Valence-encoding in the lateral habenula arises from the entopeduncular region
Lateral habenula (LHb) neurons are activated by negative motivational stimuli and play key roles in the pathophysiology of depression. Prior reports suggested that rostral entopeduncular nucleus (rEPN) neurons drive these responses in the LHb and rostromedial tegmental nucleus (RMTg), but these infl...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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eLife Sciences Publications Ltd
2019-03-01
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| Series: | eLife |
| Subjects: | |
| Online Access: | https://elifesciences.org/articles/41223 |
| _version_ | 1811202678813884416 |
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| author | Hao Li Dominika Pullmann Thomas C Jhou |
| author_facet | Hao Li Dominika Pullmann Thomas C Jhou |
| author_sort | Hao Li |
| collection | DOAJ |
| description | Lateral habenula (LHb) neurons are activated by negative motivational stimuli and play key roles in the pathophysiology of depression. Prior reports suggested that rostral entopeduncular nucleus (rEPN) neurons drive these responses in the LHb and rostromedial tegmental nucleus (RMTg), but these influences remain untested. Using rabies viral tracers, we demonstrate disynaptic projections from the rEPN to RMTg, but not VTA, via the LHb in rats. Using in vivo electrophysiology, we find that rEPN or LHb subpopulations exhibit activation/inhibition patterns after negative/positive motivational stimuli, similar to the RMTg, while temporary inactivation of a region centered on the rEPN decreases LHb basal and burst firing, and reduces valence-related signals in LHb neurons. Additionally, excitotoxic rEPN lesions partly diminish footshock-induced cFos in the LHb and RMTg. Together, our findings indicate an important role of the rEPN, and possibly immediately adjacent hypothalamus, in driving basal activities and valence processing in LHb and RMTg neurons. |
| first_indexed | 2024-04-12T02:43:49Z |
| format | Article |
| id | doaj.art-0c2a4cf7117c405a88f9550f72c5c4bc |
| institution | Directory Open Access Journal |
| issn | 2050-084X |
| language | English |
| last_indexed | 2024-04-12T02:43:49Z |
| publishDate | 2019-03-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj.art-0c2a4cf7117c405a88f9550f72c5c4bc2022-12-22T03:51:15ZengeLife Sciences Publications LtdeLife2050-084X2019-03-01810.7554/eLife.41223Valence-encoding in the lateral habenula arises from the entopeduncular regionHao Li0Dominika Pullmann1Thomas C Jhou2https://orcid.org/0000-0001-8811-0156Department of Neuroscience, Medical University of South Carolina, Charleston, United StatesDepartment of Neuroscience, Medical University of South Carolina, Charleston, United StatesDepartment of Neuroscience, Medical University of South Carolina, Charleston, United StatesLateral habenula (LHb) neurons are activated by negative motivational stimuli and play key roles in the pathophysiology of depression. Prior reports suggested that rostral entopeduncular nucleus (rEPN) neurons drive these responses in the LHb and rostromedial tegmental nucleus (RMTg), but these influences remain untested. Using rabies viral tracers, we demonstrate disynaptic projections from the rEPN to RMTg, but not VTA, via the LHb in rats. Using in vivo electrophysiology, we find that rEPN or LHb subpopulations exhibit activation/inhibition patterns after negative/positive motivational stimuli, similar to the RMTg, while temporary inactivation of a region centered on the rEPN decreases LHb basal and burst firing, and reduces valence-related signals in LHb neurons. Additionally, excitotoxic rEPN lesions partly diminish footshock-induced cFos in the LHb and RMTg. Together, our findings indicate an important role of the rEPN, and possibly immediately adjacent hypothalamus, in driving basal activities and valence processing in LHb and RMTg neurons.https://elifesciences.org/articles/41223habenulaentopeduncularaversivermtgvalenceVTA |
| spellingShingle | Hao Li Dominika Pullmann Thomas C Jhou Valence-encoding in the lateral habenula arises from the entopeduncular region eLife habenula entopeduncular aversive rmtg valence VTA |
| title | Valence-encoding in the lateral habenula arises from the entopeduncular region |
| title_full | Valence-encoding in the lateral habenula arises from the entopeduncular region |
| title_fullStr | Valence-encoding in the lateral habenula arises from the entopeduncular region |
| title_full_unstemmed | Valence-encoding in the lateral habenula arises from the entopeduncular region |
| title_short | Valence-encoding in the lateral habenula arises from the entopeduncular region |
| title_sort | valence encoding in the lateral habenula arises from the entopeduncular region |
| topic | habenula entopeduncular aversive rmtg valence VTA |
| url | https://elifesciences.org/articles/41223 |
| work_keys_str_mv | AT haoli valenceencodinginthelateralhabenulaarisesfromtheentopeduncularregion AT dominikapullmann valenceencodinginthelateralhabenulaarisesfromtheentopeduncularregion AT thomascjhou valenceencodinginthelateralhabenulaarisesfromtheentopeduncularregion |