The entanglement of extracellular matrix molecules and immune checkpoint inhibitors in cancer: a systematic review of the literature
IntroductionImmune-checkpoint inhibitors (ICIs) have emerged as a core pillar of cancer therapy as single agents or in combination regimens both in adults and children. Unfortunately, ICIs provide a long-lasting therapeutic effect in only one third of the patients. Thus, the search for predictive bi...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-10-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1270981/full |
| _version_ | 1797262485752905728 |
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| author | Albina Fejza Greta Carobolante Evelina Poletto Lucrezia Camicia Giorgia Schinello Emanuele Di Siena Giuseppe Ricci Giuseppe Ricci Maurizio Mongiat Eva Andreuzzi |
| author_facet | Albina Fejza Greta Carobolante Evelina Poletto Lucrezia Camicia Giorgia Schinello Emanuele Di Siena Giuseppe Ricci Giuseppe Ricci Maurizio Mongiat Eva Andreuzzi |
| author_sort | Albina Fejza |
| collection | DOAJ |
| description | IntroductionImmune-checkpoint inhibitors (ICIs) have emerged as a core pillar of cancer therapy as single agents or in combination regimens both in adults and children. Unfortunately, ICIs provide a long-lasting therapeutic effect in only one third of the patients. Thus, the search for predictive biomarkers of responsiveness to ICIs remains an urgent clinical need. The efficacy of ICIs treatments is strongly affected not only by the specific characteristics of cancer cells and the levels of immune checkpoint ligands, but also by other components of the tumor microenvironment, among which the extracellular matrix (ECM) is emerging as key player. With the aim to comprehensively describe the relation between ECM and ICIs’ efficacy in cancer patients, the present review systematically evaluated the current literature regarding ECM remodeling in association with immunotherapeutic approaches.MethodsThis review followed the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) guidelines and was registered at the International Prospective Register of Systematic Reviews (PROSPERO, CRD42022351180). PubMed, Web of Science, and Scopus databases were comprehensively searched from inception to January 2023. Titles, abstracts and full text screening was performed to exclude non eligible articles. The risk of bias was assessed using the QUADAS-2 tool.ResultsAfter employing relevant MeSH and key terms, we identified a total of 5070 studies. Among them, 2540 duplicates, 1521 reviews or commentaries were found and excluded. Following title and abstract screening, the full text was analyzed, and 47 studies meeting the eligibility criteria were retained. The studies included in this systematic review comprehensively recapitulate the latest observations associating changes of the ECM composition following remodeling with the traits of the tumor immune cell infiltration. The present study provides for the first time a broad view of the tight association between ECM molecules and ICIs efficacy in different tumor types, highlighting the importance of ECM-derived proteolytic products as promising liquid biopsy-based biomarkers to predict the efficacy of ICIs.ConclusionECM remodeling has an important impact on the immune traits of different tumor types. Increasing evidence pinpoint at ECM-derived molecules as putative biomarkers to identify the patients that would most likely benefit from ICIs treatments.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42022351180, identifier CRD42022351180. |
| first_indexed | 2024-04-24T23:57:52Z |
| format | Article |
| id | doaj.art-0c21458925eb45c39a57e9940a73009f |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-24T23:57:52Z |
| publishDate | 2023-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-0c21458925eb45c39a57e9940a73009f2024-03-14T10:51:15ZengFrontiers Media S.A.Frontiers in Immunology1664-32242023-10-011410.3389/fimmu.2023.12709811270981The entanglement of extracellular matrix molecules and immune checkpoint inhibitors in cancer: a systematic review of the literatureAlbina Fejza0Greta Carobolante1Evelina Poletto2Lucrezia Camicia3Giorgia Schinello4Emanuele Di Siena5Giuseppe Ricci6Giuseppe Ricci7Maurizio Mongiat8Eva Andreuzzi9Department of Biochemistry, Faculty of Medical Sciences, UBT-Higher Education Institute, Prishtina, KosovoDepartment of Research and Diagnosis, Division of Molecular Oncology, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, Aviano, ItalyDepartment of Research and Diagnosis, Division of Molecular Oncology, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, Aviano, ItalyDepartment of Research and Diagnosis, Division of Molecular Oncology, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, Aviano, ItalyDepartment of Research and Diagnosis, Division of Molecular Oncology, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, Aviano, ItalyDepartment of Research and Diagnosis, Division of Molecular Oncology, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, Aviano, ItalyObstetrics and Gynecology, Institute for Maternal and Child Health, IRCCS Burlo Garofolo, Trieste, ItalyDepartment of Medicine, Surgery and Health Sciences, University of Trieste, Trieste, ItalyDepartment of Research and Diagnosis, Division of Molecular Oncology, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, Aviano, ItalyObstetrics and Gynecology, Institute for Maternal and Child Health, IRCCS Burlo Garofolo, Trieste, ItalyIntroductionImmune-checkpoint inhibitors (ICIs) have emerged as a core pillar of cancer therapy as single agents or in combination regimens both in adults and children. Unfortunately, ICIs provide a long-lasting therapeutic effect in only one third of the patients. Thus, the search for predictive biomarkers of responsiveness to ICIs remains an urgent clinical need. The efficacy of ICIs treatments is strongly affected not only by the specific characteristics of cancer cells and the levels of immune checkpoint ligands, but also by other components of the tumor microenvironment, among which the extracellular matrix (ECM) is emerging as key player. With the aim to comprehensively describe the relation between ECM and ICIs’ efficacy in cancer patients, the present review systematically evaluated the current literature regarding ECM remodeling in association with immunotherapeutic approaches.MethodsThis review followed the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) guidelines and was registered at the International Prospective Register of Systematic Reviews (PROSPERO, CRD42022351180). PubMed, Web of Science, and Scopus databases were comprehensively searched from inception to January 2023. Titles, abstracts and full text screening was performed to exclude non eligible articles. The risk of bias was assessed using the QUADAS-2 tool.ResultsAfter employing relevant MeSH and key terms, we identified a total of 5070 studies. Among them, 2540 duplicates, 1521 reviews or commentaries were found and excluded. Following title and abstract screening, the full text was analyzed, and 47 studies meeting the eligibility criteria were retained. The studies included in this systematic review comprehensively recapitulate the latest observations associating changes of the ECM composition following remodeling with the traits of the tumor immune cell infiltration. The present study provides for the first time a broad view of the tight association between ECM molecules and ICIs efficacy in different tumor types, highlighting the importance of ECM-derived proteolytic products as promising liquid biopsy-based biomarkers to predict the efficacy of ICIs.ConclusionECM remodeling has an important impact on the immune traits of different tumor types. Increasing evidence pinpoint at ECM-derived molecules as putative biomarkers to identify the patients that would most likely benefit from ICIs treatments.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42022351180, identifier CRD42022351180.https://www.frontiersin.org/articles/10.3389/fimmu.2023.1270981/fullextracellular matrixcancerimmune checkpoint inhibitorspediatric cancergynecological cancergastrointestinal cancer |
| spellingShingle | Albina Fejza Greta Carobolante Evelina Poletto Lucrezia Camicia Giorgia Schinello Emanuele Di Siena Giuseppe Ricci Giuseppe Ricci Maurizio Mongiat Eva Andreuzzi The entanglement of extracellular matrix molecules and immune checkpoint inhibitors in cancer: a systematic review of the literature Frontiers in Immunology extracellular matrix cancer immune checkpoint inhibitors pediatric cancer gynecological cancer gastrointestinal cancer |
| title | The entanglement of extracellular matrix molecules and immune checkpoint inhibitors in cancer: a systematic review of the literature |
| title_full | The entanglement of extracellular matrix molecules and immune checkpoint inhibitors in cancer: a systematic review of the literature |
| title_fullStr | The entanglement of extracellular matrix molecules and immune checkpoint inhibitors in cancer: a systematic review of the literature |
| title_full_unstemmed | The entanglement of extracellular matrix molecules and immune checkpoint inhibitors in cancer: a systematic review of the literature |
| title_short | The entanglement of extracellular matrix molecules and immune checkpoint inhibitors in cancer: a systematic review of the literature |
| title_sort | entanglement of extracellular matrix molecules and immune checkpoint inhibitors in cancer a systematic review of the literature |
| topic | extracellular matrix cancer immune checkpoint inhibitors pediatric cancer gynecological cancer gastrointestinal cancer |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1270981/full |
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