HLA alleles and haplotypes in Sudanese population and their relationship with Mediterraneans
Abstract The contribution of migrated people from once green Sahara (about 10,000–6000 years bc) towards Mediterranean area had probably a double effect: both genetic and cultural connections have been described between Western Europe and North Africa. Sudanese populations from different ethnicities...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2023-09-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-023-40173-x |
| _version_ | 1797452694872391680 |
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| author | Fabio Suarez-Trujillo Sayda El-Safi Ignacio Juarez José Palacio-Gruber Alejandro Sanchez-Orta José Manuel Martin-Villa Antonio Arnaiz-Villena |
| author_facet | Fabio Suarez-Trujillo Sayda El-Safi Ignacio Juarez José Palacio-Gruber Alejandro Sanchez-Orta José Manuel Martin-Villa Antonio Arnaiz-Villena |
| author_sort | Fabio Suarez-Trujillo |
| collection | DOAJ |
| description | Abstract The contribution of migrated people from once green Sahara (about 10,000–6000 years bc) towards Mediterranean area had probably a double effect: both genetic and cultural connections have been described between Western Europe and North Africa. Sudanese populations from different ethnicities have been studied for HLA-A, -B, -DRB1 and -DQB1 antigens by a standard microlymphotoxicity method. Results found show that Nubians are genetically related with African Sub-Saharan populations and distant from other Sudanese tribes, who are closer to Mediterranean populations than to Sub-Saharan ones. This is concordant with other authors and meta-analysis data. Our present work is, to our knowledge, the first and only one HLA research that studies Sudanese people according to different Sudan ethnic groups: samples were collected before Sudan partition between North and South. A prehistoric genetic and peoples exchange between Africa and the Mediterranean basin may be observed and is supported with the results obtained in this Sudanese HLA study. However, demic diffusion model of agriculture and other anthropological traits from Middle East to West Europe/Maghreb do not exist: a more detailed Sahel and North African countries ancient and recent admixture studies are also being carried out which may clearer explain pastoralists/agriculture innovations origins in Eurafrican Mediterranean and Atlantic façade. |
| first_indexed | 2024-03-09T15:12:22Z |
| format | Article |
| id | doaj.art-0c26edabb7e14370b360fb28ac951d75 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-03-09T15:12:22Z |
| publishDate | 2023-09-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-0c26edabb7e14370b360fb28ac951d752023-11-26T13:17:03ZengNature PortfolioScientific Reports2045-23222023-09-0113111110.1038/s41598-023-40173-xHLA alleles and haplotypes in Sudanese population and their relationship with MediterraneansFabio Suarez-Trujillo0Sayda El-Safi1Ignacio Juarez2José Palacio-Gruber3Alejandro Sanchez-Orta4José Manuel Martin-Villa5Antonio Arnaiz-Villena6Department of Immunology, School of Medicine, University ComplutenseIbn Sina Specialized HospitalDepartment of Immunology, School of Medicine, University ComplutenseDepartment of Immunology, School of Medicine, University ComplutenseDepartment of Immunology, School of Medicine, University ComplutenseDepartment of Immunology, School of Medicine, University ComplutenseDepartment of Immunology, School of Medicine, University ComplutenseAbstract The contribution of migrated people from once green Sahara (about 10,000–6000 years bc) towards Mediterranean area had probably a double effect: both genetic and cultural connections have been described between Western Europe and North Africa. Sudanese populations from different ethnicities have been studied for HLA-A, -B, -DRB1 and -DQB1 antigens by a standard microlymphotoxicity method. Results found show that Nubians are genetically related with African Sub-Saharan populations and distant from other Sudanese tribes, who are closer to Mediterranean populations than to Sub-Saharan ones. This is concordant with other authors and meta-analysis data. Our present work is, to our knowledge, the first and only one HLA research that studies Sudanese people according to different Sudan ethnic groups: samples were collected before Sudan partition between North and South. A prehistoric genetic and peoples exchange between Africa and the Mediterranean basin may be observed and is supported with the results obtained in this Sudanese HLA study. However, demic diffusion model of agriculture and other anthropological traits from Middle East to West Europe/Maghreb do not exist: a more detailed Sahel and North African countries ancient and recent admixture studies are also being carried out which may clearer explain pastoralists/agriculture innovations origins in Eurafrican Mediterranean and Atlantic façade.https://doi.org/10.1038/s41598-023-40173-x |
| spellingShingle | Fabio Suarez-Trujillo Sayda El-Safi Ignacio Juarez José Palacio-Gruber Alejandro Sanchez-Orta José Manuel Martin-Villa Antonio Arnaiz-Villena HLA alleles and haplotypes in Sudanese population and their relationship with Mediterraneans Scientific Reports |
| title | HLA alleles and haplotypes in Sudanese population and their relationship with Mediterraneans |
| title_full | HLA alleles and haplotypes in Sudanese population and their relationship with Mediterraneans |
| title_fullStr | HLA alleles and haplotypes in Sudanese population and their relationship with Mediterraneans |
| title_full_unstemmed | HLA alleles and haplotypes in Sudanese population and their relationship with Mediterraneans |
| title_short | HLA alleles and haplotypes in Sudanese population and their relationship with Mediterraneans |
| title_sort | hla alleles and haplotypes in sudanese population and their relationship with mediterraneans |
| url | https://doi.org/10.1038/s41598-023-40173-x |
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