Dyslipidemia as Predictor of Missed Miscarriage
Background: This study aimed at finding the diagnostic and prognostic possibilities of determining apoC-II, as a serological marker for MM in early gestation. Methods and Results: The study included 182 pregnant women aged between 18 and 45 years at gestational age under 11 weeks. All women were d...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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International Medical Research and Development Corporation
2021-12-01
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| Series: | International Journal of Biomedicine |
| Subjects: | |
| Online Access: | http://ijbm.org/articles/i44/ijbm_11(4)_oa4.pdf |
| _version_ | 1819101579746213888 |
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| author | Agamurad A. Orazmuradov Sergey G. Morozov Anastasiya N. Akhmatova Khalid Haddad Alexander M. Lopatin Fatima U. Ramazanova1 Irina V. Bekbaeva Sergey I. Kyrtikov Zhasmina Z. Suleymanova Aleksey A. Lukaev |
| author_facet | Agamurad A. Orazmuradov Sergey G. Morozov Anastasiya N. Akhmatova Khalid Haddad Alexander M. Lopatin Fatima U. Ramazanova1 Irina V. Bekbaeva Sergey I. Kyrtikov Zhasmina Z. Suleymanova Aleksey A. Lukaev |
| author_sort | Agamurad A. Orazmuradov |
| collection | DOAJ |
| description | Background: This study aimed at finding the diagnostic and prognostic possibilities of determining apoC-II, as a serological marker for MM in early gestation.
Methods and Results: The study included 182 pregnant women aged between 18 and 45 years at gestational age under 11 weeks. All women were divided into 3 groups. Group 1 (Gr1) included 90 women with MM; Group 2 (Gr2) included 52 women with spontaneous miscarriage; Group 3 included 40 women without pathology (control group [CG]). Lipid metabolism disorders were diagnosed according to the Russian national recommendations of the VII revision(the Russian Society of Cardiologists [RSC, 2020]), considering the European recommendations (2019). Proteomic analysis of the blood serum was performed using LC-MS. Abnormalities in the lipid profile were more common in patients with MM and spontaneous abortions: 62.2% and 59.7% of cases, respectively, which correlates with the identified marker apoC-II in Gr1 and Gr2.
Conclusion: ApoC-II can be considered as the most promising serologic marker for MM in the early gestation period for women with dyslipidemia. |
| first_indexed | 2024-12-22T01:20:55Z |
| format | Article |
| id | doaj.art-0c2917c8e47841bcadc83bcc520063fe |
| institution | Directory Open Access Journal |
| issn | 2158-0510 2158-0529 |
| language | English |
| last_indexed | 2024-12-22T01:20:55Z |
| publishDate | 2021-12-01 |
| publisher | International Medical Research and Development Corporation |
| record_format | Article |
| series | International Journal of Biomedicine |
| spelling | doaj.art-0c2917c8e47841bcadc83bcc520063fe2022-12-21T18:43:43ZengInternational Medical Research and Development CorporationInternational Journal of Biomedicine2158-05102158-05292021-12-0111441842110.21103/Article11(4)_OA4Dyslipidemia as Predictor of Missed MiscarriageAgamurad A. Orazmuradov0Sergey G. Morozov 1Anastasiya N. Akhmatova2Khalid Haddad3Alexander M. Lopatin4Fatima U. Ramazanova15Irina V. Bekbaeva6Sergey I. Kyrtikov7Zhasmina Z. Suleymanova8Aleksey A. Lukaev9Peoples’ Friendship University of Russia (RUDN University), Moscow, RussiaThe Institute of General Pathology and Pathophysiology, Moscow, RussiaPeoples’ Friendship University of Russia (RUDN University), Moscow, RussiaPeoples’ Friendship University of Russia (RUDN University), Moscow, RussiaPeoples’ Friendship University of Russia (RUDN University), Moscow, RussiaPeoples’ Friendship University of Russia (RUDN University), Moscow, RussiaPeoples’ Friendship University of Russia (RUDN University), Moscow, RussiaPeoples’ Friendship University of Russia (RUDN University), Moscow, RussiaPeoples’ Friendship University of Russia (RUDN University), Moscow, RussiaMytishchi City Clinical Hospital Mytishchi, Moscow Region, RussiaBackground: This study aimed at finding the diagnostic and prognostic possibilities of determining apoC-II, as a serological marker for MM in early gestation. Methods and Results: The study included 182 pregnant women aged between 18 and 45 years at gestational age under 11 weeks. All women were divided into 3 groups. Group 1 (Gr1) included 90 women with MM; Group 2 (Gr2) included 52 women with spontaneous miscarriage; Group 3 included 40 women without pathology (control group [CG]). Lipid metabolism disorders were diagnosed according to the Russian national recommendations of the VII revision(the Russian Society of Cardiologists [RSC, 2020]), considering the European recommendations (2019). Proteomic analysis of the blood serum was performed using LC-MS. Abnormalities in the lipid profile were more common in patients with MM and spontaneous abortions: 62.2% and 59.7% of cases, respectively, which correlates with the identified marker apoC-II in Gr1 and Gr2. Conclusion: ApoC-II can be considered as the most promising serologic marker for MM in the early gestation period for women with dyslipidemia.http://ijbm.org/articles/i44/ijbm_11(4)_oa4.pdfmissed miscarriagedyslipidemiaapolipoprotein c-iiserological markers |
| spellingShingle | Agamurad A. Orazmuradov Sergey G. Morozov Anastasiya N. Akhmatova Khalid Haddad Alexander M. Lopatin Fatima U. Ramazanova1 Irina V. Bekbaeva Sergey I. Kyrtikov Zhasmina Z. Suleymanova Aleksey A. Lukaev Dyslipidemia as Predictor of Missed Miscarriage International Journal of Biomedicine missed miscarriage dyslipidemia apolipoprotein c-ii serological markers |
| title | Dyslipidemia as Predictor of Missed Miscarriage |
| title_full | Dyslipidemia as Predictor of Missed Miscarriage |
| title_fullStr | Dyslipidemia as Predictor of Missed Miscarriage |
| title_full_unstemmed | Dyslipidemia as Predictor of Missed Miscarriage |
| title_short | Dyslipidemia as Predictor of Missed Miscarriage |
| title_sort | dyslipidemia as predictor of missed miscarriage |
| topic | missed miscarriage dyslipidemia apolipoprotein c-ii serological markers |
| url | http://ijbm.org/articles/i44/ijbm_11(4)_oa4.pdf |
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