Research Advances of m6A RNA Methylation in Non-small Cell Lung Cancer
N6-methyladenosine is one of the most prevalent mRNA modification in eukaryotes. The regulation of this pervasive mark is a dynamic and reversible process. m6A RNA methylation is catalyzed by m6A writers, removed by m6A erasers and recognized by m6A readers, thereby regulating multiple RNA processes...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | zho |
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Chinese Anti-Cancer Association; Chinese Antituberculosis Association
2020-11-01
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| Series: | Chinese Journal of Lung Cancer |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.3779/j.issn.1009-3419.2020.102.35 |
| _version_ | 1811292944118841344 |
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| author | Hongli PAN Xuebing LI Chen CHEN Yaguang FAN Qinghua ZHOU |
| author_facet | Hongli PAN Xuebing LI Chen CHEN Yaguang FAN Qinghua ZHOU |
| author_sort | Hongli PAN |
| collection | DOAJ |
| description | N6-methyladenosine is one of the most prevalent mRNA modification in eukaryotes. The regulation of this pervasive mark is a dynamic and reversible process. m6A RNA methylation is catalyzed by m6A writers, removed by m6A erasers and recognized by m6A readers, thereby regulating multiple RNA processes including alternative splicing, nuclear export, degradation and translation. Accumulated evidence suggests that m6A modification plays a crucial role in the pathogenic mechanism and malignant progression in non-small cell lung cancer (NSCLC), including cell survival, proliferation, migration, invasion, tumor metastasis and drug resistance. Moreover, the expression of m6A and its related proteins are dysregulated in clinical samples and circulating tumor cells (CTCs) of lung cancer patients, indicating that m6A modification may serve as a novel potential biomarker for the diagnosis and prognosis of lung cancer. In this review, by summarizing a great number of recent reports related to m6A’s function and its modulators, we aim to provide a new insight on the early diagnosis and drug development in NSCLC therapy. |
| first_indexed | 2024-04-13T04:53:05Z |
| format | Article |
| id | doaj.art-0c22a8c628ee4f32a9f6b5ec940e2ccd |
| institution | Directory Open Access Journal |
| issn | 1009-3419 1999-6187 |
| language | zho |
| last_indexed | 2024-04-13T04:53:05Z |
| publishDate | 2020-11-01 |
| publisher | Chinese Anti-Cancer Association; Chinese Antituberculosis Association |
| record_format | Article |
| series | Chinese Journal of Lung Cancer |
| spelling | doaj.art-0c22a8c628ee4f32a9f6b5ec940e2ccd2022-12-22T03:01:35ZzhoChinese Anti-Cancer Association; Chinese Antituberculosis AssociationChinese Journal of Lung Cancer1009-34191999-61872020-11-01231196196910.3779/j.issn.1009-3419.2020.102.35Research Advances of m6A RNA Methylation in Non-small Cell Lung CancerHongli PAN0Xuebing LI1Chen CHEN2Yaguang FAN3Qinghua ZHOU4Tianjin Key Laboratory of Lung Cancer Metastasis and Tumor Microenvironment, Tianjin Lung Cancer Institute,
Tianjin Medical University General Hospital, Tianjin 300052, ChinaTianjin Key Laboratory of Lung Cancer Metastasis and Tumor Microenvironment, Tianjin Lung Cancer Institute,
Tianjin Medical University General Hospital, Tianjin 300052, ChinaTianjin Key Laboratory of Lung Cancer Metastasis and Tumor Microenvironment, Tianjin Lung Cancer Institute,
Tianjin Medical University General Hospital, Tianjin 300052, ChinaTianjin Key Laboratory of Lung Cancer Metastasis and Tumor Microenvironment, Tianjin Lung Cancer Institute,
Tianjin Medical University General Hospital, Tianjin 300052, ChinaTianjin Key Laboratory of Lung Cancer Metastasis and Tumor Microenvironment, Tianjin Lung Cancer Institute,
Tianjin Medical University General Hospital, Tianjin 300052, ChinaN6-methyladenosine is one of the most prevalent mRNA modification in eukaryotes. The regulation of this pervasive mark is a dynamic and reversible process. m6A RNA methylation is catalyzed by m6A writers, removed by m6A erasers and recognized by m6A readers, thereby regulating multiple RNA processes including alternative splicing, nuclear export, degradation and translation. Accumulated evidence suggests that m6A modification plays a crucial role in the pathogenic mechanism and malignant progression in non-small cell lung cancer (NSCLC), including cell survival, proliferation, migration, invasion, tumor metastasis and drug resistance. Moreover, the expression of m6A and its related proteins are dysregulated in clinical samples and circulating tumor cells (CTCs) of lung cancer patients, indicating that m6A modification may serve as a novel potential biomarker for the diagnosis and prognosis of lung cancer. In this review, by summarizing a great number of recent reports related to m6A’s function and its modulators, we aim to provide a new insight on the early diagnosis and drug development in NSCLC therapy.http://dx.doi.org/10.3779/j.issn.1009-3419.2020.102.35lung neoplasmsn6-methyladenosinerna methylationepigenetic modification |
| spellingShingle | Hongli PAN Xuebing LI Chen CHEN Yaguang FAN Qinghua ZHOU Research Advances of m6A RNA Methylation in Non-small Cell Lung Cancer Chinese Journal of Lung Cancer lung neoplasms n6-methyladenosine rna methylation epigenetic modification |
| title | Research Advances of m6A RNA Methylation in Non-small Cell Lung Cancer |
| title_full | Research Advances of m6A RNA Methylation in Non-small Cell Lung Cancer |
| title_fullStr | Research Advances of m6A RNA Methylation in Non-small Cell Lung Cancer |
| title_full_unstemmed | Research Advances of m6A RNA Methylation in Non-small Cell Lung Cancer |
| title_short | Research Advances of m6A RNA Methylation in Non-small Cell Lung Cancer |
| title_sort | research advances of m6a rna methylation in non small cell lung cancer |
| topic | lung neoplasms n6-methyladenosine rna methylation epigenetic modification |
| url | http://dx.doi.org/10.3779/j.issn.1009-3419.2020.102.35 |
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