrada Concepción Román-Curto Lara Ferrándiz-Pulido Nicolás Iglesias-Pena Carlos Ferrándiz Josep Malvehy Pietro Quaglino Eduardo Nagore Sentinel Lymph Node Biopsy vs. Observation in Thin Melanoma: A Multicenter Propensity Score Matching Study Journal of Clinical Medicine melanoma sentinel lymph node biopsy survival |
| title | Sentinel Lymph Node Biopsy vs. Observation in Thin Melanoma: A Multicenter Propensity Score Matching Study |
| title_full | Sentinel Lymph Node Biopsy vs. Observation in Thin Melanoma: A Multicenter Propensity Score Matching Study |
| title_fullStr | Sentinel Lymph Node Biopsy vs. Observation in Thin Melanoma: A Multicenter Propensity Score Matching Study |
| title_full_unstemmed | Sentinel Lymph Node Biopsy vs. Observation in Thin Melanoma: A Multicenter Propensity Score Matching Study |
| title_short | Sentinel Lymph Node Biopsy vs. Observation in Thin Melanoma: A Multicenter Propensity Score Matching Study |
| title_sort | sentinel lymph node biopsy vs observation in thin melanoma a multicenter propensity score matching study |
| topic | melanoma sentinel lymph node biopsy survival |
| url | https://www.mdpi.com/2077-0383/10/24/5878 |
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