Electrocardiographic Changes in Thalassemia Major Patients and their Association with Serum Ferritin Levels
Background: To evaluate the use of electrocardiography (ECG) in thalassemia major patients, for the early detection of iron overload induced cardiac complications. Methods: Serum ferritin analysis and a standard 12 lead ECG was performed on 135 thalassemia major patients. SPSS Version 20 was used fo...
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| Format: | Article |
| Language: | English |
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Rawalpindi Medical University
2015-12-01
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| Series: | Journal of Rawalpindi Medical College |
| Subjects: | |
| Online Access: | https://www.journalrmc.com/index.php/JRMC/article/view/233 |
| _version_ | 1818208473441107968 |
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| author | Amna Faruqi Faruqi |
| author_facet | Amna Faruqi Faruqi |
| author_sort | Amna Faruqi Faruqi |
| collection | DOAJ |
| description | Background: To evaluate the use of electrocardiography (ECG) in thalassemia major patients, for the early detection of iron overload induced cardiac complications.
Methods: Serum ferritin analysis and a standard 12 lead ECG was performed on 135 thalassemia major patients. SPSS Version 20 was used for data analysis. For categorical variables, frequencies and percentages were calculated. For quantitative variables, mean with standard deviation was calculated. Chi Square test was used for finding association between different ECG changes and serum ferritin levels. A p value of <0.05 was considered to be statistically significant.
Results: Patients ranged in age from 7-30 years. Males constituted 51 %. The mean serum ferritin level was 6062.61 + 3641.796 ng/ml. There was no significant difference between the mean ferritin levels in males and females (p =0.366) One or more abnormal electrocardiographic findings were observed in 88.1% of patients. The most commonly observed findings were flattening of the T wave, followed by arrthymias, tachycardia, pathological T wave inversions, long QT interval, left ventricular hypertrophy (LVH) and right ventricular hypertrophy (RVH). Long QT interval was the only abnormality found to be significantly associated with high ferritin levels. (p =0.001).
Conclusion: ECG can be used for monitoring thalassaemia major patients for the development of cardiac complications, especially where magnetic |
| first_indexed | 2024-12-12T04:45:22Z |
| format | Article |
| id | doaj.art-0c20607cbe0748b6862689238f267481 |
| institution | Directory Open Access Journal |
| issn | 1683-3562 1683-3570 |
| language | English |
| last_indexed | 2024-12-12T04:45:22Z |
| publishDate | 2015-12-01 |
| publisher | Rawalpindi Medical University |
| record_format | Article |
| series | Journal of Rawalpindi Medical College |
| spelling | doaj.art-0c20607cbe0748b6862689238f2674812022-12-22T00:37:38ZengRawalpindi Medical UniversityJournal of Rawalpindi Medical College1683-35621683-35702015-12-01193Electrocardiographic Changes in Thalassemia Major Patients and their Association with Serum Ferritin LevelsAmna Faruqi Faruqi0Department of Physiology, Islamabad Medical & Dental College, IslamabadBackground: To evaluate the use of electrocardiography (ECG) in thalassemia major patients, for the early detection of iron overload induced cardiac complications. Methods: Serum ferritin analysis and a standard 12 lead ECG was performed on 135 thalassemia major patients. SPSS Version 20 was used for data analysis. For categorical variables, frequencies and percentages were calculated. For quantitative variables, mean with standard deviation was calculated. Chi Square test was used for finding association between different ECG changes and serum ferritin levels. A p value of <0.05 was considered to be statistically significant. Results: Patients ranged in age from 7-30 years. Males constituted 51 %. The mean serum ferritin level was 6062.61 + 3641.796 ng/ml. There was no significant difference between the mean ferritin levels in males and females (p =0.366) One or more abnormal electrocardiographic findings were observed in 88.1% of patients. The most commonly observed findings were flattening of the T wave, followed by arrthymias, tachycardia, pathological T wave inversions, long QT interval, left ventricular hypertrophy (LVH) and right ventricular hypertrophy (RVH). Long QT interval was the only abnormality found to be significantly associated with high ferritin levels. (p =0.001). Conclusion: ECG can be used for monitoring thalassaemia major patients for the development of cardiac complications, especially where magnetichttps://www.journalrmc.com/index.php/JRMC/article/view/233Thalassemia MajorIron overloadECG,Ferritin |
| spellingShingle | Amna Faruqi Faruqi Electrocardiographic Changes in Thalassemia Major Patients and their Association with Serum Ferritin Levels Journal of Rawalpindi Medical College Thalassemia Major Iron overload ECG, Ferritin |
| title | Electrocardiographic Changes in Thalassemia Major Patients and their Association with Serum Ferritin Levels |
| title_full | Electrocardiographic Changes in Thalassemia Major Patients and their Association with Serum Ferritin Levels |
| title_fullStr | Electrocardiographic Changes in Thalassemia Major Patients and their Association with Serum Ferritin Levels |
| title_full_unstemmed | Electrocardiographic Changes in Thalassemia Major Patients and their Association with Serum Ferritin Levels |
| title_short | Electrocardiographic Changes in Thalassemia Major Patients and their Association with Serum Ferritin Levels |
| title_sort | electrocardiographic changes in thalassemia major patients and their association with serum ferritin levels |
| topic | Thalassemia Major Iron overload ECG, Ferritin |
| url | https://www.journalrmc.com/index.php/JRMC/article/view/233 |
| work_keys_str_mv | AT amnafaruqifaruqi electrocardiographicchangesinthalassemiamajorpatientsandtheirassociationwithserumferritinlevels |