Polyfunctional type-1, -2, and -17 CD8⁺ T cell responses to apoptotic self-antigens correlate with the chronic evolution of hepatitis C virus infection.
Caspase-dependent cleavage of antigens associated with apoptotic cells plays a prominent role in the generation of CD8⁺ T cell responses in various infectious diseases. We found that the emergence of a large population of autoreactive CD8⁺ T effector cells specific for apoptotic T cell-associated se...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2012-01-01
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| Series: | PLoS Pathogens |
| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22737070/?tool=EBI |
| _version_ | 1828902867694518272 |
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| author | Debora Franceschini Paola Del Porto Silvia Piconese Emanuele Trella Daniele Accapezzato Marino Paroli Stefania Morrone Enza Piccolella Enea Spada Alfonso Mele John Sidney Alessandro Sette Vincenzo Barnaba |
| author_facet | Debora Franceschini Paola Del Porto Silvia Piconese Emanuele Trella Daniele Accapezzato Marino Paroli Stefania Morrone Enza Piccolella Enea Spada Alfonso Mele John Sidney Alessandro Sette Vincenzo Barnaba |
| author_sort | Debora Franceschini |
| collection | DOAJ |
| description | Caspase-dependent cleavage of antigens associated with apoptotic cells plays a prominent role in the generation of CD8⁺ T cell responses in various infectious diseases. We found that the emergence of a large population of autoreactive CD8⁺ T effector cells specific for apoptotic T cell-associated self-epitopes exceeds the antiviral responses in patients with acute hepatitis C virus infection. Importantly, they endow mixed polyfunctional type-1, type-2 and type-17 responses and correlate with the chronic progression of infection. This evolution is related to the selection of autoreactive CD8⁺ T cells with higher T cell receptor avidity, whereas those with lower avidity undergo prompt contraction in patients who clear infection. These findings demonstrate a previously undescribed strict link between the emergence of high frequencies of mixed autoreactive CD8⁺ T cells producing a broad array of cytokines (IFN-γ, IL-17, IL-4, IL-2…) and the progression toward chronic disease in a human model of acute infection. |
| first_indexed | 2024-12-13T16:24:25Z |
| format | Article |
| id | doaj.art-0c284bd30e0947159205b72baa32064d |
| institution | Directory Open Access Journal |
| issn | 1553-7366 1553-7374 |
| language | English |
| last_indexed | 2024-12-13T16:24:25Z |
| publishDate | 2012-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Pathogens |
| spelling | doaj.art-0c284bd30e0947159205b72baa32064d2022-12-21T23:38:38ZengPublic Library of Science (PLoS)PLoS Pathogens1553-73661553-73742012-01-0186e100275910.1371/journal.ppat.1002759Polyfunctional type-1, -2, and -17 CD8⁺ T cell responses to apoptotic self-antigens correlate with the chronic evolution of hepatitis C virus infection.Debora FranceschiniPaola Del PortoSilvia PiconeseEmanuele TrellaDaniele AccapezzatoMarino ParoliStefania MorroneEnza PiccolellaEnea SpadaAlfonso MeleJohn SidneyAlessandro SetteVincenzo BarnabaCaspase-dependent cleavage of antigens associated with apoptotic cells plays a prominent role in the generation of CD8⁺ T cell responses in various infectious diseases. We found that the emergence of a large population of autoreactive CD8⁺ T effector cells specific for apoptotic T cell-associated self-epitopes exceeds the antiviral responses in patients with acute hepatitis C virus infection. Importantly, they endow mixed polyfunctional type-1, type-2 and type-17 responses and correlate with the chronic progression of infection. This evolution is related to the selection of autoreactive CD8⁺ T cells with higher T cell receptor avidity, whereas those with lower avidity undergo prompt contraction in patients who clear infection. These findings demonstrate a previously undescribed strict link between the emergence of high frequencies of mixed autoreactive CD8⁺ T cells producing a broad array of cytokines (IFN-γ, IL-17, IL-4, IL-2…) and the progression toward chronic disease in a human model of acute infection.https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22737070/?tool=EBI |
| spellingShingle | Debora Franceschini Paola Del Porto Silvia Piconese Emanuele Trella Daniele Accapezzato Marino Paroli Stefania Morrone Enza Piccolella Enea Spada Alfonso Mele John Sidney Alessandro Sette Vincenzo Barnaba Polyfunctional type-1, -2, and -17 CD8⁺ T cell responses to apoptotic self-antigens correlate with the chronic evolution of hepatitis C virus infection. PLoS Pathogens |
| title | Polyfunctional type-1, -2, and -17 CD8⁺ T cell responses to apoptotic self-antigens correlate with the chronic evolution of hepatitis C virus infection. |
| title_full | Polyfunctional type-1, -2, and -17 CD8⁺ T cell responses to apoptotic self-antigens correlate with the chronic evolution of hepatitis C virus infection. |
| title_fullStr | Polyfunctional type-1, -2, and -17 CD8⁺ T cell responses to apoptotic self-antigens correlate with the chronic evolution of hepatitis C virus infection. |
| title_full_unstemmed | Polyfunctional type-1, -2, and -17 CD8⁺ T cell responses to apoptotic self-antigens correlate with the chronic evolution of hepatitis C virus infection. |
| title_short | Polyfunctional type-1, -2, and -17 CD8⁺ T cell responses to apoptotic self-antigens correlate with the chronic evolution of hepatitis C virus infection. |
| title_sort | polyfunctional type 1 2 and 17 cd8⁺ t cell responses to apoptotic self antigens correlate with the chronic evolution of hepatitis c virus infection |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22737070/?tool=EBI |
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