Dyslipidemia as Predictor of Missed Miscarriage
Background: This study aimed at finding the diagnostic and prognostic possibilities of determining apoC-II, as a serological marker for MM in early gestation. Methods and Results: The study included 182 pregnant women aged between 18 and 45 years at gestational age under 11 weeks. All women were d...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
International Medical Research and Development Corporation
2021-12-01
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| Series: | International Journal of Biomedicine |
| Subjects: | |
| Online Access: | http://ijbm.org/articles/i44/ijbm_11(4)_oa4.pdf |
| Summary: | Background: This study aimed at finding the diagnostic and prognostic possibilities of determining apoC-II, as a serological marker for MM in early gestation.
Methods and Results: The study included 182 pregnant women aged between 18 and 45 years at gestational age under 11 weeks. All women were divided into 3 groups. Group 1 (Gr1) included 90 women with MM; Group 2 (Gr2) included 52 women with spontaneous miscarriage; Group 3 included 40 women without pathology (control group [CG]). Lipid metabolism disorders were diagnosed according to the Russian national recommendations of the VII revision(the Russian Society of Cardiologists [RSC, 2020]), considering the European recommendations (2019). Proteomic analysis of the blood serum was performed using LC-MS. Abnormalities in the lipid profile were more common in patients with MM and spontaneous abortions: 62.2% and 59.7% of cases, respectively, which correlates with the identified marker apoC-II in Gr1 and Gr2.
Conclusion: ApoC-II can be considered as the most promising serologic marker for MM in the early gestation period for women with dyslipidemia. |
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| ISSN: | 2158-0510 2158-0529 |