Mechanistic Studies of Homo- and Heterodinuclear Zinc Phosphoesterase Mimics: What Has Been Learned?
Phosphoesterases hydrolyze the phosphorus oxygen bond of phosphomono-, di- or triesters and are involved in various important biological processes. Carboxylate and/or hydroxido-bridged dizinc(II) sites are a widespread structural motif in this enzyme class. Much effort has been invested to unravel t...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2019-02-01
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| Series: | Frontiers in Chemistry |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fchem.2019.00082/full |
| _version_ | 1828353746783961088 |
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| author | Andrea Erxleben |
| author_facet | Andrea Erxleben |
| author_sort | Andrea Erxleben |
| collection | DOAJ |
| description | Phosphoesterases hydrolyze the phosphorus oxygen bond of phosphomono-, di- or triesters and are involved in various important biological processes. Carboxylate and/or hydroxido-bridged dizinc(II) sites are a widespread structural motif in this enzyme class. Much effort has been invested to unravel the mechanistic features that provide the enormous rate accelerations observed for enzymatic phosphate ester hydrolysis and much has been learned by using simple low-molecular-weight model systems for the biological dizinc(II) sites. This review summarizes the knowledge and mechanistic understanding of phosphoesterases that has been gained from biomimetic dizinc(II) complexes, showing the power as well as the limitations of model studies. |
| first_indexed | 2024-04-14T02:12:47Z |
| format | Article |
| id | doaj.art-0c218b08e9cf49eda2752fbdbbb02433 |
| institution | Directory Open Access Journal |
| issn | 2296-2646 |
| language | English |
| last_indexed | 2024-04-14T02:12:47Z |
| publishDate | 2019-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Chemistry |
| spelling | doaj.art-0c218b08e9cf49eda2752fbdbbb024332022-12-22T02:18:20ZengFrontiers Media S.A.Frontiers in Chemistry2296-26462019-02-01710.3389/fchem.2019.00082432903Mechanistic Studies of Homo- and Heterodinuclear Zinc Phosphoesterase Mimics: What Has Been Learned?Andrea ErxlebenPhosphoesterases hydrolyze the phosphorus oxygen bond of phosphomono-, di- or triesters and are involved in various important biological processes. Carboxylate and/or hydroxido-bridged dizinc(II) sites are a widespread structural motif in this enzyme class. Much effort has been invested to unravel the mechanistic features that provide the enormous rate accelerations observed for enzymatic phosphate ester hydrolysis and much has been learned by using simple low-molecular-weight model systems for the biological dizinc(II) sites. This review summarizes the knowledge and mechanistic understanding of phosphoesterases that has been gained from biomimetic dizinc(II) complexes, showing the power as well as the limitations of model studies.https://www.frontiersin.org/article/10.3389/fchem.2019.00082/fullzinchydrolysis (esters)phosphatasebiomimicrycatalysis |
| spellingShingle | Andrea Erxleben Mechanistic Studies of Homo- and Heterodinuclear Zinc Phosphoesterase Mimics: What Has Been Learned? Frontiers in Chemistry zinc hydrolysis (esters) phosphatase biomimicry catalysis |
| title | Mechanistic Studies of Homo- and Heterodinuclear Zinc Phosphoesterase Mimics: What Has Been Learned? |
| title_full | Mechanistic Studies of Homo- and Heterodinuclear Zinc Phosphoesterase Mimics: What Has Been Learned? |
| title_fullStr | Mechanistic Studies of Homo- and Heterodinuclear Zinc Phosphoesterase Mimics: What Has Been Learned? |
| title_full_unstemmed | Mechanistic Studies of Homo- and Heterodinuclear Zinc Phosphoesterase Mimics: What Has Been Learned? |
| title_short | Mechanistic Studies of Homo- and Heterodinuclear Zinc Phosphoesterase Mimics: What Has Been Learned? |
| title_sort | mechanistic studies of homo and heterodinuclear zinc phosphoesterase mimics what has been learned |
| topic | zinc hydrolysis (esters) phosphatase biomimicry catalysis |
| url | https://www.frontiersin.org/article/10.3389/fchem.2019.00082/full |
| work_keys_str_mv | AT andreaerxleben mechanisticstudiesofhomoandheterodinuclearzincphosphoesterasemimicswhathasbeenlearned |