| Summary: | In studying the development of tolerance to common hospital cleaners (Oxivir<sup>®</sup> and CaviCide™) in clinical isolate stocks of the emerging, multidrug-resistant yeast pathogen <i>Candida auris</i>, we selected for a cleaner-tolerant subpopulation of a more common nosocomial pathogen, <i>Candida glabrata</i>. Through the purification of each species and subsequent competition and other analyses, we determined that <i>C. glabrata</i> is capable of readily dominating mixed populations of <i>C. auris</i> and <i>C. glabrata</i> when exposed to hospital cleaners. This result suggests that exposure to antimicrobial compounds can preferentially select for low-level, stress-tolerant fungal pathogens. These findings indicate that clinical disinfection practices could contribute to the selection of tolerant, pathogenic microbes that persist within healthcare settings.
|
|---|