Polyfunctional type-1, -2, and -17 CD8⁺ T cell responses to apoptotic self-antigens correlate with the chronic evolution of hepatitis C virus infection.

Polyfunctional type-1, -2, and -17 CD8⁺ T cell responses to apoptotic self-antigens correlate with the chronic evolution of hepatitis C virus infection.

Caspase-dependent cleavage of antigens associated with apoptotic cells plays a prominent role in the generation of CD8⁺ T cell responses in various infectious diseases. We found that the emergence of a large population of autoreactive CD8⁺ T effector cells specific for apoptotic T cell-associated se...

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Main Authors: Debora Franceschini, Paola Del Porto, Silvia Piconese, Emanuele Trella, Daniele Accapezzato, Marino Paroli, Stefania Morrone, Enza Piccolella, Enea Spada, Alfonso Mele, John Sidney, Alessandro Sette, Vincenzo Barnaba
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS Pathogens
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22737070/?tool=EBI

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